Effects of guinea pig neurotensin ([Ser7]neurotensin) on gastrointestinal smooth muscle.

abstract：:The putative imidazoline I(3) receptor antagonist 2-(2-ethyl-2,3-dihydrobenzo[b]furan-2-yl)-1H-imidazole (KU14R) has been shown to block the effects of the atypical I(3) agonist efaroxan at the level of the ATP-sensitive K(+) (K(ATP)) channel in isolated pancreatic islet beta cells, but its effects in vivo are not kno...

journal_title：European journal of pharmacology

authors： Mayer G,Taberner PV

更新日期：2002-11-01 00:00:00

abstract：:Fibrate derivatives are commonly used to treat hyperlipidaemia; however, the mechanism of the antilipidaemic action of these drugs is still unknown. The effect of clofibrate (fibrate derivative) administration for 14 days on lipogenesis and on malic enzyme (EC 1.1.1.40) and fatty acid synthase (EC 2.3.1.85) gene expre...

journal_title：European journal of pharmacology

authors： Karbowska J,Kochan Z,Zelewski L,Swierczynski J

更新日期：1999-04-16 00:00:00

abstract：:This study investigates the anti-inflammatory effects of 1-(2-chlorophenyl)-N-methyl-N(1-methylpropyl)-3-isoquinoline carboxamide and 7-chloro-5-(4-chlorophenyl)-1, 3-dihydro-1-methyl-2-H-1,4-benzodiazepin-2-one in paw oedema induced by carrageenan in mice. Pretreatment (24 h) with both ligands inhibited oedema format...

journal_title：European journal of pharmacology

authors： Torres SR,Nardi GM,Ferrara P,Ribeiro-do-Valle RM,Farges RC

更新日期：1999-12-03 00:00:00

abstract：:Morphine and aspartic acid were administered separately and in combination to 80 rats divided into 8 groups. Ten and 20 min following the injections, brain, liver and kidney L-asparaginase activity was determined. Morphine decreased brain and liver L-asparaginase activity and increased that of kidney. Aspartic acid co...

journal_title：European journal of pharmacology

authors： Koyuncuoğlu H,Keyer-Uysal M,Berkman K,Güngör M,Genç EM

更新日期：1979-12-20 00:00:00

abstract：:Intravenous amiodarone (Amiodarone i.v.) is widely used to treat cardiac arrhythmias. The most frequent clinical adverse event associated with Amiodarone i.v. administration is systemic hypotension which has been attributed to the cosolvents used in the formulation, polysorbate 80 and benzyl alcohol. To minimize hypot...

journal_title：European journal of pharmacology

authors： Cushing DJ,Kowey PR,Cooper WD,Massey BW,Gralinski MR,Lipicky RJ

更新日期：2009-04-01 00:00:00

abstract：:G-protein coupled receptors (GPCRs) share a common seven-transmembrane topology and mediate cellular responses to a variety of extracellular signals. However, structural and functional approaches to GPCRs have often been limited by the difficulty of producing a sufficient amount of receptor protein using conventional ...

journal_title：European journal of pharmacology

authors： Arimitsu E,Ogasawara T,Takeda H,Sawasaki T,Ikeda Y,Hiasa Y,Maeyama K

更新日期：2014-12-15 00:00:00

abstract：:The new platinum (II) and palladium (II) complexes (2-4) with ligands 5-(2-hydroxyphenyl)-1,3-dimethyl-4-(dimethoxy)phosphonyl-1H]-pyrazole (1a) and 5-(2-hydroxyphenyl)-1,3-dimethyl-4-methoxycarbonyl-1H]-2-pyrazole (1b) were screened in a search for novel anticancer agents. Thus, alkylating activity, cytotoxicity, abi...

journal_title：European journal of pharmacology

authors： Budzisz E,Krajewska U,Rozalski M,Szulawska A,Czyz M,Nawrot B

更新日期：2004-10-11 00:00:00

abstract：:The goal of these investigations was to study the role of tachykinin NK2 receptors in neonatal spinal cords using the selective NK2 receptor agonist [beta-Ala8]neurokinin A-(4-10) and the new NK2 receptor antagonist GR 94800. Experiments were performed with superfused hemisected rat and gerbil spinal cords. Dorsal roo...

journal_title：European journal of pharmacology

authors： Lepre M,Olpe HR,Evans RH,Brugger F

更新日期：1994-06-02 00:00:00

abstract：:Histamine, 4-methylhistamine and dimaprit induced a dose-dependent increase in the cyclic AMP content of chopped canine parotid gland in the presence of 3-isobutyl-1-methylxanthine. Metiamide, but not mepyramine, inhibited the effect of these agonists dose-dependently. The cyclic AMP content was also increased by 2-(2...

