Ethanol potentiation of choline, acetylcholine, carbachol and phenyltrimethylammonium contractions in the chick biventer cervicis muscle.

abstract：:Major depression is a highly prevalent disorder and is predicted to be the second leading cause of disease burden by 2020. Although many antidepressant drugs are currently available, they are far from optimal. Approximately 50% of patients do not respond to initial first line antidepressant treatment, while approximat...

journal_title：European journal of pharmacology

authors： O'Leary OF,Dinan TG,Cryan JF

更新日期：2015-04-15 00:00:00

abstract：:Although a number of muscarinic agonists have been used in clinical trials for Alzheimer's Disease, many of these compounds are low in potency and have only limited intrinsic efficacy. The present study describes four non-quaternary oxadiazole based muscarinic agonists from a quinuclidine and a 1-azanorbornane series....

journal_title：European journal of pharmacology

authors： Freedman SB,Harley EA,Marwood RS,Patel S

更新日期：1990-10-09 00:00:00

abstract：:Calcium entry blockers can effectively preserve high-energy phosphates in ischemic heart. However, little is known about the optimal timing of drug therapy. The moment of nisoldipine administration in relation to its protective efficacy during ischemia and reperfusion was studied in rat hearts. Nisoldipine (50 nM), gi...

journal_title：European journal of pharmacology

authors： De Jong JW

更新日期：1985-11-26 00:00:00

abstract：:A series of tertiary amines structurally related to the potent muscarinic agent oxotremorine showed weak stimulant activity on the frog rectus abdominis preparation. The corresponding quaternary ammonium salts were more effective stimulants, the most potent being half as active as carbachol. The effects appeared to be...

journal_title：European journal of pharmacology

authors： Ringdahl B

更新日期：1984-03-23 00:00:00

abstract：:meta-Substituted 2-chlorophenyl(imino)imidazolidines of the clonidine-type (2,3- and 2,5-substituted derivatives) were used in attempts to discriminate between alpha-adrenergic effects (central hypotensive and peripheral hypertensive activities) in rats. The central hypotensive activity of four pairs of substitution i...

journal_title：European journal of pharmacology

authors： de Jonge A,Slothorst-Grisdijk FP,Timmermans PB,Van Zwieten PA

更新日期：1981-05-22 00:00:00

abstract：:The affinity and intrinsic activity of dopamine receptor agonists were determined at the human dopamine hD21 and hD4.4 receptors. (-)-3-Hydroxy-N-n-propylpiperidine ((-)3-PPP) had an intrinsic activity of 46% and 83%, whereas (+)-N-propylnorapomorphine ((+)-NPA) had intrinsic activities of 61% and 58% at the dopamine ...

journal_title：European journal of pharmacology

authors： Lahti RA,Mutin A,Cochrane EV,Tepper PG,Dijkstra D,Wikström H,Tamminga CA

更新日期：1996-04-22 00:00:00

abstract：:Several lines of evidence point to the association of vitamin D deficiency with the different components of metabolic syndrome. Yet, the effect of vitamin D supplementation on metabolic syndrome is not clearly elucidated. Herein, we tested the hypothesis that administration of vitamin D, either alone or in combination...

journal_title：European journal of pharmacology

authors： Mostafa DK,Nasra RA,Zahran N,Ghoneim MT

更新日期：2016-12-05 00:00:00

abstract：:The effects of indapamide on contractile responses in various isolated artery rings and on spontaneous mechanical activity in portal vein segments were investigated. Arteries used were: rabbit aorta, mesenteric (fifth branch), femoral and basilar, and sheep coronary arteries. 45Ca2+ uptake was also analysed in rabbit ...

journal_title：European journal of pharmacology

authors： Del Rio M,Chulia T,Gonzalez P,Tejerina T

更新日期：1993-11-30 00:00:00

abstract：:The outcome for both in-hospital and out-of hospital cardiac arrest remains dismal. Vasopressors are used to increase coronary perfusion pressure and thus facilitate return of spontaneous circulation during cardiopulmonary resuscitation. However, they are associated with a number of potential adverse effects and may d...

journal_title：European journal of pharmacology

authors： Stefaniotou A,Varvarousi G,Varvarousis DP,Xanthos T

更新日期：2014-07-05 00:00:00

abstract：:Thirteen Ca2+ entry blockers were compared with respect to their inhibitory effects on the activity of smooth muscle myosin light-chain kinase and smooth muscle protein kinase C, and the Ca2+-induced contraction of basilar artery rings. Comparison of the IC50 values obtained for these compounds, suggests that with the...

journal_title：European journal of pharmacology

authors： Schächtele C,Wagner B,Rudolph C

更新日期：1989-04-12 00:00:00

abstract：:Several lines of evidence suggest that acetylcholinesterase inhibitors (AChE) have their cognitive enhancing effects by stimulating cholinergic receptors within the medial septum. However, intraseptal administration of cholinergic enhancing drugs produce mixed results that appear to depend on both the integrity of the...

