当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Effect of vascular smooth muscle relaxants on the protein kinase C-mediated contraction in the rat pulmonary artery.

Effect of vascular smooth muscle relaxants on the protein kinase C-mediated contraction in the rat pulmonary artery.

Abstract：

:In the rat pulmonary artery, phorbol 12,13-dibutyrate induces a contraction due to the activation of the protein kinase C. We investigated the sensitivity of this protein kinase C-mediated contraction to a variety of vascular smooth muscle relaxants. Pretreatment of rat pulmonary artery with relaxant compounds altered the subsequent concentration-response curve to phorbol 12,13-dibutyrate (0.05-2 microM) in a variable manner. Isoprenaline (0.1-10 microM), nifedipine (0.01-1 microM) and cromakalim (0.1-10 microM) had no effect, whereas vasoactive intestinal peptide (VIP, 1-10 nM), forskolin (0.1-2 microM), theophylline (0.1-2.5 mM), 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone (RO 20-1724, 2-20 microM), dipyridamole (10-100 microM), 8 bromo-cyclic GMP (8-br-cGMP, 5-500 microM) and dibutyryl cyclic AMP (db-cAMP, 100-500 microM) shifted the concentration-response curve to phorbol 12,13-dibutyrate to the right and decreased the maximal response. When cumulative concentrations of relaxants were applied on the plateau of the contraction induced by 0.2 or 2 microM phorbol 12,13-dibutyrate, again, isoprenaline, nifedipine and cromakalim failed to decrease the protein kinase C-mediated contraction, whereas the other agents produced concentration-dependent relaxation. From their inhibitory effect on the 0.2 microM phorbol 12,13-dibutyrate-induced contraction, the rank order of potency of these relaxants was: VIP > forskolin > RO 20-1724 > 8-br-cGMP > theophylline > dipyridamole > db-cAMP. In chemically (beta escin) skinned preparations, cGMP (5-500 microM) and cAMP (50-1000 microM) antagonized in a concentration dependent manner the contraction induced by phorbol 12,13-dibutyrate at constant Ca2+ concentration.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Savineau JP,Gonzalez De La Fuente P,Marthan R

doi

10.1016/0014-2999(93)90432-h

subject

Has Abstract

pub_date

1993-11-09 00:00:00

pages

191-8

issue

2

eissn

0014-2999

issn

1879-0712

pii

0014-2999(93)90432-H

journal_volume

249

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF PHARMACOLOGY文献大全
  • Effects of cannabinoid receptor stimulation and blockade on catalepsy produced by dopamine receptor antagonists.

    abstract：:The ability of cannabinoid receptor stimulation or blockade to alter catalepsy produced by dopamine D1 and D2 receptor antagonists was studied in rats. The cannabinoid receptor antagonist SR 141716A (N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-me thyl-1H- pyrazole-3-carboxamidehydrochloride) (0.5 an...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(95)00661-3

    authors： Anderson JJ,Kask AM,Chase TN

    更新日期：1996-01-11 00:00:00

  • Comparative therapeutic effects of metformin and vitamin E in a model of non-alcoholic steatohepatitis in the young rat.

    abstract：:Only in the last few years has non-alcoholic steatohepatitis been recognized as an important and relatively common liver disease. To date, the therapeutic options are limited, vitamin E and metformin have been proposed for the treatment of this condition, although their mechanisms are not completely clarified as yet. ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2008.12.013

    authors： Raso GM,Esposito E,Iacono A,Pacilio M,Cuzzocrea S,Canani RB,Calignano A,Meli R

    更新日期：2009-02-14 00:00:00

  • Chronic mianserin treatment decreases 5-HT2 receptor binding without altering 5-HT2 receptor mRNA levels.

    abstract：:Rats were injected with 15 mg/kg (i.p.) mianserin or vehicle (saline) for 4, 10 or 21 days and 5-HT2 receptor binding and mRNA levels measured. Treatment with mianserin induced a substantial decrease in 5-HT2 radioligand binding (44-59% decrease; P less than 0.05 vs. control). No changes in the amount of 5-HT2 or, as ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0922-4106(91)90093-w

    authors： Roth BL,Ciaranello RD

    更新日期：1991-06-19 00:00:00

  • Newly identified structurally disparate modulators of osmosensitive taurine efflux inhibit cell cycle progression.

