Abstract:
:The cardiac alpha1-adrenergic chronotropic response changes from stimulatory to inhibitory post-natally. The mature inhibitory response is mediated by the alpha1B-adrenoceptor and a pertussis toxin sensitive G protein. In vivo and in vitro studies identify sympathetic innervation as critical for the maturation of this inhibitory response. Additional experiments in a culture model indicate the effect of innervation is dependent on neurally released neuropeptide Y. The present study establishes that the individual signaling elements in the neuropeptide Y induced alpha1-adrenergic cascade are the same as those appearing during normal in vivo development. In addition, the data demonstrate that the effect of neuropeptide Y does not result from activation of the putative cardiac Y3 neuropeptide Y receptor subtype, since it is reproduced by the peptide fragment neuropeptide Y-(13-36) but not by [Leu31, Pro34]neuropeptide Y.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Sun LS,Rybin VO,Steinberg SF,Robinson RBdoi
10.1016/s0014-2999(98)00311-2subject
Has Abstractpub_date
1998-05-22 00:00:00pages
377-81issue
2-3eissn
0014-2999issn
1879-0712pii
S0014-2999(98)00311-2journal_volume
349pub_type
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