Effect of chronic administration of morphine on the expression of bovine adrenal medulla 22-like immunoreactivity in the spinal cord of rats.

abstract：:The present study investigated the mechanisms involved in the antinociception produced by the triterpene 3β, 6β, 16β-trihydroxylup-20(29)-ene (TTHL) in mice. TTHL administered by intra-gastric (i.g.) gavage inhibited glutamate-induced nociception with an ID(50) of 19.0 (13.2-27.5) mg/kg. This action started 60 min (in...

journal_title：European journal of pharmacology

authors： Longhi-Balbinot DT,Martins DF,Lanznaster D,Silva MD,Facundo VA,Santos AR

更新日期：2011-02-25 00:00:00

abstract：:The central dopamine system plays a prominent role in the effect of psychostimulants such as methamphetamine, cocaine and nicotine. l-3,4-Dihydroxyphenylalanine (DOPA), a precursor of dopamine, has been proposed as a neurotransmitter in the central nervous system. We have studied the effects of these psychostimulants ...

journal_title：European journal of pharmacology

authors： Izawa J,Yamanashi K,Asakura T,Misu Y,Goshima Y

更新日期：2006-11-07 00:00:00

abstract：:To characterise the safety, tolerability, pharmacodynamics (bronchodilatory effect) and pharmacokinetics of inhaled umeclidinium in patients with chronic obstructive pulmonary disease (COPD). The first investigation was a single dose, randomised, double-blind, placebo-controlled study (clinicaltrials.gov: NCT00515502)...

journal_title：European journal of pharmacology

authors： Tal-Singer R,Cahn A,Mehta R,Preece A,Crater G,Kelleher D,Pouliquen IJ

更新日期：2013-02-15 00:00:00

abstract：:The efficacy of a combinational prophylactic regimen on the lethality, convulsions, and loss of morphological and functional integrities of the brain induced by an organophosphate soman was investigated in rats. The rats were implanted subcutaneously with osmotic minipumps containing the combinational prophylactic reg...

journal_title：European journal of pharmacology

authors： Choi EK,Park D,Yon JM,Hur GH,Ha YC,Che JH,Kim J,Shin S,Jang JY,Hwang SY,Seong YH,Kim DJ,Kim JC,Kim YB

更新日期：2004-11-28 00:00:00

abstract：:The effects of acute treatment with (S)-2-[[(7-fluoroindan-4-yl)oxy]methyl]morpholine monohydrochloride (YM992), venlafaxine, fluoxetine and citalopram on extracellular norepinephrine levels were examined in the rat frontal cortex by in vivo microdialysis. YM992 (3, 10, 30 mg/kg, i.p.) dose-dependently increased extra...

journal_title：European journal of pharmacology

authors： Hatanaka K,Yatsugi S,Yamaguchi T

更新日期：2000-04-21 00:00:00

abstract：:This study uses immediate early transcription factor gene expression to map neuronal activation after a single exposure to the elevated X-maze. Exposure to this novel environment leads to widespread upregulation in the gene expression of c-fos, NGFI-A and NGFI-B (the nerve growth factor induced genes), but not c-jun n...

journal_title：European journal of pharmacology

authors： Hinks GL,Brown P,Field M,Poat JA,Hughes J

更新日期：1996-09-26 00:00:00

abstract：:The impacts of prenatal propofol on cognition and emotion of offspring remain elusive. In the present study, pregnant rats in the second trimester were anesthetized with propofol. Neuronal apoptosis and proliferation was determined in fetuses and postnatal rats by detecting caspase-3 and BrdU expression. The offspring...

journal_title：European journal of pharmacology

authors： Chen D,Qi X,Zhuang R,Cao J,Xu Y,Huang X,Li Y

更新日期：2019-01-15 00:00:00

abstract：:Ohmefentanyl has been shown to be 6300 times more potent than morphine for analgesia. The receptor binding characteristics and distribution of [3H]ohmefentanyl in rat brain sections are presented. [3H]Ohmefentanyl bound with high affinity to opioid receptors in a saturable manner (Kd = 0.95 +/- 0.08 nM, Bmax = 337 +/-...

journal_title：European journal of pharmacology

authors： Wang H,Pélaprat D,Roques BP,Vanhove A,Chi ZQ,Rostène W

更新日期：1991-02-14 00:00:00

abstract：:In the past decade, a growing bulk of evidence has accumulated to suggest that patients suffering from major depression (MD) present some cognitive disturbances, such as impairment in attention, working memory, and executive function, including cognitive inhibition, problem- and task-planning. If the results of short-...

journal_title：European journal of pharmacology

authors： Marazziti D,Consoli G,Picchetti M,Carlini M,Faravelli L

更新日期：2010-01-10 00:00:00

abstract：:In pithed rats, we studied the effects of prostaglandin E2 and of subtype-selective prostaglandin E receptor (EP receptor) ligands on the rise in blood pressure induced by electrical stimulation of the preganglionic sympathetic nerves. Prostaglandin E2, the EP1/EP3 receptor agonist sulprostone and the EP2/EP3 receptor...

