Quinolizidine alkaloids isolated from Lupinus species enhance insulin secretion.

abstract：:Isoprostaglandin F(2alpha) type-III (formerly known as 8-iso-prostaglandin F(2alpha)) is produced in large quantities in vivo in clinical situations associated with oxidant stress such as atherosclerosis, hypercholesterolemia, and myocardial reperfusion. Isoprostaglandin F(2alpha) type-III may alter smooth muscle and ...

journal_title：European journal of pharmacology

authors： Cracowski JL,Stanke-Labesque F,Devillier P,Chavanon O,Hunt M,Souvignet C,Bessard G

更新日期：2000-05-26 00:00:00

abstract：:We examined the feasibility of coupling the 5-HT(6) receptor to a Ca(2+) signaling read-out using a chimeric G-protein, comprising of G(alphaq) with the C-terminal five amino acids from G(alphas), to facilitate assays on the fluorometric imaging plate reader (FLIPR). Using a transient transfection assay in human embry...

journal_title：European journal of pharmacology

authors： Zhang JY,Nawoschik S,Kowal D,Smith D,Spangler T,Ochalski R,Schechter L,Dunlop J

更新日期：2003-07-04 00:00:00

abstract：:Histone deacetylases (HDACs) can regulate cancer progression and its inhibitors (HDACIs) have been widely used for cancer therapy. Valproic acid (VPA, 2-propylpentanoic acid) can inhibit the class I HDAC and suppress the malignancy of solid cancers. Our present study revealed that 1 mM VPA, which has no effect on cell...

journal_title：European journal of pharmacology

authors： Zhang S,Tang Z,Qing B,Tang R,Duan Q,Ding S,Deng D

更新日期：2019-12-15 00:00:00

abstract：:The characteristics of histamine H1-receptors on astrocytes from the cerebral cortex of newborn rats in primary culture were analyzed with a [3H]mepyramine binding assay, and compared with those in the cerebral cortex. The apparent dissociation constant (KD) of [3H]mepyramine binding, the apparent inhibition constants...

journal_title：European journal of pharmacology

authors： Inagaki N,Fukui H,Taguchi Y,Wang NP,Yamatodani A,Wada H

更新日期：1989-11-28 00:00:00

abstract：:The effect of cytokines on the induction of contractile endothelin ET(B) receptors during organ culture was examined. Ring segments of rat superior mesenteric artery were used fresh or incubated for 24 h in Dulbecco's modified Eagle's medium alone, or with either interleukin-1beta, tumor necrosis factor-alpha (TNF-alp...

journal_title：European journal of pharmacology

authors： Uddman E,Möller S,Adner M,Edvinsson L

更新日期：1999-07-09 00:00:00

abstract：:Bilateral injections of alpha-methylnoradrenaline into the area of the nucleus tractus solitarii of the brain stem caused a dose-dependent decrease of systemic arterial blood pressure and heart rate of anesthetized rats. The effects were prevented and even reversed by a preceding injection of the alpha-adrenoceptor bl...

journal_title：European journal of pharmacology

authors： Nijkamp FP,De Jong W

更新日期：1975-06-01 00:00:00

abstract：:The effect of moguisteine, a novel peripherally acting non-narcotic antitussive drug, on allergic coughs was examined in guinea pigs. Male Hartley guinea pigs were actively sensitized to ovalbumin. The number of coughs elicited over 5 min following a 2-min exposure to ovalbumin was counted. Exposure of sensitized guin...

journal_title：European journal of pharmacology

authors： Kamei J,Morita K,Kashiwazaki T,Ohsawa M

更新日期：1998-04-24 00:00:00

abstract：:Gaboxadol (THIP; 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) is an agonist at GABA(A) receptors. THIP concentrations (0.01-50 mM) were applied rapidly to Sf9 cells expressing the human alpha(1)beta(2)gamma(2S) GABA(A) receptors. The EC(50) values for the peak current in THIP alone or THIP plus 1 microM diazepam we...

journal_title：European journal of pharmacology

authors： Smith M,Lindquist CE,Birnir B

更新日期：2003-09-30 00:00:00

abstract：:GABAA receptors are pentameric chloride ion channels that are opened by GABA. We have screened a cell line derived from human glioblastoma, U3047MG, for expression of GABAA receptor subunit isoforms and formation of functional ion channels. We identified GABAA receptors subunit α2, α3, α5, β1, β2, β3, δ, γ3, π, and θ ...

journal_title：European journal of pharmacology

authors： Babateen O,Jin Z,Bhandage A,Korol SV,Westermark B,Forsberg Nilsson K,Uhrbom L,Smits A,Birnir B

更新日期：2015-02-05 00:00:00

abstract：:Taurine influx in the perfused rat heart was characterized and the effect of isoproterenol on this process determined. Hearts were perfused by the Langendorff technique with [3H]-taurine in a non-recirculating system. The rate of taurine influx was constant for at least 20 min and the process was saturable. A Km of 45...

