Clozapine potently stimulates mesocortical dopamine neurons.

abstract：:Attempts were made to find whether [3H]batrachotoxinin A 20-alpha-benzoate provides a specific probe for measuring interactions of local anesthetics with the sodium channel complex. [3H]Batrachotoxinin A 20-alpha-benzoate binding, [14C]guanidine and 22Na uptake were investigated in rat brain crude synaptosomal prepara...

journal_title：European journal of pharmacology

authors： Pauwels PJ,Leysen JE,Laduron PM

更新日期：1986-05-27 00:00:00

abstract：:Acanthopanax senticosides B is a monomer of Acanthopanax senticosus saponins. Previous reports showed that Acanthopanax senticosus saponins exhibit antioxidant action and cardiac protection. However, whether Acanthopanax senticosides B has cardiac protection remains unknown. In this study, we investigated the effect o...

journal_title：European journal of pharmacology

authors： Liang Q,Yu X,Qu S,Xu H,Sui D

更新日期：2010-02-10 00:00:00

abstract：:Specific antagonists of platelet-activating factor (PAF) receptors inhibit platelet aggregation and thromboxane synthesis. These two processes have been implicated in the course of diabetic retinopathy. We assessed the effect of a specific PAF receptor antagonist, WEB 2086-BS (3-(4-(2-chlorophenyl)-9-methyl-6H-thieno(...

journal_title：European journal of pharmacology

authors： de la Cruz JP,Moreno A,Ruiz-Ruiz MI,García-Campos J,Sánchez de la Cuesta F

更新日期：1998-10-30 00:00:00

abstract：:Nonalcoholic steatohepatitis (NASH) is one of the most common liver diseases involving chronic accumulation of fat and inflammation, often leading to advanced fibrosis, cirrhosis and carcinoma. However, the pathological mechanism for this is unknown. GPR120/FFAR4 has been recognized as a functional fatty acid receptor...

journal_title：European journal of pharmacology

authors： Nakamoto K,Shimada K,Harada S,Morimoto Y,Hirasawa A,Tokuyama S

更新日期：2018-02-05 00:00:00

abstract：:Nitric oxide (NO) is an antiatherogenic vasodilator synthesized from arginine and, indirectly, from citrulline through argininosuccinate synthase (ASS) and argininosuccinate lyase (ASL). Hypercholesterolemia-induced atherosclerosis is usually treated by statins, which decrease cholesterolemia and increase endothelial ...

journal_title：European journal of pharmacology

authors： Berthe MC,Bernard M,Rasmusen C,Darquy S,Cynober L,Couderc R

更新日期：2011-11-30 00:00:00

abstract：:Plasma adrenaline mainly originates from adrenaline-containing cells in the adrenal medulla, whereas plasma noradrenaline reflects not only the release from sympathetic nerves but also the secretion from noradrenaline-containing cells in the adrenal medulla. The present study was undertaken to examine the mechanisms i...

journal_title：European journal of pharmacology

authors： Shimizu T,Yokotani K

更新日期：2009-03-15 00:00:00

abstract：:Arvanil is a metabolically stable hybrid between anandamide and capsaicin. The present study was designed to test the role of the vagal pathway in post-arvanil respiratory and blood pressure responses. Respiratory and pressure changes evoked by an intravenous injection of arvanil were investigated in 21 urethane-chlor...

journal_title：European journal of pharmacology

authors： Kopczyńska B

更新日期：2010-09-15 00:00:00

abstract：:The effects of the long-term administration of diazepam on the potential difference and short-circuit current of the isolated skin of the toad Pleurodema thaul (P. thaul) were investigated. Diazepam applied in a concentration range of 4.6 x 10(-6) to 5.2 x 10(-5) M decreased both electrical parameters. This response w...

journal_title：European journal of pharmacology

authors： Norris B,Contreras E,Nunez G,Contreras G

更新日期：1995-07-04 00:00:00

abstract：:The pre- and postsynaptic actions of the calcium entry facilitator Bay K 8644 were investigated in the rat isolated vas deferens. Bay K 8644 had no presynaptic effect on adrenergic neurotransmission in the epididymal portion. Bay K 8644 and alpha 1-adrenoceptor agonists potentiated, and the calcium entry blocker nifed...

journal_title：European journal of pharmacology

authors： Hyland L,Warnock P,Docherty JR

更新日期：1984-09-17 00:00:00

abstract：:In this study, we investigated whether spinal noradrenergic and serotonergic systems are involved in the antinociception induced by the novel pyrazolines 3-methyl- and 3-phenyl-5-hydroxy-5-trichloromethyl-4,5-dihydro-1H-1-pyrazole-1-carboxyamide (MPCA and PPCA, respectively), and the pyrazolinone dipyrone in the aceti...

journal_title：European journal of pharmacology

authors： Godoy MC,Fighera MR,Souza FR,Flores AE,Rubin MA,Oliveira MR,Zanatta N,Martins MA,Bonacorso HG,Mello CF

