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alpha-Methylnoradrenaline induced hypotension and bradycardia after administration into the area of the nucleus tractus solitarii.

Abstract：

:Bilateral injections of alpha-methylnoradrenaline into the area of the nucleus tractus solitarii of the brain stem caused a dose-dependent decrease of systemic arterial blood pressure and heart rate of anesthetized rats. The effects were prevented and even reversed by a preceding injection of the alpha-adrenoceptor blocking agent phentolamine. Pressor doses of angiotensin II and of arginine-vasopressin at the same site failed to drcrease blood pressure and heart rate.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Nijkamp FP,De Jong W

doi

10.1016/0014-2999(75)90305-2

keywords:

subject

Has Abstract

pub_date

1975-06-01 00:00:00

pages

361-4

issue

02

eissn

0014-2999

issn

1879-0712

pii

0014-2999(75)90305-2

journal_volume

32

pub_type

杂志文章

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