journal_title：European journal of pharmacology

authors： Chubb J,Huxtable R

更新日期：1978-04-15 00:00:00

abstract：:To assess the role of the alpha 7 neuronal nicotinic acetylcholine receptor in the discriminative stimulus properties of (-)-nicotine, this study investigated the ability of the alpha 7 receptor antagonist methyllycaconitine to modulate the nicotine cue. In rats trained to discriminate (-)-nicotine from saline, intrap...

journal_title：European journal of pharmacology

authors： Brioni JD,Kim DJ,O'Neill AB

更新日期：1996-04-22 00:00:00

abstract：:1,2,3,4-Tetrahydroisoquinoline (TIQ) is an exo- and endogenous amine naturally present in mammalian brain which displays antidepressant-like effect in various animal models: the forced swim test (FST) and chronic mild stress (CMS) paradigm in rats. To elucidate this action we compared the effects of TIQ with imipramin...

journal_title：European journal of pharmacology

authors： Możdżeń E,Papp M,Gruca P,Wąsik A,Romańska I,Michaluk J,Antkiewicz-Michaluk L

更新日期：2014-04-15 00:00:00

abstract：:It has been previously found that the systemic administration of low doses of N-methyl-D-aspartate (NMDA) in mice induces motor depression. The effects of the systemic administration of different doses of NMDA (10, 30 and 60 mg/kg s.c.) on the motor activity and on the in vivo extracellular levels of adenosine in the ...

journal_title：European journal of pharmacology

authors： Melani A,Corsi C,Giménez-Llort L,Martínez E,Ogren SO,Pedata F,Ferré S

更新日期：1999-11-26 00:00:00

abstract：:Itching is known as a commonly side effect of opioid administration. However, the relationship of opioid receptors to itching is unclear. In this study, we examined the effect of intradermal injection of morphine and fentanyl on the itching sensation. When injected intradermally into the rostral back of mice, morphine...

journal_title：European journal of pharmacology

authors： Yamamoto A,Kuyama S,Kamei C,Sugimoto Y

更新日期：2010-02-10 00:00:00

abstract：:LK 204-545 ((+/-)-1-(2-(3-(2-cyano-4-(2-cyclopropyl-methoxy-ethoxy)phenoxy)-2-hydro xy-propyl-amino)-ethyl)-3-(4-hydrxy-phenyl) urea), an antagonist that possesses high beta1-/beta2-selectivity in the rat, and a range of cardio-selective and non-selective beta-adrenoceptor antagonists were examined to compare their ra...

journal_title：European journal of pharmacology

authors： Louis SN,Nero TL,Iakovidis D,Jackman GP,Louis WJ

更新日期：1999-02-19 00:00:00

abstract：:To examine whether low concentrations of endothelin-1 potentiate the vasoconstrictor response to adrenergic stimulation, we recorded the isometric response of rings of rabbit pulmonary artery to electrical stimulation and noradrenaline. Endothelin-1 (10(-10) M) potentiated the contractions induced by electrical stimul...

journal_title：European journal of pharmacology

authors： Vila JM,Medina P,Segarra G,Aldasoro M,Noguera I,Lluch S

更新日期：2001-02-16 00:00:00

abstract：:Lung fibrosis is a common side effect of the chemotherapeutic agent, bleomycin. Current evidence suggests that reactive oxygen species may play a key role in the development of lung fibrosis. The present study examined the effect of mesna on bleomycin-induced lung fibrosis in rats. Animals were divided into three grou...

journal_title：European journal of pharmacology

authors： El-Medany A,Hagar HH,Moursi M,At Muhammed R,El-Rakhawy FI,El-Medany G

更新日期：2005-02-10 00:00:00

abstract：:In WI-38 human fibroblasts, interleukin-1 beta and tumour necrosis factor-alpha (TNF-alpha) increased bradykinin B(1) receptor mRNA, which peaked between 2 and 4 h, remaining elevated for 20 h. Binding of the bradykinin B(1) receptor selective ligand [3H]des-Arg(10)-kallidin, also increased, peaking at 4 h and remaini...

journal_title：European journal of pharmacology

authors： Phagoo SB,Yaqoob M,Herrera-Martinez E,McIntyre P,Jones C,Burgess GM

更新日期：2000-06-02 00:00:00

abstract：:It has been reported that Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) can modulate opioid tolerance via its action on learning and memory. In this study, we examine if CaMKII can directly affect opioid tolerance. We found that spinal CaMKII activity was increased in rats tolerant to morphine. In these rats,...

