Evidence for separate Na+, K+, Cl- and K+, Cl- co-transport systems in mouse pancreatic beta-cells.

Abstract:

:The effects of H 25 and H 74 on ouabain-resistant 86Rb+ influx were tested in beta-cell-rich mouse pancreatic islets. Both H 25, which is considered to be a specific inhibitor of Na+, K+, Cl- co-transport, and H 74, a specific inhibitor of K+, Cl- co-transport, reduced the ouabain-resistant 86Rb+ influx. The specific inhibitory effects of H 25 and H 74 on 86Rb+ influx did not overlap. The data suggest that mouse pancreatic beta-cells are equipped with separate systems for Na+, K+, Cl- and K+, Cl- co-transport.

journal_name

Eur J Pharmacol

authors

Sandström PE,Sehlin J

doi

10.1016/0014-2999(93)90875-i

subject

Has Abstract

pub_date

1993-07-20 00:00:00

pages

403-5

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(93)90875-I

journal_volume

238

pub_type

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