Abstract:
:The effects of H 25 and H 74 on ouabain-resistant 86Rb+ influx were tested in beta-cell-rich mouse pancreatic islets. Both H 25, which is considered to be a specific inhibitor of Na+, K+, Cl- co-transport, and H 74, a specific inhibitor of K+, Cl- co-transport, reduced the ouabain-resistant 86Rb+ influx. The specific inhibitory effects of H 25 and H 74 on 86Rb+ influx did not overlap. The data suggest that mouse pancreatic beta-cells are equipped with separate systems for Na+, K+, Cl- and K+, Cl- co-transport.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Sandström PE,Sehlin Jdoi
10.1016/0014-2999(93)90875-isubject
Has Abstractpub_date
1993-07-20 00:00:00pages
403-5issue
2-3eissn
0014-2999issn
1879-0712pii
0014-2999(93)90875-Ijournal_volume
238pub_type
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