Vascular bed and vasoconstrictor-dependent selectivity of the calcium channel antagonist, PN 200-110.

abstract：:In the sheep cerebral vasculature 5-hydroxytryptamine (5-HT) caused a contraction of which ketanserin was found to be an effective antagonist (Basilar artery, pA2 = 9.33 +/- 0.16; middle cerebral artery, pA2 = 9.19 +/- 0.16; pial artery, pA2 = 9.47 +/- 0.12). Sumatriptan (GR 43175), a selective 5-HT1-like receptor ago...

journal_title：European journal of pharmacology

authors： Gaw AJ,Wadsworth RM,Humphrey PP

更新日期：1990-04-10 00:00:00

abstract：:The significance of the blood pressure elevation caused by N(G)-nitro-L-arginine (L-NNA) to inhibitory mechanism of the drug on depressor responses to acetylcholine in anesthetized dogs was investigated. L-NNA (50 mg kg(-1), i.v.) elevated blood pressure to a plateau of 30-50 mm Hg above baseline level and shifted the...

journal_title：European journal of pharmacology

authors： Nakahara T,Nejishima H,Nakayama K,Ishii K

更新日期：1999-06-04 00:00:00

abstract：:Neurotrophic and neuroprotective properties of Hsp70 were studied in olfactory cortex slices of hypertensive rats under normal conditions and under influence of autologous blood (blood clot). Under normal conditions, synaptic response in slices depended on Hsp70 amount in medium. Incubation of slices with Hsp70 showed...

journal_title：European journal of pharmacology

authors： Mokrushin AA,Pavlinova LI

更新日期：2012-02-29 00:00:00

abstract：:Zolpidem has abuse potential, particularly among individuals with histories of drug abuse. This double-blind, placebo-controlled, cross over pilot study investigated the subjective effects of zolpidem (10 mg) in drug-naïve females. Over the course of a 5-h period vital signs were monitored and a series of computerized...

journal_title：European journal of pharmacology

authors： Licata SC,Penetar DM,Dunlap S,Lukas SE

更新日期：2008-11-19 00:00:00

abstract：:In cross-chopped slices from rat thalamus and in the presence of 10 mM LiCl, noradrenaline stimulated the accumulation of [3H]inositol phosphates with [3H]inositol monophosphates ([3H]IP1) being the major product detected (86 +/- 2% of total [3H]inositol phosphates). Noradrenaline-induced [3H]IP1 accumulation was conc...

journal_title：European journal of pharmacology

authors： Trejo F,De la Vega MT,Arias-Montaño JA

更新日期：1996-12-27 00:00:00

abstract：:Mizoribine is a disease-modifying anti-rheumatic drug (DMARD) that is used in the treatment of rheumatoid arthritis. However, clinical use of the drug is restricted to a few Asian countries due to a lack of comprehensive evidence on its effectiveness. The inhibitory effect of the drug on human osteoclastogenesis was i...

journal_title：European journal of pharmacology

authors： Lee YA,Yang HI,Park EK,Bang JS,Choi HM,Oh DH,Lee SH,Hong SJ,Jo YJ,Yoo MC,Kim KS

更新日期：2009-03-01 00:00:00

abstract：:The involvement of delta opioid receptors in supraspinal analgesia was investigated. With this aim, opioids that produced analgesia in the tail immersion test were administered i.c.v. to mice a few minutes before the irreversible antagonist, beta-funaltrexamine (beta-FNA). Protection of the respective analgesic effect...

journal_title：European journal of pharmacology

authors： Sánchez-Blázquez P,Garzón J

更新日期：1989-01-02 00:00:00

abstract：:Ionic currents and contraction were recorded under voltage clamp conditions in single fibres isolated from rat soleus muscles denervated for more than 20 days. The effects of amphiphiles on depolarization-contraction (d.c.) coupling in Na-free TEA-containing solutions were analyzed. An anionic amphiphile, sodium dodec...

journal_title：European journal of pharmacology

authors： Léoty C,Noireaud J

更新日期：1989-12-12 00:00:00

abstract：:1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane (BBSKE, PCT: CN02/00412), a novel thioredoxin reductase inhibitor previously synthesized in our lab, has been demonstrated to inhibit the growth of a variety of human cancer cells and to induce apoptosis. Here we report on the potential molecular mechanism of apopt...

journal_title：European journal of pharmacology

authors： Lan L,Zhao F,Wang Y,Zeng H

更新日期：2007-01-26 00:00:00

abstract：:Inhibition by antipsychotic drugs of voltage-gated L-type Ca2+ channels was characterized in rat neuronal cell line pheochromocytoma PC12 cells. Under whole-cell voltage-clamp, haloperidol and chlorpromazine (1-100 microM) inhibited Ba2+ current permeating through Ca2+ channels. Fluspirilene and pimozide the Ba2+ curr...

