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A comparison of the anticonvulsant effects of two systemically active enkephalin analogues in rats.

Abstract：

:FK-33,824 (Tyr-D-Ala-Gly-MePhe-Met(O)-ol) and metkephamid (Tyr-D-Ala-Gly-Phe-N(Me)Met-CONH2; LY 127623) are two parenterally active synthetic analogues of the endogenous morphinomimetic pentapeptide, [Met5]-enkephalin. Acute s.c. administration of each analogue raised the seizure threshold in a dose-related manner in rats challenged with flurothyl, a volatile convulsant. The anticonvulsant action was antagonized by a low dose of naloxone (0.10 mg/kg s.c.). FK-33,824 and metkephamid can therefore be classified with typical mu-receptor agonists such as morphine and etorphine in this procedure.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Cowan A,Tortella FC,Adler MW

doi

10.1016/0014-2999(81)90392-7

subject

Has Abstract

pub_date

1981-04-24 00:00:00

pages

117-21

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(81)90392-7

journal_volume

71

pub_type

杂志文章

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