Abstract:
:The effects of caffeine on Ca2+ fluxes and catecholamine secretion in bovine adrenal chromaffin cells were examined. Caffeine inhibited secretion. 45Ca2+ uptake and cytosolic Ca2+ concentration ([Ca2+]i) rise induced by the nicotinic receptor agonist 1.1-dimethyl- 4-phenylpiperazinium (DMPP) and the Na+ channel activator veratridine. The inhibitory effect of caffeine on high K(+)-induced secretion was smaller than that on DMPP- and veratridine-induced responses. Caffeine only slightly inhibited high K(+)-induced 45Ca2+ uptake and did not affect [Ca2+]i rise. Caffeine also inhibited muscarinic receptor-mediated inositol phosphate generation. Our results suggest that the inhibitory effects of caffeine on bovine chromaffin cells mainly occur at both muscarinic and nicotinic receptors as well as at the voltage-dependent Na+ channels and to a smaller extent at site(s) distal to Ca2+ entry. The effects of caffeine on nicotinic receptors but not on muscarinic receptors can be explained by its ability to raise intracellular cAMP.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Liu PS,Lin YJ,Kao LSdoi
10.1016/0922-4106(95)90066-7subject
Has Abstractpub_date
1995-11-30 00:00:00pages
265-72issue
3eissn
0014-2999issn
1879-0712journal_volume
291pub_type
杂志文章abstract::Hruska et al. (1980) reported that hypophysectomy prevented the onset of dopamine receptor supersensitivity. We have repeated this investigation administering haloperidol (0.75 mg/day) or sulpiride (2 X 15 mg/day) or saline for 17 days, followed by a 3 day drug washout period, to sham-operated or hypophysectomised rat...
journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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