journal_title：European journal of pharmacology

authors： Ito K,Nakazawa K,Koizumi S,Liu M,Takeuchi K,Hashimoto T,Ohno Y,Inoue K

更新日期：1996-10-24 00:00:00

abstract：:In the rat pulmonary artery, phorbol 12,13-dibutyrate induces a contraction due to the activation of the protein kinase C. We investigated the sensitivity of this protein kinase C-mediated contraction to a variety of vascular smooth muscle relaxants. Pretreatment of rat pulmonary artery with relaxant compounds altered...

journal_title：European journal of pharmacology

authors： Savineau JP,Gonzalez De La Fuente P,Marthan R

更新日期：1993-11-09 00:00:00

abstract：:Mouse myotubes were used to investigate effects of the nondepolarizing neuromuscular blocking drugs pancuronium and atracurium on embryonic-type nicotinic acetylcholine receptor channels. Experiments were performed using patch-clamp techniques in combination with devices for ultra-fast solution exchange at outside--ou...

journal_title：European journal of pharmacology

authors： Löwenick CV,Krampfl K,Schneck H,Kochs E,Bufler J

更新日期：2001-02-09 00:00:00

abstract：:Endogenous opioid and nociceptin systems are widely distributed in the gastrointestinal tract where they seem to play a crucial role in maintaining the intestinal homeostasis. The aim of our study was to assess whether activation of nociceptin (NOP) and µ-opioid (MOP) receptors by a mixed NOP/MOP receptor agonist, BU0...

journal_title：European journal of pharmacology

authors： Zielińska M,Ben Haddou T,Cami-Kobeci G,Sałaga M,Jarmuż A,Padysz M,Kordek R,Spetea M,Husbands SM,Fichna J

更新日期：2015-10-15 00:00:00

abstract：:Endogenous hydrogen sulfide is produced by cystathionine-γ-lyase and cystathionine-β-synthase in a variety of tissues and has recently been implicated in the regulation of cardiac functions. Acceleration of the heart rate in response to catecholamines is impaired in patients with cirrhosis. The present study was aimed...

journal_title：European journal of pharmacology

authors： Babaei-Karamshahlou M,Hooshmand B,Hajizadeh S,Mani AR

更新日期：2012-12-05 00:00:00

abstract：:The role of endogenous enkephalins in behavioural control in mice was investigated by i.v. injection of RB 101 (N-[(R,S)-2-benzyl-3[(S)(2-amino-4- methylthio)butyl dithio]-1-oxopropyl]-L-phenylalanine benzyl ester). RB 101 is a recently reported systemically active mixed inhibitor prodrug of the two enzymes which meta...

journal_title：European journal of pharmacology

authors： Baamonde A,Daugé V,Ruiz-Gayo M,Fulga IG,Turcaud S,Fournié-Zaluski MC,Roques BP

更新日期：1992-06-05 00:00:00

abstract：:Pharmacological strategies aimed at co-activating peroxisome proliferator-activated receptor-gamma (PPAR-γ)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway have shown promising results in alleviating myocardial injury. The aim of the study was to evaluate the role of chrysin, a PPAR-γ agonist, in ischemia-r...

journal_title：European journal of pharmacology

authors： Rani N,Arya DS

更新日期：2020-09-15 00:00:00

abstract：:The effects of substitutions in the xanthine nucleus on tracheal relaxant activity, atrium chronotropic activity, adenosine A1 affinity, and inhibitory activities on cyclic AMP-phosphodiesterase isoenzymes in guinea pigs were studied. Substitution with a long alkyl chain at the N1-position of xanthine nucleus increase...

journal_title：European journal of pharmacology

authors： Miyamoto K,Kurita M,Ohmae S,Sakai R,Sanae F,Takagi K

更新日期：1994-05-17 00:00:00

abstract：:α1-Adrenoceptor stimulation of mouse aorta causes intracellular Ca(2+) release from sarcoplasmic reticulum Ca(2+) stores via stimulation of inositoltriphosphate (IP3) receptors. It is hypothesized that this Ca(2+) release from the contractile and IP3-sensitive Ca(2+) store is under the continuous dynamic control of ti...

journal_title：European journal of pharmacology

authors： Leloup AJ,Van Hove CE,De Meyer GR,Schrijvers DM,Fransen P

更新日期：2015-08-05 00:00:00

abstract：:Ryanodine at nanomolar concentrations suppressed the earlier of two contraction components which can be produced in guinea-pig papillary muscles, in the presence of noradrenaline (3 microM) at a low contraction frequency (0.2 Hz). However, test contractions elicited shortly after a steady state contraction showed an u...

journal_title：European journal of pharmacology

authors： Vierling W

更新日期：1988-01-19 00:00:00

abstract：:Structurally diverse compounds have been shown to possess high affinities for benzodiazepine receptors in their 'diazepam-sensitive' (DS) conformations. In contrast, only the imidazobenzodiazepinone Ro 15-4513 has been shown to exhibit a high affinity for the 'diazepam-insensitive' (DI) conformation of benzodiazepine ...