journal_title：European journal of pharmacology

authors： Malinowska B,Godlewski G,Buczko W,Schlicker E

更新日期：1994-07-11 00:00:00

abstract：:The effect of papaverine on the positive inotropic response to isopreqaline and to calcium was studied on the rabbit isolated papillary muscle; theophylline and the calcium antagonistic D600 were used for comparison. The dose-response curve for isoprenaline was shifted to the left by papaverine (3 times 10- minus 6 to...

journal_title：European journal of pharmacology

authors： Endoh M,Schümann HJ

更新日期：1975-02-01 00:00:00

abstract：:Sibutramine is a serotonin-norepinephrine reuptake inhibitor indicated for the management of obesity in conjunction with a reduced calorie diet. Though sibutramine was originally evaluated for possible use as an antidepressant, its research development was eventually redirected to evaluate it as an anorexiant. The pha...

journal_title：European journal of pharmacology

authors： Luque CA,Rey JA

更新日期：2002-04-12 00:00:00

abstract：:Antiepileptic and antidepressant drugs are the primary treatments for pain relief in diabetic neuropathy. Combination therapy is a valid approach in pain treatment, where a reduction of doses could reduce side effects and still achieve optimal analgesia. We examined the effects of two-drug combinations of gabapentin, ...

journal_title：European journal of pharmacology

authors： Tomić MA,Vucković SM,Stepanović-Petrović RM,Micov AM,Ugresić ND,Prostran MS,Bosković B

更新日期：2010-02-25 00:00:00

abstract：:Our data indicate that estrogens and progesterone can regulate the number of GABA receptors (as detected by [3H]muscimol binding assay) in rat brain. Both hormones act in selected areas. The extent of the effect (up to 160% increase) and the number of areas responsive suggest that sex hormones may play a very importan...

journal_title：European journal of pharmacology

authors： Maggi A,Perez J

更新日期：1984-08-03 00:00:00

abstract：:The membrane of bullfrog sympathetic ganglion cells was hyperpolarized by a direct action of ACh (more than 0.5 mM) in a solution containing both nicotine (0.24 mM) and atropine (0.14 mM). This ACh hyperpolarization could be imitated by neither carbachol nor bethanechol, suggesting that the ACh hyperpolarization was t...

journal_title：European journal of pharmacology

authors： Koketsu K,Yamamoto K

更新日期：1975-04-01 00:00:00

abstract：:Following pretreatment with 6-OH-dopamine, the sympathetic nerve endings of the iris and skeletal muscle of mice and rats were not longer detectable by cytochemistry for noradrenaline. In the same animals, the specific binding of [3H] ouabain to intact soleus muscles was not significantly different from that measured ...

journal_title：European journal of pharmacology

authors： Clausen T,Hansen O,Larsson LI

更新日期：1981-07-10 00:00:00

abstract：:In the sheep cerebral vasculature 5-hydroxytryptamine (5-HT) caused a contraction of which ketanserin was found to be an effective antagonist (Basilar artery, pA2 = 9.33 +/- 0.16; middle cerebral artery, pA2 = 9.19 +/- 0.16; pial artery, pA2 = 9.47 +/- 0.12). Sumatriptan (GR 43175), a selective 5-HT1-like receptor ago...

journal_title：European journal of pharmacology

authors： Gaw AJ,Wadsworth RM,Humphrey PP

更新日期：1990-04-10 00:00:00

abstract：:Molecular identification of two new transient receptor potential (TRP) channels, TRPM8 and TRPA1, has prompted an intense interest in their functional roles. We report that an acute exposure to the TRPM8/TRPA1 agonist icilin (0.01-100 microM), but not TRPV1 agonist capsaicin (10 microM), causes an atypical dose-relate...

journal_title：European journal of pharmacology

authors： Rawls SM,Gomez T,Ding Z,Raffa RB

更新日期：2007-12-01 00:00:00

abstract：:The anticancer drugs camptothecin (CPT) and topotecan (TPT) are known DNA topoisomerase I inhibitors which cause DNA damage and lead to cell death. In this study we provide evidence that CPT and TPT also interfere with the elements of cytoskeleton - microtubules and actin filaments which could be partly responsible fo...

journal_title：European journal of pharmacology

authors： Wang X,Tanaka M,Krstin S,Peixoto HS,Moura CCM,Wink M

更新日期：2016-10-15 00:00:00

abstract：:The stress-induced hyperthermia procedure, in which effects of drugs on basal (T(1)) and stress-induced body temperature (T(2)) are measured, predicts anxiolytic drug effect. Serotonergic drugs alter these responses and here, we studied the role of 5-HT(1A) receptors in stress-induced hyperthermia by using 5-HT(1A) re...

