Abstract:
:Ionic currents and contraction were recorded under voltage clamp conditions in single fibres isolated from rat soleus muscles denervated for more than 20 days. The effects of amphiphiles on depolarization-contraction (d.c.) coupling in Na-free TEA-containing solutions were analyzed. An anionic amphiphile, sodium dodecyl sulfate (1-10 microM), caused a dose-dependent reduction of the contractile response at all amplitudes of depolarization while a cationic amphiphile, dodecyltrimethylamine (1-10 microM), increased the maximum developed tension with a shift in the contractile threshold. A neutral amphiphile, lauryl acetate (20 microM), induced no significant variation. The effects of charged amphiphiles were found to be strongly dependent on the external calcium concentration and on membrane potential. The effect of sodium dodecyl sulfate to decrease tension was reduced or changed to positive inotropy following hyperpolarization of the membrane by, respectively, +10 and +20 mV. In hyperpolarized (+20 mV) cells, dodecyltrimethylamine reduced the amplitude of the contraction. The results demonstrated that changes in Ca-binding properties of surface membrane modified d.c. coupling in denervated slow twitch skeletal muscle.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Léoty C,Noireaud Jdoi
10.1016/0014-2999(89)90878-9subject
Has Abstractpub_date
1989-12-12 00:00:00pages
91-7issue
1eissn
0014-2999issn
1879-0712pii
0014-2999(89)90878-9journal_volume
174pub_type
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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abstract::Excitotoxicity and imbalance of sodium and calcium homeostasis trigger pathophysiologic processes in cerebral ischemia which can accelerate neuronal death. Neuroprotective role of cannabidiol (CBD), one of the main non-psychoactive phytocannabinoids of the cannabis plant, has attracted attention of many researchers in...
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