journal_title：European journal of pharmacology

authors： Wong G,Skolnick P

更新日期：1992-01-14 00:00:00

abstract：:Pretreatment of chick biventer cervicis preparations with ethanol (290 mM) potentiated the EC50 of choline, acetylcholine, carbachol and phenyltrimethylammonium 91%, 319%, 97% and 213%, respectively. Perhaps this interaction of ethanol and neurotransmitter could contribute to the effects on coordination and motor acti...

journal_title：European journal of pharmacology

authors： Clement JG

更新日期：1980-01-25 00:00:00

abstract：:MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) destroys dopamine-containing nigrostriatal neurons and increases the apparent Bmax of both D1 and D2 binding sites in the striatum. However, the changes of Bmax occur at different intervals after the lesion. Up-regulation of D2 sites becomes evident about 3 weeks aft...

journal_title：European journal of pharmacology

authors： Weihmuller FB,Bruno JP,Neff NH,Hadjiconstantinou M

更新日期：1990-05-16 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) has been identified as a potent and robust metabolic regulator. Administration of recombinant FGF21 protein to rodents and rhesus monkeys exerts strong anti-diabetic effects. Previous studies have demonstrated that FGF21 inhibits glucose output in the rat H4IIE hepatoma cell line. W...

journal_title：European journal of pharmacology

authors： Kong LJ,Feng W,Wright M,Chen Y,Dallas-yang Q,Zhou YP,Berger JP

更新日期：2013-02-28 00:00:00

abstract：:In anaesthetised guinea-pigs, bronchoconstriction induced by vagal nerve stimulation was potentiated by low doses of the antimuscarinic bronchodilator drug, ipratropium (0.01-1.0 microgram/kg); the maximum effect was obtained with 1.0 microgram/kg which doubled the bronchoconstriction. When the dose was increased abov...

journal_title：European journal of pharmacology

authors： Fryer AD,Maclagan J

更新日期：1987-07-09 00:00:00

abstract：:The adult brain has long been viewed as a collection of neuronal networks that maintain a fixed configuration of synaptic connections. Brain plasticity and learning was thought to depend exclusively on changes in the gain and offset of these connections. Over the last 50 years, molecular and cellular studies of neurop...

journal_title：European journal of pharmacology

authors： Holtmaat A,Randall J,Cane M

更新日期：2013-11-05 00:00:00

abstract：:Hypoglycemia developed in fasted rats during forced swimming. This hypoglycemia was mostly abolished by phentolamine, an alpha-adrenolytic agent, or by hexamethonium; was potentiated by propranolol, a beta-adrenolytic agent, of by 5-methoxyindole-2-carboxylic acid, a gluconeogenic inhibitor; and was not affected by an...

journal_title：European journal of pharmacology

authors： Yajima M,Hosokawa T,Ui M

更新日期：1977-03-07 00:00:00

abstract：:Non-peptide antagonists of the NK1 and NK2 receptors were tested as inhibitors of the reaction time in the rat tail-flick and on the decrease of reaction time induced by the intrathecal injection of the NK1 receptor selective agonist [Sar9,Met(O2)11]SP or of the NK2 selective agonist NKA-(4-10). The decrease in reacti...

journal_title：European journal of pharmacology

authors： Picard P,Boucher S,Regoli D,Gitter BD,Howbert JJ,Couture R

更新日期：1993-03-02 00:00:00

abstract：:Mouse GluK5 was expressed in Sf9 insect cells and radiolabelled with [(3)H]-kainate in receptor binding assays (Kd=6.9nM). Western immunoblotting indicated an Sf9 GluK5 band doublet corresponding to the glycosylated (128kDa) and deglycosylated (111kDa) protein, which was identical to the band pattern of native rat bra...

journal_title：European journal of pharmacology

authors： Møllerud S,Kastrup JS,Pickering DS

更新日期：2016-10-05 00:00:00

abstract：:Alzheimer's disease is the most common form of dementia, causing progressive cognitive dysfunction, particularly memory loss. Recently, modulation of beta-amyloid (Abeta) toxicity, one of the major potential causes of Alzheimer's disease, has emerged as a possible therapeutic approach to control the onset of Alzheimer...

journal_title：European journal of pharmacology

authors： Kim HS,Lim JY,Sul D,Hwang BY,Won TJ,Hwang KW,Park SY

更新日期：2009-11-10 00:00:00

abstract：:Guinea pig neurotensin differs from other mammalian neurotensin by the substitution of proline by serine at position 7. [Ser7]neurotensin produced a concentration-dependent contraction of the guinea pig oesophagus and rat fundus, a biphasic effect (initial relaxation followed by more sustained contraction) on the guin...

journal_title：European journal of pharmacology

authors： Katsoulis S,Conlon JM

更新日期：1987-08-21 00:00:00