journal_title：European journal of pharmacology

authors： Van Bogaert M,Oosting R,Toth M,Groenink L,van Oorschot R,Olivier B

更新日期：2006-11-21 00:00:00

abstract：:Hruska et al. (1980) reported that hypophysectomy prevented the onset of dopamine receptor supersensitivity. We have repeated this investigation administering haloperidol (0.75 mg/day) or sulpiride (2 X 15 mg/day) or saline for 17 days, followed by a 3 day drug washout period, to sham-operated or hypophysectomised rat...

journal_title：European journal of pharmacology

authors： Jenner P,Rupniak NM,Hall MD,Dyer R,Leigh N,Marsden CD

更新日期：1981-11-19 00:00:00

abstract：:The cerebellum receives indolaminergic fibers influencing Purkinje cell discharges. Data from our laboratories have demonstrated an endogenous release of serotonin (5-HT) and a Na(+)-dependent uptake and Ca(2+)-dependent release of [3H]5-HT from slices, homogenates and synaptosomal fractions of the rat cerebellar mole...

journal_title：European journal of pharmacology

authors： Beas-Zárate C,Morales-Villagran A,Tapia-Arizmendi G,Feria-Velasco A

更新日期：1991-05-30 00:00:00

abstract：:Pulmonary and systemic hemodynamic effects of delta 9-tetrahydrocannabinol (delta 9-THC) in conscious dogs and in those anesthetized with morphine (3 mg/kg, i.m.) plus alpha-chloralose (100 mg/kg i.v.) were evaluated in this study. A decrease in the heart rate, cardiac output (PBF) and a concomitant increase in the pu...

journal_title：European journal of pharmacology

authors： Jandhyala BS,Hamed AT

更新日期：1978-12-15 00:00:00

abstract：:G protein-coupled receptors (GPCRs) are a family of membrane receptors that regulate physiology and pathology of various organs. Consequently, about 40% of drugs in the market targets GPCRs. Heterotrimeric G proteins are composed of α, β, and γ subunits, and act as the key downstream signaling molecules of GPCRs. The ...

journal_title：European journal of pharmacology

authors： Duc NM,Kim HR,Chung KY

更新日期：2015-09-15 00:00:00

abstract：:5-Hydroxytryptamine (5-HT) mediates intestinal hypersecretion associated with infection and inflammation. We tested the hypothesis that 5-HT-induced anion secretion is mediated by an opioid-sensitive enteric neural circuit. 5-HT, at a contraluminal concentration of 10 microM, increased short-circuit current by 58 +/- ...

journal_title：European journal of pharmacology

authors： Green BT,Brown DR

更新日期：2002-09-13 00:00:00

abstract：:The kappa-opioid receptor agonist, U50,488H (trans-(+-)-3,4-dichloro-N-methyl-[2-(1-pyrrolidinyl)-cyclohexyl]- benzeneacetamide), has recently been reported to induce dystonia after s.c. administration of 5-10 mg/kg in guinea pigs. The dystonic movements observed in response to U50,488H resembled those previously repo...

journal_title：European journal of pharmacology

authors： Richter A,Löscher W

更新日期：1993-05-19 00:00:00

abstract：:The potency of the dihydropyridine calcium channel blocker, PN 200-110 was assessed in vitro against contractions induced by potassium (20-55 mM) and histamine (1-300 microM) in rabbit thoracic aorta, coronary, basilar, renal and central ear arteries. PN 200-110 was particularly effective against potassium responses i...

journal_title：European journal of pharmacology

authors： Bijak A,Pasternac A,McPherson GA,Bevan JA

更新日期：1986-12-16 00:00:00

abstract：:Tricyclic antidepressants not only inhibit monoamine reuptake but also modulate Cys-loop receptors. However, it is not understood how this modulation is involved in their therapeutic effects. We analyzed the mechanisms of inhibition of homomeric 5-HT(3A) and alpha7-5HT(3A) receptors by tricyclic antidepressants at the...

journal_title：European journal of pharmacology

authors： Gumilar F,Bouzat C

更新日期：2008-04-14 00:00:00

abstract：:T-type Ca(2+) currents were recorded in 2 mM Ca(2+) from HEK293 cells stably expressing the low voltage-activated Ca(2+) channel sub-unit alpha(1I). These currents were inhibited by the known Ca(2+) channel antagonist mibefradil with an IC(50) close to 1 microM. SB-209712 (1,6,bis¿1-[4-(3-phenylpropyl)piperidinyl]¿hex...

journal_title：European journal of pharmacology

authors： McNaughton NC,Warre R,Cooper DG,Nasir S,Ranson JL,Randall A

更新日期：2000-10-27 00:00:00

abstract：:Cocaine and several sigma receptor ligands inhibit dopamine uptake via a common site. This is evidenced by a concentration-dependent inhibition of dopamine uptake and displacement of the binding of [3H]WIN 35,428 (also called CFT), a cocaine analog with high affinity for the dopamine transporter. Since several sigma r...

journal_title：European journal of pharmacology

authors： Izenwasser S,Newman AH,Katz JL

更新日期：1993-10-19 00:00:00