Effect of chronic moderate ethanol consumption on heart brain natriuretic peptide.

abstract：:An iron-free diet for 28 days caused a reduced level of iron in the blood. Iron deficient rats exhibited a lower level of motor activity and reversed circadian rhythms of thermoregulation and motor activity. The hypothermic effect of d-amphetamine was significantly reduced in iron deficient rats, and the magnitude of ...

journal_title：European journal of pharmacology

authors： Youdim MB,Yehuda S,Ben-Uriah Y

更新日期：1981-09-24 00:00:00

abstract：:The effect of carbachol (10(-3)M) on the membrane potential of rat diaphragm muscle fibres near and remote from the endplate has been investigated by means of a microelectrode technique. In the endplate region a rather slow depolarization was observed followed by spontaneous repolarization. Outside the endplate region...

journal_title：European journal of pharmacology

authors： Mooij JJ,Evers CD,Ras R

更新日期：1976-06-01 00:00:00

abstract：:The aim of the present study was to investigate the contribution of extracellular signal regulated kinase-1/2 (ERK1/2) to pulmonary artery contraction in response to 4-aminopyridione (4-AP), an inhibitor of a voltage-gated K(+) channels that regulate pulmonary vascular tone. Pulmonary artery rings 1-1.5 mm in diameter...

journal_title：European journal of pharmacology

authors： Han W,Tang X,Wu H,Liu Y,Zhu D

更新日期：2007-08-13 00:00:00

abstract：:We compared hypolocomotion and catalepsy mediated by striatal dopamine D2 and adenosine A2A receptors using microinfusions of the adenosine A2A receptor agonist 2-p-(2-carboxyethyl) phenethylamino-5'-N-ethylcarboxamidoadenosine hydrochloride (CGS21680) and the dopamine D2 receptor antagonist raclopride into the nucleu...

journal_title：European journal of pharmacology

authors： Hauber W,Münkle M

更新日期：1997-04-04 00:00:00

abstract：:The purpose of this study was to delineate the distribution of beta-adrenoceptor density in the cat heart, with an emphasis on areas within the left ventricle. beta-Adrenoceptor densities, determined for hearts obtained from five cats, were not significantly different in the left and rights atria, i.e. 47.6 +/- 7.2 an...

journal_title：European journal of pharmacology

authors： Lathers CM,Levin RM,Spivey WH

更新日期：1986-10-14 00:00:00

abstract：:It has been shown that the pancreatic beta-cell monoamines are located in the secretory granules, and that they have an inhibitory influence on insulin secretion. Monoamines are inactivated by the enzyme, monoamine oxidase. We now studied in vivo the relation between adrenergic and cholinergic stimulation, insulin sec...

journal_title：European journal of pharmacology

authors： Panagiotidis G,Stenström A,Lundquist I

更新日期：1993-03-23 00:00:00

abstract：:Vancomycin (VCM) is a first-line antibiotic for serious infections caused by methicillin-resistant Staphylococcus aureus. However, nephrotoxicity is one of the most complaint in VCM therapy. We previously reported that VCM induced apoptosis in a porcine proximal tubular epithelial cell line (LLC-PK1), in which mitocho...

journal_title：European journal of pharmacology

authors： Sakamoto Y,Yano T,Hanada Y,Takeshita A,Inagaki F,Masuda S,Matsunaga N,Koyanagi S,Ohdo S

更新日期：2017-04-05 00:00:00

abstract：:The present studies examined the relationship between the blockade of central alpha1-adrenoceptors, as measured by ex vivo binding of [3H]prazosin in the cerebral cortex and the inhibition of behavioral activation to a mildly novel environment (cage change). It was found that intraventricular (i.v.t.) terazosin, a sal...

journal_title：European journal of pharmacology

authors： Stone EA,Rosengarten H,Lin Y,Quartermain D

更新日期：2001-05-25 00:00:00

abstract：:Immunocytochemical and Co(2+) uptake studies revealed that in primary cultures of rat cortical neurones, the majority of neurones are gamma-aminobutyric acid (GABA) immunopositive and can express Ca(2+)-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors. By fura-2 microfluorimetry, it...

journal_title：European journal of pharmacology

authors： Fischer W,Franke H,Scheibler P,Allgaier C,Illes P

更新日期：2002-03-01 00:00:00

abstract：:Intravenous administration of E. coli lipopolysaccharide (LPS) inhibited the migration of neutrophils into the pleural cavity that occurs following challenge with intrapleural carrageenin. Treatment of animals with levamisole (10 mg/kg i.p.) 30 min after the intravenous administration of LPS almost restored carrageeni...

journal_title：European journal of pharmacology

authors： Rocha NP,Ferreira SH

更新日期：1986-03-11 00:00:00

abstract：:The cerebral circulation is innervated by calcitonin gene-related peptide (CGRP) containing fibers originating in the trigeminal ganglion. During a migraine attack, there is a release of CGRP in conjunction with the head pain, and triptan administration abolishes both the CGRP release and the pain at the same time. In...

