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Rat vena cava alpha 1B-adrenoceptors: characterization by [3H]prazosin binding and contraction experiments.

Abstract：

:We examined which subtypes of alpha 1-adrenoceptors are expressed in rat vena cava by using both functional and [3H]prazosin binding experiments. Pretreatment with chloroethylclonidine inactivated about 80% of the specific [3H]prazosin binding sites and reduced the maximal noradrenaline-induced contraction to the same extent. Competition with subtype-selective agonists and antagonists showed primarily the alpha 1B-adrenoceptor subtype in vena cava. The number of alpha 1-adrenoceptors estimated with [3H]prazosin binding and the maximal noradrenaline-induced contraction were dose-dependently inhibited by phenoxybenzamine, indicating the absence of receptor reserve for noradrenaline in vena cava. As the noradrenaline-induced contraction was largely inhibited in Ca(2+)-free solution, these results suggest that alpha 1B-adrenoceptors can be mainly linked to Ca2+ influx in rat vena cava.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Sayet I,Neuilly G,Rakotoarisoa L,Mironneau J,Mironneau C

doi

10.1016/0922-4106(93)90042-8

subject

Has Abstract

pub_date

1993-08-15 00:00:00

pages

275-81

issue

3

eissn

0014-2999

issn

1879-0712

journal_volume

246

pub_type

杂志文章

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