journal_title：European journal of pharmacology

authors： Roland JJ,Levinson M,Vetreno RP,Savage LM

更新日期：2010-03-10 00:00:00

abstract：:Thoracic preganglionic sympathetic nerve activity, blood pressure, heart rate and femoral arterial conductance were recorded in anaesthetised, paralysed cats. Cumulative dose-response curves were constructed for 8-OH-DPAT, ipsapirone and clonidine. All three drugs caused dose-related falls in blood pressure which were...

journal_title：European journal of pharmacology

authors： Ramage AG,Fozard JR

更新日期：1987-06-19 00:00:00

abstract：:Increasing evidence indicates that brain inflammation is involved in the pathogenesis of neuropsychiatric diseases. Mast cells (MCs) are located perivascularly close to neurons and microglia, primarily in the leptomeninges, thalamus, hypothalamus and especially the median eminence. Corticotropin-releasing factor (CRF)...

journal_title：European journal of pharmacology

authors： Theoharides TC,Stewart JM,Panagiotidou S,Melamed I

更新日期：2016-05-05 00:00:00

abstract：:We previously reported that glycoxidized low-density lipoprotein (glycoxidized LDL) enhanced monocyte chemoattractant protein-1 (MCP-1) mRNA expression through activation of nuclear factor-kappaB (NF-kappaB). Here we investigated the effects of dilazep, an anti-platelet agent, and fenofibric acid, an active metabolite...

journal_title：European journal of pharmacology

authors： Sonoki K,Iwase M,Iino K,Ichikawa K,Yoshinari M,Ohdo S,Higuchi S,Iida M

更新日期：2003-08-15 00:00:00

abstract：:The role of nitric oxide and cyclo-oxygenase products in the platelet-activating factor (PAF)-induced hyporesponsiveness to noradrenaline was investigated in pithed rats. Infusion of PAF (30 ng/kg/min) for 60 min reduced the mean arterial blood pressure and impaired the pressor responses to noradrenaline (10 ng/kg, 10...

journal_title：European journal of pharmacology

authors： Shiga T,Yoshikawa D

更新日期：1995-08-25 00:00:00

abstract：:Effects of histamine receptor ligands on the glibenclamide-sensitive K+ currents induced by K+ channel openers, cromakalim and Y-26763, were examined in follicle-enclosed Xenopus oocytes. Histamine H1 receptor antagonists, promethazine, dimethindene and chlorpheniramine all decreased cromakalim-induced K+ currents wit...

journal_title：European journal of pharmacology

authors： Sakuta H

更新日期：1994-01-01 00:00:00

abstract：:Effects of protein kinase C inhibitors, staurosporine and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride and protein tyrosine kinase inhibitors, genistein, tyrphostin and 2,5-dimethylcinnamate on the neutrophil responses stimulated by immunoglobulin G (IgG), complement C5a or platelet-activating factor...

journal_title：European journal of pharmacology

authors： Ahn SK,Shin YK,Kang HJ,Han ES,Lee CS

更新日期：1996-06-13 00:00:00

abstract：:The ability of the prostacyclin (IP) receptor agonist cicaprost to activate Gs-, Gq/11- and Gi-mediated cell signalling pathways has been examined in Chinese hamster ovary (CHO) cells and human embryonic kidney 293 (HEK 293) cells expressing the cloned human (hIP) or mouse (mIP) prostacyclin receptor, and compared wit...

journal_title：European journal of pharmacology

authors： Chow KB,Jones RL,Wise H

更新日期：2003-08-01 00:00:00

abstract：:In the present study, the effects of dopamine receptor agonists and antagonists on naloxone-induced jumping in morphine-dependent mice were examined. Mice were rendered dependent as described in the methods section. Naloxone was injected to elicit jumping (as withdrawal sign). The first group received dopamine recepto...

journal_title：European journal of pharmacology

authors： Zarrindast MR,Habibi M,Borzabadi S,Fazli-Tabaei S,Hossein Yahyavi S,Rostamin P

更新日期：2002-09-20 00:00:00

abstract：:Our previous research showed that ATP and adenosine 5'-O-2-thiodiphosphate (ADPbetaS) induce contractile effects in the longitudinal muscle of mouse distal colon via activation of P2Y receptors which are not P2Y(1) or P2Y(12) subtypes. This study investigated the nature of the P2Y receptor subtype(s) and the mechanism...

journal_title：European journal of pharmacology

authors： Zizzo MG,Mulè F,Serio R

更新日期：2008-10-24 00:00:00

abstract：:Numerous studies have demonstrated the stimulatory effect of 5-HT1A receptor agonists, such as 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), on plasma corticotrophin (ACTH) levels in the rat. However, until recently the lack of a selective 5-HT1A receptor antagonist has hampered mechanistic studies in this area....

