Effect of N,N-dimethyl-p-methoxyphenylethylamine on blood pressure and brain catecholamines in DOCA-saline hypertensive rats.

abstract：:It is increasingly recognized that most chronic diseases of concern today are multifactorial in origin. To combat such diseases and adverse health conditions, a treatment approach where medicines and nutrition complement each other may prove to be the most successful. Within nutrition, apart from (disease-related) die...

journal_title：European journal of pharmacology

authors： Eussen SR,Verhagen H,Klungel OH,Garssen J,van Loveren H,van Kranen HJ,Rompelberg CJ

更新日期：2011-09-01 00:00:00

abstract：:The effect of acute exposure to micromolar concentrations of kainic acid was studied in rat cerebellar astroglial cultures consisting of two antigenically and functionally distinct subpopulations of astrocytes. Kainate (20-100 microM) released [3H]GABA preaccumulated by A2B5-positive stellate astrocytes in a concentra...

journal_title：European journal of pharmacology

authors： Gallo V,Suergiu R,Levi G

更新日期：1986-12-16 00:00:00

abstract：:Genetic factors significantly contribute to the determination of human personality traits assessed by self-report questionnaires. However, only in the past few years have common genetic polymorphisms especially the dopamine D4 receptor and the serotonin transporter promoter region been associated with specific persona...

journal_title：European journal of pharmacology

authors： Ebstein RP,Benjamin J,Belmaker RH

更新日期：2000-12-27 00:00:00

abstract：:This article has been withdrawn at the request of the author(s). The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：European journal of pharmacology

authors： He Z,Chen C,Huang L,Liu S,Guo L

更新日期：2008-12-03 00:00:00

abstract：:Eosinophils and their granular proteins are crucial for combating allergic airway diseases. Eosinophils derived from HL-60 clone 15 (HC15) cells have been established as a feasible alternative cell model for human primary eosinophils. Simvastatin, a cholesterol-lowering agent, has been shown to exhibit anti-inflammato...

journal_title：European journal of pharmacology

authors： Fu CH,Lee TJ,Huang CC,Chang PH,Tsai JW,Chuang LP,Su Pang JH

更新日期：2019-08-05 00:00:00

abstract：:[14C]Guanidinium ion influx into Na+ channel preparations from mouse and rat cerebral cortex (purified synaptosomes, and synaptoneurosomes) was characterized and its properties were compared with those for 22Na+ influx. Tetrodotoxin-sensitive influx of [14C]guanidinium ion was stimulated by aconitine, veratridine, and...

journal_title：European journal of pharmacology

authors： Reith ME

更新日期：1990-01-23 00:00:00

abstract：:The aim of the present study was to correlate the impairment of cognitive function induced by scopolamine with the activity of dopaminergic synapses in brain areas which are innervated by the mesocortical limbic system (e.g. hippocampus and frontal cortex) or by the mesostriatal system (e.g. striatum and nucleus accum...

journal_title：European journal of pharmacology

authors： Memo M,Missale C,Trivelli L,Spano PF

更新日期：1988-05-10 00:00:00

abstract：:The present study investigated the effects of acute and of chronic treatment with desipramine (DI) and citalopram (CT) on the alterations in rat behavior in the open field and in the forced swim tests produced by intra-hippocampal microinjections of noradrenaline (NA) and adrenoceptor agonists. Chronic but not acute t...

journal_title：European journal of pharmacology

authors： Płaźnik A,Kostowski W

更新日期：1985-11-05 00:00:00

abstract：:Acute respiratory and metabolic acidosis as well as metabolic alkalosis increased (by 11, 11, 21%) whereas respiratory alkalosis antagonized (by 10%) the partial steady state block produced by pipecuronium infusion on the anterior tibialis muscle of the cat. The duration of neuromuscular block following six successive...

journal_title：European journal of pharmacology

authors： Biró K

更新日期：1988-09-23 00:00:00

abstract：:The present study addresses the causal relationship between induction of endo/sarcoplasmic reticulum stress and dysregulation of calcium transport, while examining whether the most widely-used experimental endo/sarcoplasmic reticulum stressors can be considered appropriate for elucidating underlying cellular mechanism...

journal_title：European journal of pharmacology

authors： Ziomek G,van Breemen C,Esfandiarei M

更新日期：2015-10-05 00:00:00

abstract：:High fat diet, as an important risk factor, plays a pivotal role in atherosclerotic process. Celastrol is one of the active triterpenoid compounds with antioxidative and anti-inflammatory characters. The aims of this study were to evaluate the effect of celastrol on weight, blood lipid and oxidative injury induced by ...