    abstract：:FACS analysis and [14C]-taurine efflux were used to determine whether activation of the volume-sensitive organic osmolyte/anion channel plays a role in cell cycle progression. This was achieved by examining the effects of a collection of (i) H(1) antagonists and tricyclic antidepressants with a known inhibitory effect...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(03)02073-9

    authors： Belsey MJ,Culliford SJ,Morley RM,Witchel HJ,Kozlowski RZ

    更新日期：2003-08-08 00:00:00

  • The effect of O-1602, a GPR55 agonist, on the cyclophosphamide-induced rat hemorrhagic cystitis.

    abstract：:The goal of our study was to determine whether GPR55 agonists, O-1602, could reverse the cyclophosphamide (CYP)-induced changes in cystometric and inflammatory parameters, indicative of the development of bladder inflammation and overactivity. If confirmed, the stimulation of novel cannabinoid receptor - GPR55, could ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2020.173321

    authors： Wróbel A,Zapała Ł,Zapała P,Piecha T,Radziszewski P

    更新日期：2020-09-05 00:00:00

  • Selective and complete blockade of acetylcholine-induced relaxation in rabbit aortic rings by N omega-nitro-L-arginine but not by glybenclamide.

    abstract：:This study addressed the possibility that acetylcholine-induced relaxation in the rabbit aorta is mediated by dual mechanisms: one N omega-nitro-L-arginine (NLA)-sensitive, the other glybenclamide-sensitive. Acetylcholine, nitroglycerin and BRL38227 (lemakalim), an activator of glybenclamide-sensitive potassium channe...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(93)90964-j

    authors： Bellan JA,Longenecker LL,Kadowitz PJ,McNamara DB

    更新日期：1993-04-06 00:00:00

  • Fading and tachyphylaxis to the contractile effects of substance P in the guinea-pig ileum.

    abstract：:Substance P (SP) caused an immediate and vigorous contraction of the longitudinal smooth muscle layer of the guinea-pig ileum. The contractile response to SP, unlike that to acetylcholine or histamine was not maintained but faded to baseline levels in about 6 min. When 0.3-1.0 nM SP was added the fading time was short...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(82)90597-0

    authors： Huidobro-Toro JP,Chelala CA,Bahouth S,Nodar R,Musacchio JM

    更新日期：1982-06-16 00:00:00

  • Antioxidant effect of erythropoietin on 1-methyl-4-phenylpyridinium-induced neurotoxicity in PC12 cells.

    abstract：:The neuroprotective effects of erythropoietin on 1-methyl-4-phenylpyridinium (MPP(+))-induced oxidative stress and apoptosis in cultured PC12 cells as well as the underlying mechanism were investigated. Treatment of PC12 cells with MPP(+) caused the loss of cell viability, which was associated with the elevation in ap...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2007.02.020

    authors： Wu Y,Shang Y,Sun S,Liu R

    更新日期：2007-06-14 00:00:00

  • Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum.

    abstract：:Ginger (rhizomes of Zingiber officinale) has been shown to exert potent anti-emetic properties, but its mode of action has not yet been elucidated. Among its active constituents, [6]-, [8]- and [10]-gingerol as well as [6]-shogaol were shown in different in vivo studies to be at least partly responsible for the drug's...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2005.10.049

    authors： Abdel-Aziz H,Windeck T,Ploch M,Verspohl EJ

    更新日期：2006-01-13 00:00:00

  • Protection by atropine of the inhibition caused by Triton X-100 on central muscarinic receptors.