journal_title：European journal of pharmacology

authors： Critchley DJ,Childs KJ,Middlefell VC,Dourish CT

更新日期：1994-10-13 00:00:00

abstract：:Transient outward K+ current, Ito, contributes to cardiac action potential generation and is primarily carried by Kv4.3 (KCND3) channels. Two Kv4.3 isoforms are expressed in human ventricle and show differential remodeling in heart failure (HF). Lidocaine and mexiletine may be applied in selected patients to suppress ...

journal_title：European journal of pharmacology

authors： Rahm AK,Müller ME,Gramlich D,Lugenbiel P,Uludag E,Rivinius R,Ullrich ND,Schmack B,Ruhparwar A,Heimberger T,Weis T,Karck M,Katus HA,Thomas D

更新日期：2020-08-05 00:00:00

abstract：:The role of prostaglandins in the secretion of inhibin and oestradiol-17 beta was examined in immature female rats treated with equine chorionic gonadotrophin. Administration of prostaglandin (PG) F2 alpha to animals whose serum and ovarian levels of inhibin and oestradiol-17 beta had been suppressed by indomethacin g...

journal_title：European journal of pharmacology

authors： Kogo H,Takasaki K,Takeo S,Watanabe G,Taya K,Sasamoto S

更新日期：1993-02-16 00:00:00

abstract：:In this study, we examined the effects of Salvia miltiorrhiza (Danshen) crude extract, some of its lipid-soluble components (tanshinone I, tanshinone II(A), cryptotanshinone, dihydroisotanshinone I) and the water-soluble compounds (danshensu and salvianolic acid B) on the K(+) channels such as the iberiotoxin-sensitiv...

journal_title：European journal of pharmacology

authors： Lam FF,Seto SW,Kwan YW,Yeung JH,Chan P

更新日期：2006-09-28 00:00:00

abstract：:This study investigated sex-related differences in rat papillary muscle force generation in response to altered extracellular [Ca2+] ([Ca2+](o), 0.2 to 5.0 mM) and to L-type Ca2+ channel modulators (nifedipine and Bay K8644). At all [Ca2+]o examined, contractile force was significantly greater in male than female papi...

journal_title：European journal of pharmacology

authors： Curl CL,Delbridge LM,Wendt IR

更新日期：2008-05-31 00:00:00

abstract：:The effects of caffeine on Ca2+ fluxes and catecholamine secretion in bovine adrenal chromaffin cells were examined. Caffeine inhibited secretion. 45Ca2+ uptake and cytosolic Ca2+ concentration ([Ca2+]i) rise induced by the nicotinic receptor agonist 1.1-dimethyl- 4-phenylpiperazinium (DMPP) and the Na+ channel activa...

journal_title：European journal of pharmacology

authors： Liu PS,Lin YJ,Kao LS

更新日期：1995-11-30 00:00:00

abstract：:The potencies of histamine and methacholine were significantly increased by approximately 2- and 5-fold respectively in human non-diseased isolated bronchi on removal of the epithelium. In contrast, no increases in spasmogen potency were observed following epithelium removal in bronchi obtained from a sample of asthma...

journal_title：European journal of pharmacology

authors： Fernandes LB,Preuss JM,Paterson JW,Goldie RG

更新日期：1990-10-23 00:00:00

abstract：:The effects of endothelin-1 on normal and everted rabbit aorta rings and on cultured rat aortic smooth muscle cells were studied. Endothelin-1 (40 nM) contracted both normal and everted rings, and was still able to induce a prolonged contraction in Ca2(+)-free medium. Treatment of cultured cells with 100 nM endothelin...

journal_title：European journal of pharmacology

authors： Miasiro N,Paiva AC

更新日期：1990-04-10 00:00:00

abstract：:Attempts were made to find whether [3H]batrachotoxinin A 20-alpha-benzoate provides a specific probe for measuring interactions of local anesthetics with the sodium channel complex. [3H]Batrachotoxinin A 20-alpha-benzoate binding, [14C]guanidine and 22Na uptake were investigated in rat brain crude synaptosomal prepara...

journal_title：European journal of pharmacology

authors： Pauwels PJ,Leysen JE,Laduron PM

更新日期：1986-05-27 00:00:00

abstract：:The present studies examined the relationship between the blockade of central alpha1-adrenoceptors, as measured by ex vivo binding of [3H]prazosin in the cerebral cortex and the inhibition of behavioral activation to a mildly novel environment (cage change). It was found that intraventricular (i.v.t.) terazosin, a sal...

journal_title：European journal of pharmacology

authors： Stone EA,Rosengarten H,Lin Y,Quartermain D

更新日期：2001-05-25 00:00:00