The effects of 5-HT3 receptor antagonists on cisplatin-induced emesis in the pigeon.

abstract：:The insulin-like growth factor-1 receptor (IGF-1 receptor) is a receptor tyrosine kinase, highly homologous to the insulin receptor. In contrast to the insulin receptor, which is mostly involved in metabolic pathways, the IGF-1 system plays a pivotal role in normal and neoplastic cell growth through anti-apoptotic, pr...

journal_title：European journal of pharmacology

authors： Steiner L,Blum G,Friedmann Y,Levitzki A

更新日期：2007-05-07 00:00:00

abstract：:Diabetic osteopenia can result in an increased incidence of bone fracture and a delay in fracture healing. Quercetin, one of the most widely distributed flavonoids in plants, possesses antioxidant property and beneficial effect on osteoporosis in ovariectomized mice. All these properties make quercetin a potential can...

journal_title：European journal of pharmacology

authors： Liang W,Luo Z,Ge S,Li M,Du J,Yang M,Yan M,Ye Z,Luo Z

更新日期：2011-11-16 00:00:00

abstract：:Several contractile responses of longitudinal muscles of the guinea-pig digestive tract to exogenously applied ATP (10-300 micrometer), including "rebound" contractions, were inhibited by indomethacin (3-20 micrometer) or polyphloretin phosphate (10-100 microgram/ml). Relaxations to ATP in stomach and large intestina...

journal_title：European journal of pharmacology

authors： Kamikawa Y,Serizawa K,Shimo Y

更新日期：1977-09-15 00:00:00

abstract：:The present study was undertaken to determine the modulatory effects of nitric oxide (NO)-releasing compounds on increases in cytosolic ionized calcium ([Ca2+]i) and on aggregation of gel-filtered human platelets induced via diverse agonists. We used various sydnonimines and organic nitrates as donors of NO. Gel-filte...

journal_title：European journal of pharmacology

authors： Ivanova K,Schaefer M,Drummer C,Gerzer R

更新日期：1993-01-04 00:00:00

abstract：:The present study assessed 5-HT3 receptor recognition site levels in homogenates of putamen derived from patients with clinically and neurochemically diagnosed Huntington's disease or Parkinson's disease and those from age-, sex- and post-mortem delay-matched neurologically and psychiatrically normal patients to inves...

journal_title：European journal of pharmacology

authors： Steward LJ,Bufton KE,Hopkins PC,Davies WE,Barnes NM

更新日期：1993-09-28 00:00:00

abstract：:The tolerance to analgesia and dependence liability of dihydroetorphine following topical application were investigated in hairless rats with and without formalin-induced inflammation. The analgesic effect of dihydroetorphine (s.c.) was 4600- to 7200-fold more potent than that of morphine. In non-inflamed rats, the an...

journal_title：European journal of pharmacology

authors： Ohmori S,Fang L,Kawase M,Saito S,Morimoto Y

更新日期：2001-07-06 00:00:00

abstract：:The effects of inosine on sinus rate and atrial contractile force were investigated using the isolated and blood-perfused canine atrium which was perfused with arterial blood from a donor dog. Injected inosine (100-3000 micrograms) consistently induced positive chronotropic and inotropic effects. However, the larger d...

journal_title：European journal of pharmacology

authors： Furukawa Y,Chiba S

更新日期：1980-10-31 00:00:00

abstract：:MK-801, phenobarbital and clonazepam blocked convulsions elicited in mice by bicuculline. Treatment with Ro 15-1788 antagonized the anticonvulsant action of clonazepam, but not MK-801 or phenobarbital. The anticonflict effect in the rat of chlordiazepoxide, but not MK-801, was antagonized by Ro 15-1788. Despite having...

journal_title：European journal of pharmacology

authors： Clineschmidt BV

更新日期：1982-10-15 00:00:00

abstract：:The therapeutic potential of cannabidiol, the major non-psychotropic Cannabis constituent, was investigated in rats exposed to ischemia/reperfusion liver injury. Ischemia was induced by clamping the pedicle of the left hepatic lobe for 30 min, and cannabidiol (5mg/kg, i.v.) was given 1h following the procedure and eve...

journal_title：European journal of pharmacology

authors： Fouad AA,Jresat I

更新日期：2011-11-16 00:00:00

abstract：:The ligand preferences of recombinant NR1 homomeric and NR1-NR2 heteromeric NMDA receptors were examined by homogenate binding assay. The binding affinities for most ligands were similar to those reported for native NMDA receptors. The order of affinity for [3H]glutamate was NR1-NR2B > NR1-NR2A approximately NR1-NR2D ...

