Some possibilities for prostaglandin mediation in the contractile response to ATP of the guinea-pig digestive tract.

abstract：:The antagonist effects of ketanserin and 2'-methyl-4'-(5-methyl-1,2,4)oxadiazol-3-yl)-biphenyl-[4-carboxyli c acid 4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide (GR 127,935) were compared to naratriptan-induced inhibition of cAMP formation in C6-glial cell lines stably expressing human 5-HT1D or 5-HT1B receptor ...

journal_title：European journal of pharmacology

authors： Pauwels PJ,Colpaert FC

更新日期：1996-04-04 00:00:00

abstract：:The effects of ketamine on the cholinergic excitatory and inhibitory (Cl component) responses in Aplysia neurons were examined using the iontophoretic application of ACh and the two-microelectrode voltage clamp technique. Ketamine reduced both responses non-competitively to the same extent in a dose-dependent and reve...

journal_title：European journal of pharmacology

authors： Ikemoto Y

更新日期：1986-12-02 00:00:00

abstract：:Pedigreed inbred lines of pigmented mice were compared with albino lines differing at either a single locus or by a chromosomal segment of interest, for their responses to morphine. In either of two tests, behavioral activation or reduction in core temperature, albino mice were aberrant in their responses, demonstrati...

journal_title：European journal of pharmacology

authors： Katz RJ

更新日期：1980-11-21 00:00:00

abstract：:Huperzine A, a promising therapeutic agent for Alzheimer's disease, was examined for its potential to antagonize the deleterious neurochemical, structural, and cognitive effects of infusing beta-amyloid protein-(1-40) into the cerebral ventricles of rats. Daily intraperitoneal administration of huperzine A for 12 cons...

journal_title：European journal of pharmacology

authors： Wang R,Zhang HY,Tang XC

更新日期：2001-06-15 00:00:00

abstract：:SR 57746A, 4-(3-trifluoromethylphenyl)-N-[2-(naphth-2-yl)ethyl]-1,2,3,6- tetrahydropyridine HCl, was studied for its specific 5-HT1A receptor agonist action and antidepressant-like effects in the rat. The compound showed a high affinity for 5-HT1A specific binding sites in the rat hippocampus (IC50 3 nM), moderate aff...

journal_title：European journal of pharmacology

authors： Cervo L,Bendotti C,Tarizzo G,Cagnotto A,Skorupska M,Mennini T,Samanin R

更新日期：1994-02-21 00:00:00

abstract：:Molecular identification of two new transient receptor potential (TRP) channels, TRPM8 and TRPA1, has prompted an intense interest in their functional roles. We report that an acute exposure to the TRPM8/TRPA1 agonist icilin (0.01-100 microM), but not TRPV1 agonist capsaicin (10 microM), causes an atypical dose-relate...

journal_title：European journal of pharmacology

authors： Rawls SM,Gomez T,Ding Z,Raffa RB

更新日期：2007-12-01 00:00:00

abstract：:The role of substance P in the cerebral parenchymal circulation was examined in 19 anesthetized cats. The local cerebral blood volume in the temporoparietal cortex was measured by our photoelectric method. Cerebral blood volume reflects the cumulative dimensions of the parenchymal microvessels. Intravenous injection o...

journal_title：European journal of pharmacology

authors： Kobari M,Tomita M,Tanahashi N,Yokoyama M,Takao M,Fukuuchi Y

更新日期：1996-12-19 00:00:00

abstract：:The cellular localisation and distribution of mRNAs encoding beta-adrenoceptor subtypes in human lung were studied by in situ hybridisation and Northern blot analysis. The 851-bp SmaI/PvuII fragment of human beta 1-adrenoceptor cDNA, the 439-bp SmaI fragment of human beta 2-adrenoceptor cDNA and the 975-bp SmaI fragme...

journal_title：European journal of pharmacology

authors： Mak JC,Nishikawa M,Haddad EB,Kwon OJ,Hirst SJ,Twort CH,Barnes PJ

更新日期：1996-04-29 00:00:00

abstract：:Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a rare monogenic idiopathic partial epilepsy characterized by clusters of frontal lobe motor seizures during sleep. Recently, it has been shown that mutations of the chromosome-20q-located neuronal nicotinic acetylcholine receptor alpha4-subunit (CHRNA4) a...