    abstract：:Synaptosomal membranes from cat cerebral cortex were labelled with [3H]-quinuclidinyl benzylate ([3H]QNB). There was shown to be a single type of binding site with Kd = 0.34 nM, Bmax = 2.2 nmol/g protein and Hill No. = 1.01. Triton X-100 at 5 x 10(-4)% inhibited the specific binding of [3H]QNB and the inhibition was a...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(80)90252-6

    authors： Aguilar JS,Criado M,De Robertis E

    更新日期：1980-05-16 00:00:00

  • Differentiation-inducing factor-1-induced growth arrest of K562 leukemia cells involves the reduction of ERK1/2 activity.

    abstract：:The differentiation-inducing factor-1 (DIF-1) is a signal molecule that induces stalk cell differentiation in the cellular slime mold Dictyostelium discoideum. In addition, DIF-1 is a potent antileukemic agent that induces growth arrest in K562 cells. In this study, we investigated the mechanism of action of DIF-1 in ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2003.11.041

    authors： Akaishi E,Narita T,Kawai S,Miwa Y,Sasaguri T,Hosaka K,Kubohara Y

    更新日期：2004-02-06 00:00:00

  • Electrophysiological effect and the gating mechanism of astragaloside IV on L-type Ca(2+) channels of guinea-pig ventricular myocytes.

    abstract：:Astragaloside IV (AS-IV) is one of the main active ingredients of Astragalus membranaceus. This study is aimed to investigate AS-IV׳s effects on Ca(2+) channel activity of single cardiomyocytes and single Ca(2+) channels. Whole-cell Ca(2+) currents in freshly dissociated cardiomyocytes were measured using the whole-ce...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2015.03.082

    authors： Zhao M,Shao D,Yu L,Sun X,Wang Y,Hu H,Feng R,Gao Q,Guo F,Hao L

    更新日期：2015-08-05 00:00:00

  • The pharmacological activity of berberine, a review for liver protection.

    abstract：:Liver plays an important role in bile synthesis, metabolic function, degradation of toxins, new substances synthesis in body. However, hepatopathy morbidity and mortality are increasing year by year around the world, which become a major public health problem. Traditional Chinese medicine (TCM) has a prominent role in...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejphar.2020.173655

    authors： Zhou M,Deng Y,Liu M,Liao L,Dai X,Guo C,Zhao X,He L,Peng C,Li Y

    更新日期：2021-01-05 00:00:00

  • Inotropic and chronotropic responses to inosine in isolated and blood-perfused dog atria.

    abstract：:The effects of inosine on sinus rate and atrial contractile force were investigated using the isolated and blood-perfused canine atrium which was perfused with arterial blood from a donor dog. Injected inosine (100-3000 micrograms) consistently induced positive chronotropic and inotropic effects. However, the larger d...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(80)90174-0

    authors： Furukawa Y,Chiba S

    更新日期：1980-10-31 00:00:00

  • Tricyclic antidepressants activate the pituitary-adrenal axis in the rat. Tolerance to repeated drug administration.

    abstract：:The effects of acute chronic administration of tricyclic antidepressants on the pituitary-adrenal axis were studied in adult male rats. Acute administration of desipramine, imipramine and chlorimipramine activated the pituitary-adrenal axis. The effect of imipramine was found to be of short duration with a significant...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(87)90812-0

    authors： Armario A,García-Marquez C

    更新日期：1987-08-11 00:00:00

  • The inhibitory effect of opioid and alpha 2-adrenoceptor agonists on cardiac sensory neurones is pertussis toxin-insensitive.

    abstract：:The role of pertussis toxin-sensitive G proteins on the alpha 2-adrenoceptor and mu-opioid receptor-mediated inhibition of the efferent function of capsaicin-sensitive neurones was investigated in guinea-pig atria pretreated with guanethidine. In the presence of atropine, CGP 20712A (2-hydroxy-5-(2-[hydroxy-3-(4-[(1-m...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(92)90444-9

    authors： Amerini S,Rubino A,Mantelli L,Filippi S,Ledda F

    更新日期：1992-06-17 00:00:00

  • Loss of amitriptyline analgesia in alpha 2A-adrenoceptor deficient mice.