journal_title：European journal of pharmacology

authors： Laurie DJ,Seeburg PH

更新日期：1994-08-16 00:00:00

abstract：:The opioid properties of endomorphin derivatives containing a C-terminal alcoholic(-ol) function were compared to the parent amidated compounds in isolated organs (longitudinal muscle strip of guinea-pig ileum and mouse vas deferens). Similar data were also generated for the mu-opioid receptor selective agonist synthe...

journal_title：European journal of pharmacology

authors： Al-Khrasani M,Orosz G,Kocsis L,Farkas V,Magyar A,Lengyel I,Benyhe S,Borsodi A,Rónai AZ

更新日期：2001-06-01 00:00:00

abstract：:Activated microglia participate in neuroinflammation which contribute to neuronal damage. Suppression of microglial activation would have therapeutic benefits, which lead to alleviation of the progression of neurodegeneration. In this study, the inhibitory effects of inflexin, a putative antiinflammatory agent isolate...

journal_title：European journal of pharmacology

authors： Ko HM,Koppula S,Kim BW,Kim IS,Hwang BY,Suk K,Park EJ,Choi DK

更新日期：2010-05-10 00:00:00

abstract：:The actions of dequalinium have been investigated in cultured rat sympathetic neurones. It produced a rapid and reversible inhibition of the slow apamin-sensitive component of the afterhyperpolarization (AHP) which follows a single action potential in these cells. The IC50 for this effect was 1.1 microM and in voltage...

journal_title：European journal of pharmacology

authors： Dunn PM

更新日期：1994-02-03 00:00:00

abstract：:ICI 169,369 is a chemically novel 5-HT antagonist that has higher affinity for the 5-HT2 binding sites in rat cortex than it has for 5-HT1 sites (Ki 1.79 x 10(-8) and 1.58 x 10(-6) M, respectively). In isolated tissue preparations ICI 169,369 was shown to be a competitive antagonist of 5-HT on the rabbit aorta, pig co...

journal_title：European journal of pharmacology

authors： Blackburn TP,Thornber CW,Pearce RJ,Cox B

更新日期：1988-06-10 00:00:00

abstract：:The effects of (-)-(R)-2-methyl-3-(1-pyrrolidinyl)-4'- trifluoromethylpropiophenone monohydrochloride (NK433), a novel centrally acting muscle relaxant, on masticatory muscle reflexes were investigated in rats. NK433 inhibited the monosynaptic tonic vibration reflex of the masseter muscle and the polysynaptic tonic pe...

journal_title：European journal of pharmacology

authors： Ozawa Y,Komai C,Sakitama K,Ishikawa M

更新日期：1996-02-29 00:00:00

abstract：:CPP, administered systemically, elicited four distinct responses characteristic of serotonin-receptor activation in the central nervous system. The crossed extensor reflex in the acutely spinalized rat was enhanced by treatment with CPP, 1-16 mg/kg. CPP, 1.11-10 mg/kg, elicited a dose-related increase in head twitches...

journal_title：European journal of pharmacology

authors： Clineschmidt BV,Mcguffin JC,Pflueger AB

更新日期：1977-07-01 00:00:00

abstract：:The pharmacology of neurogenic trigeminovascular vasodilator responses in the dura mater is of interest for understanding the pathophysiology of migraine and to develop new therapies for this disabling common condition. Aminergic mechanisms have been implicated in migraine through direct study of amines in patients, a...

journal_title：European journal of pharmacology

authors： Akerman S,Williamson DJ,Hill RG,Goadsby PJ

更新日期：2001-07-13 00:00:00

abstract：:Nicotine is one of the most representative components in cigarette smoke leading to gastric ulceration. Both ornithine decarboxylase and potassium ion (K(+)) channels are essential for cell growth and wound repair. The aim of the present study is to elucidate the causative relationship of these two factors during woun...

journal_title：European journal of pharmacology

authors： Shin VY,Liu ES,Koo MW,Luo JC,So WH,Cho CH

更新日期：2002-05-24 00:00:00

abstract：:Three non-steroidal antiinflammatory agents were tested for their ability to antagonize bradykinin in the rabbit jugular vein, the dog carotid artery and the guinea pig trachea. The new agents were compared with indomethacin, as well as with [Thi5,8,D-Phe7] bradykinin and [Thi6,9,D-Phe8] kallidin, two B2 receptor anta...

journal_title：European journal of pharmacology

authors： Rhaleb NE,Dion S,D'Orléans-Juste P,Drapeau G,Regoli D,Browne RG

更新日期：1988-07-07 00:00:00

abstract：:Previous results indicated that the rabbit could represent a suitable model for investigations on the functional role of alpha 2-adrenoceptors in fat cells, but the characterization of these receptors was not resolved yet. In the present report, imidazoline compounds were used to attempt a better definition of rabbit ...