journal_title：European journal of pharmacology

authors： Edvinsson L,Sams A,Jansen-Olesen I,Tajti J,Kane SA,Rutledge RZ,Koblan KS,Hill RG,Longmore J

更新日期：2001-03-09 00:00:00

abstract：:Glutamatergic abnormalities are involved in several psychiatric disorders. Clinical evidence demonstrates altered glutamatergic neurotransmission in patients suffering from obsessive-compulsive disorder. MGS0039, (1R,2R,3R,5R,6R)-2-amino-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, is ...

journal_title：European journal of pharmacology

authors： Shimazaki T,Iijima M,Chaki S

更新日期：2004-10-06 00:00:00

abstract：:Renal hemodynamics were studied using an electromagnetic perivascular flow sensor in anesthetized rats injected i.v. with vehicle, 5 or 10 mg/kg body weight (b.w.) sulindac. No hemodynamic changes occurred with vehicle (n = 6), but mean arterial pressure was significantly decreased (by 15 mmHg) with sulindac (n = 12)....

journal_title：European journal of pharmacology

authors： Kramp RA,Caron N,Genard J,Lejeune C,Gulbis E,Herman A

更新日期：1997-07-09 00:00:00

abstract：:In bovine aortic endothelial cells (BAEC), pertussis toxin (PTx) ADP-ribosylated two major substrates with apparent molecular masses of 40 and 41 kDa, whereas cholera toxin (CTx) ADP-ribosylated two other substrates of 44 and 50 kDa. [alpha-32P]GTP bound to three bands in the 22-27 kDa range. Immunoblot analysis revea...

journal_title：European journal of pharmacology

authors： Gil-Longo J,Dufour MN,Guillon G,Lugnier C

更新日期：1993-10-15 00:00:00

abstract：:We have analyzed the effect of quinolizidine alkaloids from Lupinus species upon insulin secretion. Isolated normal rat islets were incubated with 3.3, 8.3, and 16.7 mM glucose, in the presence or absence of different concentrations of lupanine (0.05, 0.5, and 1.0 mM), 13-alpha-OH lupanine, 17-oxo-lupanine, and 2-thio...

journal_title：European journal of pharmacology

authors： García López PM,de la Mora PG,Wysocka W,Maiztegui B,Alzugaray ME,Del Zotto H,Borelli MI

更新日期：2004-11-03 00:00:00

abstract：:Serotonin 1A receptor agonists have attracted much interest recently as potential therapeutic agents for levodopa-induced motor complications, such as dyskinesia and motor fluctuations. The effects of piclozotan (SUN N4057) on a rat model of advanced Parkinson's disease were investigated. Parkinsonian rats, unilateral...

journal_title：European journal of pharmacology

authors： Tani Y,Ogata A,Koyama M,Inoue T

更新日期：2010-12-15 00:00:00

abstract：:The actions of the substituted benzamide derivatives metoclopramide, clebopride, YM-09151-2, tiapride, (+)- and (-)-sulpiride and (+)- and (-)-sultopride, and the dopamine antagonists haloperidol and domperidone, were studied on the responses to field stimulation (0.125-10 Hz) of smooth muscle strips taken from cardia...

journal_title：European journal of pharmacology

authors： Costall B,Naylor RJ,Tan CC

更新日期：1984-06-15 00:00:00

abstract：:The beta-carboline FG 7142 was studied alone and in combination with Ro 15-1788, CGS 8216 and lorazepam in squirrel monkeys trained to respond under a fixed-interval (FI) schedule of food presentation. FG 7142 (0.3-5.6 mg/kg i.v.) produced dose-related decreases in the rate of FI responding, effects opposite to those ...

journal_title：European journal of pharmacology

authors： Wettstein JG

更新日期：1989-04-25 00:00:00

abstract：:The neuroprotective effects of verbascoside, one of phenylpropanoid glucoside isolated from the Chinese herbal medicine Buddleja officinalis Maxim, on 1-methyl-4-phenylpyridinium ion (MPP(+)) induced apoptosis and oxidative stress in PC12 neuronal cells were investigated. Treatment of PC12 cells with MPP(+) for 48 h i...

journal_title：European journal of pharmacology

authors： Sheng GQ,Zhang JR,Pu XP,Ma J,Li CL

更新日期：2002-09-13 00:00:00

abstract：:TL-99 and 3-PPP, two putative dopamine autoreceptor agonists, effectively suppressed serum prolactin (PRL) concentrations in rats treated with alpha-methyltyrosine. In addition, the secretion of PRL from anterior pituitary tissue under in vitro conditions was significantly inhibited by TL-99 and 3-PPP. These findings ...