journal_title：European journal of pharmacology

authors： Nishibori M

更新日期：1981-12-17 00:00:00

abstract：:Only in the last few years has non-alcoholic steatohepatitis been recognized as an important and relatively common liver disease. To date, the therapeutic options are limited, vitamin E and metformin have been proposed for the treatment of this condition, although their mechanisms are not completely clarified as yet. ...

journal_title：European journal of pharmacology

authors： Raso GM,Esposito E,Iacono A,Pacilio M,Cuzzocrea S,Canani RB,Calignano A,Meli R

更新日期：2009-02-14 00:00:00

abstract：:The autoradiographic distribution of putative brain adrenomedullin receptors was investigated using [125I]human adrenomedullin(13-52) as a new radioligand. Specific [125I]human adrenomedullin(13-52) binding sites were very discretely distributed in the rat brain with enrichment seen in the choroid plexus and linings o...

journal_title：European journal of pharmacology

authors： Juaneda C,Dumont Y,Chabot JG,Quirion R

更新日期：2001-06-08 00:00:00

abstract：:This study investigates the relationship between the rate of phorbol ester-induced contraction of intact rat aorta and protein kinase C activation, as assessed by the translocation of protein kinase C from the cytosolic to the particulate fraction. Aorta was exposed to Ca(2+)-free physiologic salt solution prior to ph...

journal_title：European journal of pharmacology

authors： Bazan E,Campbell AK,Rapoport RM

更新日期：1995-08-15 00:00:00

abstract：:Geniposide (GE) can effectively inhibit diabetic nephropathy (DN), but its mechanism is unclear. The objective of this study was to explore the antidiabetic nephropathy effects of GE both in high fat diet/streptozotocin-induced DN mice and in high glucose-induced podocyte model. Renal function in DN mice was evaluated...

journal_title：European journal of pharmacology

authors： Li F,Chen Y,Li Y,Huang M,Zhao W

更新日期：2020-11-05 00:00:00

abstract：:Barbiturates derived by minor structural changes to the butenyl sidechain of the convulsant 5-ethyl-5-(3'-methyl-but-2'-enyl)-barbituric acid are almost devoid of convulsant activity, but all have anaesthetic and anticonvulsant effects. Anticonvulsant activity is also observed in the convulsant barbiturate. Increased ...

journal_title：European journal of pharmacology

authors： Andrews PR,Jones GP,Lodge D

更新日期：1979-04-15 00:00:00

abstract：:The cell adhesion molecules N-, VE- and OB-cadherin have been implicated as regulators of tumor growth and metastasis. We discuss evidence that N- and VE-cadherin play a key role in promoting blood vessel formation and stability, processes which are essential for tumor growth. Secondly, we describe the potential invol...

journal_title：European journal of pharmacology

authors： Blaschuk OW,Devemy E

更新日期：2009-12-25 00:00:00

abstract：:Persistent hyperglycemia increases a systemic oxidative stress, causing the onset of vascular endothelial dysfunction and atherosclerosis. Diallyl trisulfide (DAT), a natural organosulfur compound in garlic, has been reported to have actions of dilating blood vessels and antibacteria, etc. In this study, models of obe...

journal_title：European journal of pharmacology

authors： Liu LL,Yan L,Chen YH,Zeng GH,Zhou Y,Chen HP,Peng WJ,He M,Huang QR

更新日期：2014-02-15 00:00:00

abstract：:Nitric oxide (NO) is continuously produced in the lung and can be measured in exhaled gas of different species. To investigate a possible neuro-humoral regulation of pulmonary NO production in vivo we injected veratrine, an activator of Na(+) channels known to activate the sympathoadrenal system, in anaesthetized, mec...

journal_title：European journal of pharmacology

authors： Adding LC,Agvald P,Artlich A,Gustafsson LE

更新日期：2001-01-12 00:00:00

abstract：:The regulation of acetylcholine (ACh) lifetime by acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BuChE, EC 3.1.1.8) was evaluated in vitro in canine tracheal smooth muscle preparations. Selective inhibition of AChE by low concentrations of 1,5-bis(N-allyl-N,N-dimethyl-4-ammoniumphenyl)-pentane-3-on...

journal_title：European journal of pharmacology

authors： Adler M,Reutter SA,Moore DH,Filbert MG

更新日期：1991-11-19 00:00:00

abstract：:Subcutaneous injection of xylazine (0.1-3.0 mg/kg) produced a dose-dependent delay of small intestinal transit without affecting gastric emptying in the conscious mice. The xylazine-induced delay of small intestinal transit was antagonized by alpha 2-adrenoceptor antagonists, e.g., yohimbine, piperoxan and tolazoline....

journal_title：European journal of pharmacology

authors： Hsu WH

更新日期：1982-09-10 00:00:00

abstract：:Neither the chronic administration (40 daily subcutaneous injections) of nicotine (0.4 mg/kg) nor its withdrawal (3 days) influenced avoidance of the more aversive open runways of an elevated X-maze in rats which had been habituated to the apparatus. Lesions of the serotonergic fibres innervating the hippocampus incre...