journal_title：European journal of pharmacology

authors： Langin D,Paris H,Dauzats M,Lafontan M

更新日期：1990-04-25 00:00:00

abstract：:The antagonist effects of ketanserin and 2'-methyl-4'-(5-methyl-1,2,4)oxadiazol-3-yl)-biphenyl-[4-carboxyli c acid 4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide (GR 127,935) were compared to naratriptan-induced inhibition of cAMP formation in C6-glial cell lines stably expressing human 5-HT1D or 5-HT1B receptor ...

journal_title：European journal of pharmacology

authors： Pauwels PJ,Colpaert FC

更新日期：1996-04-04 00:00:00

abstract：:Calcitonin can selectively modulate the effects of opioids on the rat hypothalamic-pituitary-adrenal axis and increase the release of corticosterone induced by a kappa-opioid receptor agonist. Considerable evidence supports the involvement of opioid and serotonergic systems in the analgesic effect of calcitonin. In th...

journal_title：European journal of pharmacology

authors： Ormazábal MJ,Milanés MV,Martín MI

更新日期：1997-12-04 00:00:00

abstract：:Immunocytochemical and Co(2+) uptake studies revealed that in primary cultures of rat cortical neurones, the majority of neurones are gamma-aminobutyric acid (GABA) immunopositive and can express Ca(2+)-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors. By fura-2 microfluorimetry, it...

journal_title：European journal of pharmacology

authors： Fischer W,Franke H,Scheibler P,Allgaier C,Illes P

更新日期：2002-03-01 00:00:00

abstract：:The arteriovenous fistula model of circulation can produce a high output and low peripheral resistance situation. Here, we have examined the effects of noradrenaline, vasopressin and sodium nitroprusside on cardiac index, mean arterial blood pressure, venous tone, resistance to venous return, arterial resistance, and ...

journal_title：European journal of pharmacology

authors： Guo L,Tabrizchi R

更新日期：2008-05-31 00:00:00

abstract：:Ouabain- and bumetanide-resistant potassium fluxes were measured in human erythrocytes incubated in a medium containing calcium and a calcium ionophore. Pharmacological concentrations of rat atrial natriuretic peptide stimulated these fluxes. Although human erythrocytes lack atrial natriuretic peptide receptors, our r...

journal_title：European journal of pharmacology

authors： Esparza N,Díez J

更新日期：1989-07-18 00:00:00

abstract：:We investigated the relationship between tension development and the cytosolic free Ca2+ level ([Ca2+]i) on exposure of the endothelium-denuded isolated rat aorta to palmitoyl-L-alpha-lysophosphatidylcholine. Lysophosphatidylcholine concentration-dependently induced a gradual increase in [Ca2+]i. Application of 10(-4)...

journal_title：European journal of pharmacology

authors： Suenaga H,Kamata K

更新日期：1999-08-06 00:00:00

abstract：:We have investigated the cardiac and pressor responses to (±)-ephedrine and (-)-ephedrine in pentobarbitone anaesthetized male wistar rats. The tachycardiac responses to (±)- and (-)-ephedrine were similar, but pressor responses to (-)-ephedrine (10 mg/kg) were significantly greater than those to (±)-ephedrine, and fo...

journal_title：European journal of pharmacology

authors： Alsufyani HA,Docherty JR

更新日期：2018-04-15 00:00:00

abstract：:The molecular mechanism underlying the activity of the novel antiepileptic drug retigabine is not yet fully understood. The aim of this study was to investigate whether retigabine interacts directly with the GABA(A) receptor complex (gamma-aminobutyric acid). Receptor-binding assays were conducted using rat brain memb...

journal_title：European journal of pharmacology

authors： van Rijn CM,Willems-van Bree E

更新日期：2003-03-19 00:00:00

abstract：:Inhibition of local cortisol regeneration from circulating cortisone by blocking 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) has been shown to ameliorate the risk factors associated with the metabolic syndrome. Chronic modulation of glucocorticoid homeostasis may result in hypothalamic-pituitary-adrenal (HPA) axis s...

journal_title：European journal of pharmacology

authors： Hamilton BS,Schoelch C,Schuler-Metz A,Krosky P,Lala DS,Claremon DA,McGeehan GM

更新日期：2016-10-15 00:00:00

abstract：:The effects of capsaicin pretreatment on withdrawal responses of guinea-pig isolated ileum to [Met5]enkephalin (ME) and morphine and on the locomotor withdrawal response of guinea-pigs following a single dose of morphine, were investigated. In vitro treatment of ileum with capsaicin, 1.5 mumol/l for 1 h, did not signi...

journal_title：European journal of pharmacology

authors： Chahl LA

更新日期：1988-12-06 00:00:00