更新日期：2004-08-02 00:00:00

abstract：:MK-886, an inhibitor of the 5-lipoxygenase-activating protein (FLAP), potently suppresses leukotriene biosynthesis in intact cells and is frequently used to define a role of the 5-lipoxygenase (EC 1.13.11.34) pathway in cellular or animal models of inflammation, allergy, cancer, and cardiovascular disease. Here we sho...

journal_title：European journal of pharmacology

authors： Koeberle A,Siemoneit U,Northoff H,Hofmann B,Schneider G,Werz O

更新日期：2009-04-17 00:00:00

abstract：:The pharmacology of neurogenic trigeminovascular vasodilator responses in the dura mater is of interest for understanding the pathophysiology of migraine and to develop new therapies for this disabling common condition. Aminergic mechanisms have been implicated in migraine through direct study of amines in patients, a...

journal_title：European journal of pharmacology

authors： Akerman S,Williamson DJ,Hill RG,Goadsby PJ

更新日期：2001-07-13 00:00:00

abstract：:Inhibition by antipsychotic drugs of voltage-gated L-type Ca2+ channels was characterized in rat neuronal cell line pheochromocytoma PC12 cells. Under whole-cell voltage-clamp, haloperidol and chlorpromazine (1-100 microM) inhibited Ba2+ current permeating through Ca2+ channels. Fluspirilene and pimozide the Ba2+ curr...

journal_title：European journal of pharmacology

authors： Ito K,Nakazawa K,Koizumi S,Liu M,Takeuchi K,Hashimoto T,Ohno Y,Inoue K

更新日期：1996-10-24 00:00:00

abstract：:Mitochondrial oxidative stress followed by membrane permeability transition (MPT) has been considered as a possible mechanism for statins cytotoxicity. Statins use has been associated with reduced risk of cancer incidence, especially prostate cancer. Here we investigated the pathways leading to simvastatin-induced pro...

journal_title：European journal of pharmacology

authors： Costa RA,Fernandes MP,de Souza-Pinto NC,Vercesi AE

更新日期：2013-02-15 00:00:00

abstract：:We have recently shown that short-term aortic barodenervation diminishes constrictor responses to activation of alpha1-adrenoceptors in rat aortic smooth muscle. This study investigated the potential role of vascular endothelium and its derived vasoactive substances, nitric oxide and prostaglandins, in the reduced alp...

journal_title：European journal of pharmacology

authors： El-Mas MM,Daabees TT,El-Gowelli HM,Abdel-Galil AG

更新日期：1997-10-22 00:00:00

abstract：:The effects of drugs that inhibit human ether-a-go-go-related gene (HERG) related cardiac potassium channels on the variability of QT duration as a sign of repolarisation instability were evaluated in conscious telemetered dogs. QT duration variability was determined using a beat-to-beat analysis before and after the ...

journal_title：European journal of pharmacology

authors： Schneider J,Hauser R,Andreas JO,Linz K,Jahnel U

更新日期：2005-04-04 00:00:00

abstract：:Kynuramine increased heart rate and blood pressure in pithed rats. Heart rate responses were blocked by beta-adrenoceptor antagonists and reserpine pretreatment. Both of these treatments reduced the pressor responses to kynuramine. Remaining pressor activity was inhibited by phentolamine. The pressor responses to kynu...

journal_title：European journal of pharmacology

authors： Johnson TD,Clarke DE

更新日期：1983-02-18 00:00:00

abstract：:The effect of colchicine on jejunal adenylate cyclase activity, prostaglandin E2 (PGE2) and cAMP contents, the enzyme and mediators involved in intestinal fluid secretion was tested in rats. Four h after the intraperitoneal injection of colchicine (0.5 mg/100 g body wt.) mucosal PGE2 content, adenylate cyclase activit...

journal_title：European journal of pharmacology

authors： Rachmilewitz D,Karmeli F

更新日期：1980-10-17 00:00:00

abstract：:Paclitaxel, an antitumoral drug, was used in a single dose (29 mg/kg i.p.) as an injury agent for inducing transient suppression of hematopoiesis in a murine experimental model during 10days. The aim of this study focuses on erythropoietin (EPO) receptor, GATA binding protein 1 (globin transcription factor 1) (GATA-1)...

journal_title：European journal of pharmacology

authors： Aguirre MV,Todaro JS,Juaristi JA,Brandan NC

更新日期：2010-06-25 00:00:00

abstract：:The aim of the present study was to investigate the effects of chronic administration of morphine on the expression of an endogenous opioid peptide in the spinal dorsal horn. Bovine adrenal medulla 22-like immunoreactivity (BAM22-IR) was found in the superficial layers of the spinal cord. Intrathecal (i.t.) administra...

journal_title：European journal of pharmacology

authors： Chen P,Liu Y,Hong Y

更新日期：2008-07-28 00:00:00

abstract：:The increases in activity of hepatic thymidylate synthetase and of thymidine kinase, which catalyze the formation of thymidylate via the de novo and salvage pathways, respectively, were significantly suppressed during liver regeneration in rats which had been given alpha-adrenoceptor antagonists (phenoxybenzamine and ...