journal_title：European journal of pharmacology

authors： Gudelsky GA,Passaro E,Meltzer HY

更新日期：1983-06-17 00:00:00

abstract：:Hypovolemic shock was produced in rats by withdrawing about 50% of the estimated total blood volume. Following mean arterial pressure stabilization in the range of 22-23 mm Hg, the rats were given an i.v. bolus injection of L-6-ketopiperidine-2-carbonyl-L-leucyl-L-proline amide (RGH-2202) to be compared with thyrotrop...

journal_title：European journal of pharmacology

authors： Coppi G,Falcone A

更新日期：1990-06-21 00:00:00

abstract：:Endothelin-1-(1-31) is a new bioactive 31-amino-acid-length peptide generated from big endothelin-1 by chymase or other chymotrypsin-type proteases with various pathophysiologic functions. In this study, we have detected the specific and monophasic binding of [125I]endothelin-1-(1-31) in porcine lung membranes. Compet...

journal_title：European journal of pharmacology

authors： Kitamura H,Cui P,Sharmin S,Yano M,Kido H

更新日期：2003-03-28 00:00:00

abstract：:We have previously shown that sigma-2 receptors are relatively difficult to solubilize (Eur. J. Pharmacol. 304 (1996) 201), suggesting possible localization in detergent-resistant lipid raft domains. Rat liver membranes were treated on ice with 1% Triton X-100 or 20 mM 3-[(3-cholamidopropyl)dimethylammonio]-1-propanes...

journal_title：European journal of pharmacology

authors： Gebreselassie D,Bowen WD

更新日期：2004-06-16 00:00:00

abstract：:Pain is a global health challenge. For decades, we have been primarily relying upon opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) for pain management. However, adverse effects related to opioid and NSAID use are severe and often lead to forced drug discontinuation and inadequate pain relief. Despite decade...

journal_title：European journal of pharmacology

authors： Li JX,Zhang Y

更新日期：2012-04-15 00:00:00

abstract：:Terfenadine, a histamine H(1) receptor antagonist, has been associated with clinical ventricular arrhythmias and in vitro excitation-conduction blocks, whereas anti-ischemic and antiarrhythmic effects have been shown with cicletanine, a prostacyclin generation stimulator. We aimed at determining in vitro if cicletanin...

journal_title：European journal of pharmacology

authors： Criniti A,Picard S,Monti F,Dawodu AA,Ruvolo G,Puddu PE,Campa PP

更新日期：1999-10-15 00:00:00

abstract：:Vagal motor outflow from the dorsal vagal complex is important in the regulation of intestinal motility. The aim of our study was to test the hypothesis that within the dorsal vagal complex, tonic GABA(A)-receptor mediated neurotransmission modulates intestinal motility. The GABA(A) receptor antagonist, bicuculline (m...

journal_title：European journal of pharmacology

authors： Greenwood-Van Meerveld B,Barron KW

更新日期：1998-04-10 00:00:00

abstract：:The relationship between morphine tolerance and pituitary-adrenocortical activity was examined. In rats made tolerant to morphine by implantation of morphine-containing pellets, there was a significant reduction in plasma levels of beta-endorphin-like immunoreactivity (beta-END-LI), whereas no significant changes in c...

journal_title：European journal of pharmacology

authors： Antonio Martínez J,Vargas ML,Fuente T,Del Rio Garcia J,Milanés MV

更新日期：1990-06-21 00:00:00

abstract：:We investigated the effect of probucol, a lipid-lowering agent with antioxidant properties, on HCl plus ethanol-induced gastric mucosal injury and on the healing of acetic acid-induced gastric ulcers in rats. When the free radical-scavenging activity of probucol was measured by an electron spin resonance technique, th...

journal_title：European journal of pharmacology

authors： Ito M,Suzuki Y,Ishihara M,Suzuki Y

更新日期：1998-08-07 00:00:00

abstract：:The inhibitory effect of forskolin-stimulated 3',5'-cyclic monophosphate (c-AMP) synthesis in isolated rat adipocytes has been measured for eight typical adenosine receptor agonists. The percent inhibition was evaluated using concentrations of each compound corresponding to 100 times their Ki, inhibitory binding const...

journal_title：European journal of pharmacology

authors： Borea PA,Varani K,Dalpiaz A,Capuzzo A,Fabbri E,IJzerman AP

更新日期：1994-03-15 00:00:00

abstract：:The effects of the unilateral application of d-amphetamine, benztropine, haloperidol and thioproperazine to one substantia nigra on the release of 3H-dopamine (3H-DA) in the two caudate nuclei were examined in halothane-anesthetized cats. For this purpose animals were implanted with push-pull cannulae and 3H-DA was es...

journal_title：European journal of pharmacology

authors： Nieoullon A,Cheramy A,Leviel V,Glowinski J

更新日期：1979-01-15 00:00:00