    abstract：:Tricyclic antidepressants have analgesic and sedative effects in addition to their antidepressive properties. We tested the acute analgesic and locomotor inhibitory effects of the tricyclic antidepressant amitriptyline and the alpha(2)-adrenoceptor agonist clonidine in wild-type control and in alpha(2A)-adrenoceptor k...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2003.11.047

    authors： Ozdoğan UK,Lähdesmäki J,Mansikka H,Scheinin M

    更新日期：2004-02-06 00:00:00

  • Characterization of angiotensin II antagonism displayed by Ib, a novel nonpeptide angiotensin AT(1) receptor antagonist.

    abstract：:The pharmacologic profile of Ib, 5-n-butyl-4-{4-[2-(1H-tetrazole-5-yl)-1H-pyrrol-1-yl]phenylmethyl}-2,4-dihydro-2-(2,6-dichloridephenyl)-3H-1,2,4-triazol-3-one, a novel nonpeptide angiotensin AT(1) receptor antagonist, was investigated by receptor-binding studies, functional in vitro assays with rabbit and rat aorta, ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2008.05.007

    authors： Wu J,Wang Q,Guo J,Hu Z,Yin Z,Xu J,Wu X

    更新日期：2008-07-28 00:00:00

  • Platycodin D alleviates liver fibrosis and activation of hepatic stellate cells by regulating JNK/c-JUN signal pathway.

    abstract：:Liver fibrosis is involved in the progression of most chronic liver diseases. Even though we have made a huge progress in order to understand the pathogenesis of liver fibrosis, however, there is still a lack of productive treatments. Being a traditional Chinese medicine, Platycodin D (PD), an oleanane kind of triterp...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2020.172946

    authors： Liu YM,Cong S,Cheng Z,Hu YX,Lei Y,Zhu LL,Zhao XK,Mu M,Zhang BF,Fan LD,Yu L,Cheng ML

    更新日期：2020-06-05 00:00:00

  • Cadmium: effects on transmitter release at the frog neuromuscular junction.

    abstract：:Cd2+ competitively antagonizes Ca2+ in the evoked release of acetylcholine from nerve terminals in the frog sciatic-sartorius neuromuscular junction. The dissociation constant between Cd2+ and its receptor sites was calculated to be 1.7 microM. In agreement with previous work we found that brief exposures to 100-500 m...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(84)90131-6

    authors： Cooper GP,Manalis RS

    更新日期：1984-04-06 00:00:00

  • The actions of benzophenanthridine alkaloids, piperonyl butoxide and (S)-methoprene at the G-protein coupled cannabinoid CB₁ receptor in vitro.

    abstract：:This investigation focused primarily on the interaction of two benzophenanthridine alkaloids (chelerythrine and sanguinarine), piperonyl butoxide and (S)-methoprene with G-protein-coupled cannabinoid CB(1) receptors of mouse brain in vitro. Chelerythrine and sanguinarine inhibited the binding of the CB(1) receptor ago...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2010.11.033

    authors： Dhopeshwarkar AS,Jain S,Liao C,Ghose SK,Bisset KM,Nicholson RA

    更新日期：2011-03-01 00:00:00

  • Protective effects of antithrombin on puromycin aminonucleoside nephrosis in rats.

    abstract：:We investigated the effects of antithrombin, a plasma inhibitor of coagulation factors, in rats with puromycin aminonucleoside-induced nephrosis, which is an experimental model of human nephrotic syndrome. Antithrombin (50 or 500 IU/kg/i.v.) was administered to rats once a day for 10 days immediately after the injecti...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2008.04.065

    authors： Yamashita J,Nakajima K,Ohno Y,Kaneshiro Y,Matsuo T,Tanaka H,Kaneko K

    更新日期：2008-07-28 00:00:00

  • Evidence of the involvement of dopamine in the analgesic effect of nefopam.

    abstract：:The involvement of brain monoamines in the mechanism of action of nefopam, a new analgesic, was investigated in rats. The study was designed to evaluate the effect of various means of impairing monoaminergic transmission on nefopam analgesia as measured with the hot plate method. Pretreatment with reserpine (2 mg/kg) ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(86)90762-4

    authors： Esposito E,Romandini S,Merlo-Pich E,Mennini T,Samanin R

    更新日期：1986-09-09 00:00:00

  • Evidence for a cortical locus for the stimulus effect of nicotine.