journal_title：European journal of pharmacology

authors： Steinlein OK

更新日期：2000-03-30 00:00:00

abstract：:The electrodermal potential (EDP) recorded in the forepaws of anaesthetized cats in response to stimulation of the cholinergic-sympathetic nervous system at different levels was taken as a measure for sudomotor activity. Electrical stimulation of the hypothalamus with square wave pulses (1 ms duration, 0.5-64 Hz, 2 s ...

journal_title：European journal of pharmacology

authors： Rybarczyk MC,Walland A

更新日期：1985-06-19 00:00:00

abstract：:There is evidence that the septohippocampal cholinergic system is activated in response to stressful stimuli. In addition, prior studies indicate that stimulating the hippocampal cholinergic neurotransmission increases open arm exploration in the elevated plus-maze. This raises the possibility that exposing the rat to...

journal_title：European journal of pharmacology

authors： Degroot A,Wade M,Salhoff C,Davis RJ,Tzavara ET,Nomikos GG

更新日期：2004-06-16 00:00:00

abstract：:Diabetic osteopenia can result in an increased incidence of bone fracture and a delay in fracture healing. Quercetin, one of the most widely distributed flavonoids in plants, possesses antioxidant property and beneficial effect on osteoporosis in ovariectomized mice. All these properties make quercetin a potential can...

journal_title：European journal of pharmacology

authors： Liang W,Luo Z,Ge S,Li M,Du J,Yang M,Yan M,Ye Z,Luo Z

更新日期：2011-11-16 00:00:00

abstract：:Brain microvessel endothelial cell monolayers have been shown to be a suitable blood-brain barrier in vitro system to study adrenergic regulation of permeability. We tested adrenergic drugs on bovine brain microvessel endothelial cell monolayer permeability to a biomembrane impermeant molecule, sodium fluorescein. End...

journal_title：European journal of pharmacology

authors： Borges N,Shi F,Azevedo I,Audus KL

更新日期：1994-10-14 00:00:00

abstract：:A specific protein kinase C inhibitor, calphostin C, which injected alone had no effect on the antinociception induced by intrathecal (i.t.) administration of a selective mu-opioid receptor agonist, [D-Ala2,NMePhe4,Gly(ol)5]enkephalin (DAMGO), dose-dependently attenuated the development of acute tolerance to the i.t. ...

journal_title：European journal of pharmacology

authors： Narita M,Narita M,Mizoguchi H,Tseng LF

更新日期：1995-07-04 00:00:00

abstract：:In pregnant rat myometrium, isoproterenol (10(-8) M) inhibited spontaneous contractions without causing hyperpolarization. Isoproterenol (10(-6) M) relaxed the depolarized muscle without affecting the membrane potential. The presence of 80 mM Na+ did not affect the degree of high-K+ depolarization. It was also without...

journal_title：European journal of pharmacology

authors： Meisheri KD,McNeill JH,Marshall JM

更新日期：1979-11-23 00:00:00

abstract：:Gender-related differences in susceptibility to stress and stress-related disorders such as depression, and in response to treatment with antidepressants have been observed, but the underlying molecular mechanisms are still unknown. Considering the role of glucocorticoid hormones in the systemic reaction against stres...

journal_title：European journal of pharmacology

authors： Elaković I,Brkljacić J,Matić G

更新日期：2009-04-17 00:00:00

abstract：:Clozapine has improved efficacy relative to typical antipsychotics in schizophrenia treatment, particularly regarding emotional symptoms. However, the mechanisms underlying its therapeutic benefits remain unclear. Using a methamphetamine-sensitised rat model, we measured changes in dopamine levels in the amygdalae in ...

journal_title：European journal of pharmacology

authors： Kawano M,Oshibuchi H,Kawano T,Muraoka H,Tsutsumi T,Yamada M,Inada K,Ishigooka J

