Abstract:
:Vascular smooth muscle cells in culture are capable of secreting endothelin which is a vasoconstrictor and mitogenic peptide. The effect of glucocorticoids on endothelin release from vascular smooth muscle cells of the rat and rabbit aortas was investigated. Micromolar concentrations of dexamethasone and cortisol caused a 2 to 5-fold increase in endothelin release from the two smooth muscle cell types but no such response was observed in endothelial cells of the bovine aorta. Glucocorticoids appear to selectively induce endothelin release from vascular smooth muscle cells and this may be relevant to glucocorticoid-induced hypertension.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Kanse SM,Takahashi K,Warren JB,Ghatei M,Bloom SRdoi
10.1016/0014-2999(91)90641-3subject
Has Abstractpub_date
1991-06-18 00:00:00pages
99-101issue
1eissn
0014-2999issn
1879-0712pii
0014-2999(91)90641-3journal_volume
199pub_type
杂志文章abstract::The effects of neurotensin on focal adhesion kinase were investigated using lung cancer cells. Neurotensin bound with high affinity to large cell carcinoma cell line NCI-H1299 as did neurotensin-(8-13), but not neurotensin-(1-7) or levocabastine. Addition of 100 nM neurotensin to NCI-H1299 cells caused transient tyros...
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