    abstract：:This study investigated the stimulus properties of nicotine in the rat with the objective of determining the time course of the nicotine-produced interoceptive cue and its relationship to specific brain levels of the drug. The behavioral task employed was shock-escape in a T-maze apparatus. After the injection of nico...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(75)90226-5

    authors： Schechter MD,Jellinek P

    更新日期：1975-11-01 00:00:00

  • Full and partial agonistic behaviour and thermodynamic binding parameters of adenosine A1 receptor ligands.

    abstract：:The inhibitory effect of forskolin-stimulated 3',5'-cyclic monophosphate (c-AMP) synthesis in isolated rat adipocytes has been measured for eight typical adenosine receptor agonists. The percent inhibition was evaluated using concentrations of each compound corresponding to 100 times their Ki, inhibitory binding const...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0922-4106(94)90224-0

    authors： Borea PA,Varani K,Dalpiaz A,Capuzzo A,Fabbri E,IJzerman AP

    更新日期：1994-03-15 00:00:00

  • Effects of alpha-adrenoceptor agents on norepinephrine release from vas deferens of several species including man.

    abstract：:Unlike the situation with the vas deferens of rats, guinea-pigs, rabbits and dogs, neither phentolamine nor yohimbine enhanced electrically-evoked release of [3H]norepinephrine from the in vitro human vas deferens. However, clonidine produced, by a phentolamine-sensitive mechanism, a concentration-related inhibition o...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(82)90495-2

    authors： Belis JA,Colby JE,Westfall DP

    更新日期：1982-03-26 00:00:00

  • The neuronal KCNQ channel opener retigabine inhibits locomotor activity and reduces forebrain excitatory responses to the psychostimulants cocaine, methylphenidate and phencyclidine.

    abstract：:Many central stimulating drugs have a pronounced stimulatory effect on striatal and cortical activity which is associated to enhanced function of mesencephalic dopaminergic neurons. Mesencephalic KCNQ (also termed K(v)7) potassium channels suppress the basal activity of dopaminergic neurons in the substantia nigra and...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2007.05.029

    authors： Hansen HH,Andreasen JT,Weikop P,Mirza N,Scheel-Krüger J,Mikkelsen JD

    更新日期：2007-09-10 00:00:00

  • In vitro profile of the antidepressant candidate OPC-14523 at rat and human 5-HT1A receptors.

    abstract：:This study determined the in vitro functional profile of 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate (OPC-14523) at rat and human serotonin (5-HT) 5-HT1A receptors and binding affinity of OPC-14523 at human frontocortical 5-HT1A receptors. OPC-14523 (1 microM...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2005.05.035

    authors： Jordan S,Chen R,Koprivica V,Hamilton R,Whitehead RE,Tottori K,Kikuchi T

    更新日期：2005-07-11 00:00:00

  • KF17837: a novel selective adenosine A2A receptor antagonist with anticataleptic activity.

    abstract：:KF17837 is a novel selective adenosine A2A receptor antagonist. Oral administration of KF17837 (2.5, 10.0 and 30.0 mg/kg) significantly ameliorated the cataleptic responses induced by intracerebroventricular administration of an adenosine A2A receptor agonist, CGS 21680 (10 micrograms), in a dose-dependent manner. KF1...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(94)90551-7

    authors： Kanda T,Shiozaki S,Shimada J,Suzuki F,Nakamura J

    更新日期：1994-05-02 00:00:00

  • Baroreceptor-induced decrease in muscle blood flow upon propranolol administration.

    abstract：:The acute effects of propranolol, 1 mg/kg i.v., were studied in chloralosed, vagotomized cats. The vascularly isolated but innervated calf muscles were perfused from another animal. In one group of experiments, the carotid baroreceptors were exposed to ambient arterial pressure. Here, propranolol caused a fall in hear...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(78)90361-8

    authors： Lisander B,Nilsson H

    更新日期：1978-08-01 00:00:00