Ipratropium bromide potentiates bronchoconstriction induced by vagal nerve stimulation in the guinea-pig.

Abstract:

:In anaesthetised guinea-pigs, bronchoconstriction induced by vagal nerve stimulation was potentiated by low doses of the antimuscarinic bronchodilator drug, ipratropium (0.01-1.0 microgram/kg); the maximum effect was obtained with 1.0 microgram/kg which doubled the bronchoconstriction. When the dose was increased above 1.0 microgram/kg potentiation no longer occurred; instead the vagally induced bronchoconstriction was antagonised. This was accompanied by reduction in the bronchoconstriction and bradycardia induced by i.v. acetylcholine, due to blockade of post-junctional muscarinic receptors in the airways and heart. With 10 micrograms/kg ipratropium responses elicited both by vagal stimulation and by exogenous acetylcholine were abolished. The results show that ipratropium is an antagonist for pre-junctional muscarinic inhibitory receptors on pulmonary parasympathetic nerves and also confirm its potent antagonist actions on post-junctional muscarinic receptors in the airway smooth muscle. The effect of ipratropium in the lung depends, therefore, on the balance between the pre- and post-junctional effects.

journal_name

Eur J Pharmacol

authors

Fryer AD,Maclagan J

doi

10.1016/0014-2999(87)90251-2

subject

Has Abstract

pub_date

1987-07-09 00:00:00

pages

187-91

issue

2

eissn

0014-2999

issn

1879-0712

pii

0014-2999(87)90251-2

journal_volume

139

pub_type

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