journal_title：European journal of pharmacology

authors： Wang C,Shi C,Yang X,Yang M,Sun H,Wang C

更新日期：2014-12-05 00:00:00

abstract：:The effects of three K+ channel openers on lysozyme output from submucosal gland serous cells and epithelial albumin transport following maintained submaximal stimulation by the secretagogues methacholine and phenylephrine were examined in the ferret trachea in vitro preparation. The K+ channel openers Ro 31-6930, 2-(...

journal_title：European journal of pharmacology

authors： Griffin A

更新日期：1995-07-14 00:00:00

abstract：:Several experiments were conducted to study the effects of established or potential antiparkinsonian drugs on the tremulous jaw movements induced by the anticholinesterase tacrine (9-amino-1,2,3,4-tetrahydroaminoacridine hydrochloride). In the first group of four experiments, separate groups of animals that received 2...

journal_title：European journal of pharmacology

authors： Cousins MS,Carriero DL,Salamone JD

更新日期：1997-03-19 00:00:00

abstract：:Effects of local anesthetics and structurally related drugs on the glibenclamide-sensitive K+ currents evoked by Y-26763 (a K+ channel opener) were investigated in native Xenopus oocytes. The K+ current induced by Y-26763 (100 microM) was reversibly suppressed by all six local anesthetics tested in a concentration-dep...

journal_title：European journal of pharmacology

authors： Yoneda I,Sakuta H,Okamoto K,Watanabe Y

更新日期：1993-11-15 00:00:00

abstract：:The effects of histamine H(1) receptor antagonists (promethazine, diphenhydramine, chlorphenilamine and triprolidine) on hippocampal theta rhythm during eight-arm radial maze performance were investigated using rats. Promethazine showed a significant increase in the number of total errors and working memory errors at ...

journal_title：European journal of pharmacology

authors： Masuoka T,Mikami A,Yasuda M,Shinomiya K,Kamei C

更新日期：2007-12-08 00:00:00

abstract：:Neurotensin is a neuropeptide associated with basal ganglia dopaminergic neurons. Because levels of neurotensin in striatal tissue are differentially affected by low or high doses of methamphetamine, we employed microdialysis to assess the dose-dependent effects of methamphetamine on neurotensin release from the termi...

journal_title：European journal of pharmacology

authors： Frankel PS,Hoonakker AJ,Hanson GR,Bush L,Keefe KA,Alburges ME

更新日期：2005-10-17 00:00:00

abstract：:The pharmacological activity of N-methyl-actinodaphnine, isolated from Illigera luzonensis, was determined by functional and binding experiments with peripheral tissues. In a functional study, N-methyl-actinodaphnine was a simple competitive antagonist of contractions elicited by phenylephrine (pA2 = 7.11) in rat thor...

journal_title：European journal of pharmacology

authors： Guh JH,Ko FN,Yu SM,Wu YC,Teng CM

更新日期：1995-06-06 00:00:00

abstract：:There is increasing evidence in support of an important role played by neurotensin (NT), a tridecapeptide originally found in bovine hypothalamus, in regulation of cardiovascular system. Elevated systemic levels of NT may contribute to pathogenesis of acute circulatory disoders, and predict the risk for cardiovascular...

journal_title：European journal of pharmacology

authors： Osadchii OE

更新日期：2015-09-05 00:00:00

abstract：:The benzodiazepine drugs modulate gamma-aminobutyric acid (GABA)-mediated synaptic transmission via a high-affinity binding site that is part of the GABA(A) receptor complex, but which is distinct from the GABA binding site. Ro15-4513 is a benzodiazepine negative modulator of GABA action that displays unique anti-etha...

journal_title：European journal of pharmacology

authors： Borden LA,Gibbs TT

更新日期：1990-06-12 00:00:00

abstract：:FACS analysis and [14C]-taurine efflux were used to determine whether activation of the volume-sensitive organic osmolyte/anion channel plays a role in cell cycle progression. This was achieved by examining the effects of a collection of (i) H(1) antagonists and tricyclic antidepressants with a known inhibitory effect...

journal_title：European journal of pharmacology

authors： Belsey MJ,Culliford SJ,Morley RM,Witchel HJ,Kozlowski RZ

更新日期：2003-08-08 00:00:00

abstract：:To investigate the effect of a single and multiple administration of lysergic acid diethylamide (LSD) on cerebral metabolism of dopamine and serotonin, male Wistar rats were treated with low and high doses (0.1 and 2.0 mg/kg i.p.) of LSD and the levels of dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, 3-...