journal_title：European journal of pharmacology

authors： Nakata R,Tsukamoto I,Nanme M,Makino S,Miyoshi M,Kojo S

更新日期：1985-08-27 00:00:00

abstract：:Receptor for advanced glycation end-products (RAGE) is involved in the pathogenesis of diabetic nephropathy. FPS-ZM1, a selective RAGE inhibitor, in combination with valsartan were investigated for their protective potentials on the renal markers of tubular injury in streptozotocin-induced diabetic rats. Rats were ass...

journal_title：European journal of pharmacology

authors： Sanajou D,Ghorbani Haghjo A,Argani H,Roshangar L,Rashtchizadeh N,Ahmad SNS,Ashrafi-Jigheh Z,Bahrambeigi S,Asiaee F,Rashedi J,Aslani S

更新日期：2019-01-05 00:00:00

abstract：:Levcromakalim was more potent at relaxing rat small mesenteric arteries with endothelium (EC50, 84+/-10 nM) than denuded vessels (EC50, 779+/-101 nM). The cannabinoid receptor antagonist SR 141716A (N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-me thyl-1H-pyrazole-3-carboxamide hydrochloride; 1 microM...

journal_title：European journal of pharmacology

authors： White R,Hiley CR

更新日期：1997-11-27 00:00:00

abstract：:The purpose of this study was to investigate the antioxidant potential of umbelliferone, 7-hydroxy coumarin, and its role in the protection against radiation-induced oxidative damage in cultured human blood lymphocytes. It was found that the antioxidant effect of umbelliferone was dose dependent in hydroxyl (OH(•)), s...

journal_title：European journal of pharmacology

authors： Kanimozhi G,Prasad NR,Ramachandran S,Pugalendi KV

更新日期：2011-12-15 00:00:00

abstract：:We have shown recently that selegiline exerts a cardiac neuroprotective effect in chronic heart failure. Since selegiline has an antioxidant antiapoptotic effect, we proposed to determine whether selegiline attenuates cardiac oxidative stress and myocyte apoptosis in chronic heart failure by modulating Bcl-2 and Bax p...

journal_title：European journal of pharmacology

authors： Qin F,Shite J,Mao W,Liang CS

更新日期：2003-02-14 00:00:00

abstract：:Presynaptic cholinergic markers could be used for estimating the integrity of the cholinergic systems in the human brain with brain imaging techniques such as Single-photon emission computed tomography (SPECT). Vesamicol, an inhibitor of the vesicular acetylcholine transporter, and some of its derivatives have been su...

journal_title：European journal of pharmacology

authors： Custers FG,Leysen JE,Stoof JC,Herscheid JD

更新日期：1997-11-05 00:00:00

abstract：:Antidepressant drugs are currently one of the most prescribed medications. In addition to treatment resistance and side effects of antidepressants, their clinical use is further complicated by antidepressant discontinuation syndrome (ADS). ADS is a common problem in patients following the interruption, dose reduction,...

journal_title：European journal of pharmacology

authors： Zabegalov KN,Kolesnikova TO,Khatsko SL,Volgin AD,Yakovlev OA,Amstislavskaya TG,Alekseeva PA,Meshalkina DA,Friend AJ,Bao W,Demin KA,Gainetdinov RR,Kalueff AV

更新日期：2018-06-15 00:00:00

abstract：:Beat-to-beat alternations of the cardiac monophasic action potential, known as electrical alternans, were studied at drug concentrations that have known arrhythmogenic outcomes. Electrical alternans were elicited from the heart of anesthetized guinea pigs, both in the absence and presence of drugs that inhibit the del...

journal_title：European journal of pharmacology

authors： Fossa AA,Wisialowski T,Wolfgang E,Wang E,Avery M,Raunig DL,Fermini B

更新日期：2004-02-20 00:00:00

abstract：:Atherosclerosis is regarded as chronic inflammatory disease. The IL-6/STAT3 pathway plays an important role in inflammation. We previously described a small-molecule compound, Bazedoxifene, which target IL-6/STAT3 pathway and has been approved for clinical use for osteoporosis in postmenopausal women. The aim of this ...

journal_title：European journal of pharmacology

authors： Luo P,Wang Y,Zhao C,Guo J,Shi W,Ma H,Liu T,Yan D,Huo S,Wang M,Li C,Lin J,Li S,Lv J,Zhang C,Lin L

更新日期：2021-02-15 00:00:00

abstract：:These studies examined the opioid and non-opioid in vivo and in vitro actions of PD117,302 (((±)-trans-N-methyl-N-[2-(l-pyrrolidinyl)-cyclohexyl]benzo[b]thiophene-4-acetamide), a kappa (κ)-opioid receptor agonist. PD117,302 selectively labeled the κ-opioid receptor in guinea pig cerebellar membranes and in mice the ED...

journal_title：European journal of pharmacology

authors： Pugsley MK,Saint DA,Hayes ES,Abraham S,Walker MJ

更新日期：2015-08-15 00:00:00