journal_title：European journal of pharmacology

authors： Vale AL,Balfour DJ

更新日期：1987-09-11 00:00:00

abstract：:The paraventricular nucleus of the hypothalamus (PVN) contains dense orexin 2 (OX2) receptor. We examined the mechanisms of OX2 receptor-mediated excitation on electrophysiologically identified type I (putative magnocellular), low-threshold spikes (LTS)-expressing type II (putative preautonomic), and non-LTS type II (...

journal_title：European journal of pharmacology

authors： Dai YE,Lee YH,Li TL,Hwang LL

更新日期：2020-02-15 00:00:00

abstract：:Depression is very common in asthmatic patients and may increases risk for morbidity and mortality. The present work aimed to investigate the protective effect of fluoxetine, on behavioral and biochemical changes, associated with ovalbumin (OVA) - induced bronchial asthma and depression in rats. Rats were sensitized w...

journal_title：European journal of pharmacology

authors： Sherkawy MM,Abo-Youssef AM,Salama AAA,Ismaiel IE

更新日期：2018-10-15 00:00:00

abstract：:In rat carotid arteries isolated 2 weeks after balloon denudation, a significant neointima developed with little change in medial size. Associated with this neointimal hyperplasia was a marked decrease in contraction to various agents including angiotensins I and II, big endothelin-1, endothelin-1, norepinephrine, phe...

journal_title：European journal of pharmacology

authors： Antonaccio MJ,Normandin D,Ferrer P

更新日期：1994-04-11 00:00:00

abstract：:A direct comparison of the role of leukotrienes in mediating the increase in microvascular permeability associated with guinea pig tracheal and cutaneous anaphylaxis was obtained by simultaneous administration of inflammatory stimuli to both trachea and ear. The SRS-A antagonist, FPL 55712, reduced the increase in tra...

journal_title：European journal of pharmacology

authors： Woodward DF,Wasserman MA,Weichman BM

更新日期：1983-09-16 00:00:00

abstract：:Major depression is a highly prevalent disorder and is predicted to be the second leading cause of disease burden by 2020. Although many antidepressant drugs are currently available, they are far from optimal. Approximately 50% of patients do not respond to initial first line antidepressant treatment, while approximat...

journal_title：European journal of pharmacology

authors： O'Leary OF,Dinan TG,Cryan JF

更新日期：2015-04-15 00:00:00

abstract：:The present study was designed to investigate the antinociception of spirocyclopiperazinium salt compound LXM-10-M (2,4-dimethyl-9-β-m-hydroxyphenylethyl-3-oxo-6, 9-diazaspiro [5.5] undecane chloride) in thermal and chemical pain models, and further to explore the molecular target and potential signal pathway. We asse...

journal_title：European journal of pharmacology

authors： Wan D,Wang D,Sun Q,Song Y,Jiang Y,Li R,Ye J

更新日期：2016-01-05 00:00:00

abstract：:The novel substituted benzamide eticlopride, (S)-(-)-5-chloro-3-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxy salicylamide hydrochloride (A38503; FLB 131), was radiolabelled to high specific activity and used for in vivo receptor binding studies in the rat brain. Intravenous injections of [3H]eticlopride resulted...

journal_title：European journal of pharmacology

authors： Köhler C,Hall H,Gawell L

更新日期：1986-01-21 00:00:00

abstract：:Levonorgestrel (13beta-ethyl-17alpha-ethynyl-17beta-hydroxy-4-gonen-3-one), a potent contraceptive progestin stimulates growth and proliferation of cultured breast cancer cells through a receptor-mediated mechanism, even though levonorgestrel does not bind to the oestrogen receptor (ER). To assess whether the oestroge...

journal_title：European journal of pharmacology

authors： Santillán R,Pérez-Palacios G,Reyes M,Damián-Matsumura P,García GA,Grillasca I,Lemus AE

更新日期：2001-09-14 00:00:00

abstract：:Trans-dehydrocrotonin has antiulcerogenic and antitumor activities. A complex of beta-cyclodextrin with dehydrocrotonin was developed to improve the delivery of dehydrocrotonin. Complex in solid state was evaluated using X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermal gravimetric analysis (TG...

journal_title：European journal of pharmacology

authors： Corrêa DH,Melo PS,de Carvalho CA,de Azevedo MB,Durán N,Haun M

更新日期：2005-03-07 00:00:00

abstract：:Platelet aggregation induced in mice or rats by i.v. ADP can be antagonized by oral administration of suloctidil. This effect on platelet behaviour appears to be sufficient to reduce the rate of thrombotic occlusion of the femoral artery in the dog and to protect the rat against occurrence of thrombophlebitis. ...

journal_title：European journal of pharmacology

authors： Roba J,Claeys M,Lambelin G

更新日期：1976-06-01 00:00:00