journal_title：European journal of pharmacology

authors： Antkiewicz-Michaluk L,Románska I,Vetulani J

更新日期：1997-07-30 00:00:00

abstract：:The activity of the four glycoterpenoids: two saponins, verbascosaponin A and verbascosaponin, and two iridoids, scropolioside A and scrovalentinoside, isolated from Scrophularia auriculata ssp. pseudoauriculata, were studied in different models of acute and chronic inflammation. Both saponins significantly inhibited ...

journal_title：European journal of pharmacology

authors： Giner RM,Villalba ML,Recio MC,Máñez S,Cerdá-Nicolás M,Ríos J

更新日期：2000-02-18 00:00:00

abstract：:Dinitrosyl iron complexes (DNIC) with glutathione exert a cytotoxic effect on endometrioid tumours in rats with surgically induced experimental endometriosis. Intraperitoneal treatment of rats (Group 1) with DNIC (12.5μmoles/kg, daily, for 12 days), beginning with day 4 after the surgical operation (implantation of tw...

journal_title：European journal of pharmacology

authors： Burgova EN,Tkachev NА,Adamyan LV,Mikoyan VD,Paklina OV,Stepanyan AA,Vanin AF

更新日期：2014-03-15 00:00:00

abstract：:[N-methyl-Nle 28,31)]cholecystokinin-(26-33) (SNF 8702) is a highly selective ligand for the CCKB type of receptor present in the vertebrate central nervous system. Radioligand binding data showing that SNF 8702 binding affinity is reduced by the GTP analog guanylyl-imidodiphosphate suggest that SNF 8702 is an agonist...

journal_title：European journal of pharmacology

authors： Knapp RJ,Malatynska E,Peterson P,Zalewska T,Fang S,Hruby VJ,Smith TL,Yamamura HI

更新日期：1994-10-14 00:00:00

abstract：:In the present study, the emetic effect of the anticancer drug cisplatin, and the protective effects of 5-HT3 receptor antagonists against cisplatin emesis were investigated in the pigeon. The experimental set-up involved the i.v. administration of drugs and subsequent observation of the percentage of vomiting animals...

journal_title：European journal of pharmacology

authors： Preziosi P,D'Amato M,Del Carmine R,Martire M,Pozzoli G,Navarra P

更新日期：1992-10-20 00:00:00

abstract：:The putative imidazoline I(3) receptor antagonist 2-(2-ethyl-2,3-dihydrobenzo[b]furan-2-yl)-1H-imidazole (KU14R) has been shown to block the effects of the atypical I(3) agonist efaroxan at the level of the ATP-sensitive K(+) (K(ATP)) channel in isolated pancreatic islet beta cells, but its effects in vivo are not kno...

journal_title：European journal of pharmacology

authors： Mayer G,Taberner PV

更新日期：2002-11-01 00:00:00

abstract：:DNA methylation is considered as a potential cause of aberrations in regulation of gene expression during carcinogenesis. Therefore, changes in DNA methylation patterns may be targets for chemoprevention. In the present study, we investigated effects of all-trans retinoic acid (ATRA), vitamin D(3), and resveratrol alo...

journal_title：European journal of pharmacology

authors： Stefanska B,Rudnicka K,Bednarek A,Fabianowska-Majewska K

更新日期：2010-07-25 00:00:00

abstract：:We examined whether the proteinase-activated receptor-2 (PAR2) agonist, H-Ser-Leu-Ile-Gly-Arg-Leu-NH2 (SLIGRL-NH2), could induce scratching behavior in mice. Intradermal injections of SLIGRL-NH2 (10-50 microg) evoked dose dependent scratching. This behavior peaked near 5 min and returned to preinjection levels within ...

journal_title：European journal of pharmacology

authors： Shimada SG,Shimada KA,Collins JG

更新日期：2006-01-20 00:00:00

abstract：:The hypothesis that morphine acts on the serotonergic system to produce analgesia is based on the previous observations that (1) lesions and stimulation of midbrain raphe nuclei after the threshold to nociceptive stimuli; (2) morphine alters the turnover of serotonin (5-hydroxytryptamine; 5-HT). Microiontophoretic exp...

journal_title：European journal of pharmacology

authors： Haigler HJ

更新日期：1978-10-15 00:00:00

abstract：:Accumulating evidence indicates the role of microglial activation and sustained neuroinflammation in the pathogenesis of cognitive dysfunction, a common feature associated with depressive disorders. It also indicates the role of Wnt/β-catenin pathway in regulation of microglia-mediated neuroinflammation. Amisulpride e...

journal_title：European journal of pharmacology

authors： Mohamed AM,Habib MZ,Ebeid MA,Abdelraouf SM,El Faramawy Y,Aboul-Fotouh S,Magdy Y

更新日期：2020-10-15 00:00:00