journal_title：European journal of pharmacology

authors： Wang ZJ,Tang L,Xin L

更新日期：2003-03-28 00:00:00

abstract：:Nine C2-substituted adenosine analogues that are potent and selective for the A2-adenosine receptor were tested for their ability to induce relaxations of the guinea pig aorta. Compounds tested were 2-phenylethoxyadenosine (PEA), 2-phenylethoxy-5'-N-ethylcarboxamidoadenosine (PENECA), 2-cyclohexylethoxyadenosine (CEA)...

journal_title：European journal of pharmacology

authors： Martin PL

更新日期：1992-06-05 00:00:00

abstract：:Using radioligand binding techniques and human frontal cortex, we determined the equilibrium dissociation constants (KDs) of 17 neuroleptics at the serotonin 5-HT1A and serotonin 5-HT2 receptors with [3H]WB4101 and [3H]ketanserin, respectively. At the serotonin 5-HT1A receptor, the most and least potent neuroleptics w...

journal_title：European journal of pharmacology

authors： Wander TJ,Nelson A,Okazaki H,Richelson E

更新日期：1987-11-10 00:00:00

abstract：:The adult brain has long been viewed as a collection of neuronal networks that maintain a fixed configuration of synaptic connections. Brain plasticity and learning was thought to depend exclusively on changes in the gain and offset of these connections. Over the last 50 years, molecular and cellular studies of neurop...

journal_title：European journal of pharmacology

authors： Holtmaat A,Randall J,Cane M

更新日期：2013-11-05 00:00:00

abstract：:In our continuing search to discover bioactive compounds from natural products, we isolated six new clerodane diterpenes, caseamembrins A to F, from Casearia membranacea and examined their antiproliferative activities in human hormone-resistant prostate cancer PC-3 cells. All of these compounds displayed effective ant...

journal_title：European journal of pharmacology

authors： Huang DM,Shen YC,Wu C,Huang YT,Kung FL,Teng CM,Guh JH

更新日期：2004-10-25 00:00:00

abstract：:Adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, adenine and inosine were injected intradermally into the backs of human volunteers. ATP, ADP and AMP evoked weal and flare responses in the skin in a dose dependent manner. The rank order of potency was ATP greater tha...

journal_title：European journal of pharmacology

authors： Coutts AA,Jorizzo JL,Eady RA,Greaves MW,Burnstock G

更新日期：1981-12-17 00:00:00

abstract：:The actions of dequalinium have been investigated in cultured rat sympathetic neurones. It produced a rapid and reversible inhibition of the slow apamin-sensitive component of the afterhyperpolarization (AHP) which follows a single action potential in these cells. The IC50 for this effect was 1.1 microM and in voltage...

journal_title：European journal of pharmacology

authors： Dunn PM

更新日期：1994-02-03 00:00:00

abstract：:The effects of H 25 and H 74 on ouabain-resistant 86Rb+ influx were tested in beta-cell-rich mouse pancreatic islets. Both H 25, which is considered to be a specific inhibitor of Na+, K+, Cl- co-transport, and H 74, a specific inhibitor of K+, Cl- co-transport, reduced the ouabain-resistant 86Rb+ influx. The specific ...

journal_title：European journal of pharmacology

authors： Sandström PE,Sehlin J

更新日期：1993-07-20 00:00:00

abstract：:Galangin, a flavonol derived from Alpinia officinarum Hance and used as food additives in southern China, induces apoptosis and autophagy to suppress the proliferation of HepG2 cells. In this study, we demonstrated that galangin induced autophagy by increasing the ratio of AMP/TAN in HepG2 cells. It stimulated the pho...

journal_title：European journal of pharmacology

authors： Zhang H,Li N,Wu J,Su L,Chen X,Lin B,Luo H

更新日期：2013-10-15 00:00:00

abstract：:Inflammation has been reported to be closely related to exaggeration of cerebral ischemia and neurodegenerative diseases. Microglia, resident immune cells in the central nervous system, can be activated in response to neuronal injury and produce proinflammatory cytokines, resulting in further aggravation of neuronal i...

journal_title：European journal of pharmacology

authors： Hara H,Kimoto D,Kajita M,Takada C,Kamiya T,Adachi T

更新日期：2017-01-15 00:00:00

abstract：:There is increasing evidence in support of an important role played by neurotensin (NT), a tridecapeptide originally found in bovine hypothalamus, in regulation of cardiovascular system. Elevated systemic levels of NT may contribute to pathogenesis of acute circulatory disoders, and predict the risk for cardiovascular...

journal_title：European journal of pharmacology

authors： Osadchii OE

更新日期：2015-09-05 00:00:00

abstract：:Increased motor activity and poor performance in the active avoidance test were observed in the offspring of rats treated with dl-propranolol or sotalol during pregnancy, but not with atenolol and d-propranolol. All substances were administered in drinking water from days 8-22 of gestation. A significant increase in t...

journal_title：European journal of pharmacology

authors： Speiser Z,Gordon I,Rehavi M,Gitter S

更新日期：1991-03-19 00:00:00