Abstract：
:Longitudinal organ bath preparations of the rat duodenum, jejunum and ileum were tested for their responsiveness to GABA-receptor agonists. The GABAA-receptor agonists, GABA and 3APS, induced non-adrenergic, non-cholinergic relaxations and/or contractions, although the magnitude and type of response varied depending upon the region tested. All regions relaxed to applied GABA or 3APS, however the jejunum and ileum also responded with cholinergic contractions. These relaxant and contractile actions were neurogenic and sensitive to blockade by the GABA antagonists bicuculline or picrotoxinin, and desensitization to either agonist. The GABAB-receptor agonist baclofen, caused a reduction in electrically evoked cholinergic contractions. These inhibitory actions of baclofen were insensitive to bicuculline or picrotoxinin. Taken together, these results show that GABA-ergic actions in the rat small intestine are mediated by two pharmacologically distinct neural receptor populations, the GABAA and GABAB sites, the distribution and sensitivity of which differ along the length of the small intestine.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Krantis A,Harding RKdoi
10.1016/0014-2999(87)90274-3subject
Has Abstractpub_date
1987-09-11 00:00:00pages
291-8issue
2eissn
0014-2999issn
1879-0712pii
0014-2999(87)90274-3journal_volume
141pub_type
杂志文章abstract：:Agonists of adenosine A1 receptors have been frequently proposed as candidates for clinical development in treatment of cerebral ischemia and stroke. Numerous experimental studies have shown that pre- and postischemic administration of these drugs results in a very significant reduction of postischemic brain damage. H...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(96)00101-x
更新日期：1996-04-29 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1982-05-07 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(88)90670-x
更新日期：1988-05-10 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1990-09-04 00:00:00
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：2004-01-19 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1981-04-24 00:00:00
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更新日期：1992-05-01 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1984-08-03 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1992-11-03 00:00:00
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journal_title：European journal of pharmacology
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更新日期：2019-02-05 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(87)90285-8
更新日期：1987-08-21 00:00:00
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1989-10-10 00:00:00
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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更新日期：1987-08-21 00:00:00
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(93)90163-c
更新日期：1993-10-12 00:00:00
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journal_title：European journal of pharmacology
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更新日期：2019-11-05 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2015.04.009
更新日期：2015-08-05 00:00:00