更新日期：2016-06-15 00:00:00

abstract：:In conscious rats, intracerebroventricular (i.c.v.) treatment with the GABA agonist muscimol (1-100 ng) suppressed the pressor responses to ANG II (100 ng i.c.v.) in a dose-dependent and reversible fashion. Treatment i.c.v. with GABA (1-500 micrograms) produced a similar but shorter inhibition. Inhibition of endogenou...

journal_title：European journal of pharmacology

authors： Unger T,Bles F,Ganten D,Lang RE,Rettig R,Schwab NA

更新日期：1983-05-20 00:00:00

abstract：:The overactivation of glutamate receptors is a major cause of Ca(2+) overload in cells, potentially leading to cell damage and death. There is an abundance of agents and mechanisms by which glutamate receptor activation can be prevented or modulated in order to control these effects. They include the well-established,...

journal_title：European journal of pharmacology

authors： Stone TW,Addae JI

更新日期：2002-07-05 00:00:00

abstract：:The affinity of LY-171555 (quinpirole) and BHT-920 for both states of rat striatal dopamine D-1 and D-2 receptors was determined. Although these drugs have different pharmacological effects in experimental animals, we found that they had similar affinities for both D-1 and D-2 receptors. ...

journal_title：European journal of pharmacology

authors： Ferré S,Guix T,Sallés J,Cuffí L,Badia A,Casas M

更新日期：1989-07-18 00:00:00

abstract：:The aim of the study was to determine the influence of N-(ortho-carboxyanilinomethyl)-p-isopropoxyphenylsuccinimide [o-CAMIPPS], N-(meta-carboxyanilinomethyl)-p-isopropoxyphenylsuccinimide [m-CAMIPPS], and N-(para-carboxyanilinomethyl)-p-isopropoxyphenylsuccinimide [p-CAMIPPS] on the protective activity of four classi...

journal_title：European journal of pharmacology

authors： Luszczki JJ,Cioczek JD,Kocharov SL,Andres-Mach M,Kominek M,Zolkowska D

更新日期：2010-12-01 00:00:00

abstract：:Lergotrile and apomorphine, two direct-acting dopamine agonists, caused marked hyperglycemia in fasted rats, while compounds which release endogenous dopamine (amphetamine, methylphenidate) or inhibit dopamine reuptake (LR5182), failed to elevate blood glucose. The effect of lergotrile was dose dependent, causing bloo...

journal_title：European journal of pharmacology

authors： Schmidt MJ

更新日期：1979-10-26 00:00:00

abstract：:GABA regulates the binding of [35S]t-butylbicyclophosphorothionate ([35S]TBPS) within the GABA receptor-ionophore complex by decreasing the rate of radioligand association and increasing the rate of dissociation but in different ways for the EDTA/water-dialyzed rat brain membranes and a solubilized preparation obtaine...

journal_title：European journal of pharmacology

authors： Seifert J,Casida JE

更新日期：1985-09-24 00:00:00

abstract：:We investigated the effects of 1-amino-5-bromouracil on the benzodiazepine-gamma-aminobutyric acid (GABA)A receptor complex to elucidate its central action. 1-Amino-5-bromouracil neither displaced nor enhanced [3H]muscimol, [35S]t-butylbicyclophosphorothionate (TBPS), or [3H]dehydroepiandrosterone sulfate binding to t...

journal_title：European journal of pharmacology

authors： Miyazaki S,Imaizumi M,Machida H

更新日期：1994-12-12 00:00:00

abstract：:We investigated the effects of 7-nitroindazole, a specific inhibitor of neuronal nitric oxide (NO) synthase, on NO concentration and on blood flow in rat hippocampus after transient forebrain ischemia which was induced by 4-vessel occlusion for 10 min. NO concentration was measured directly by an NO-selective electrod...

journal_title：European journal of pharmacology

authors： Jiang MH,Kaku T,Hada J,Hayashi Y

更新日期：1999-09-10 00:00:00

abstract：:The maximal pressor effect induced by DOI in the pithed rat was smaller than that induced by 5-HT, suggesting partial agonistic properties of DOI. DOI shifted the dose-pressor response curve of 5-HT to the right. It is concluded that, in addition to its 5-HT2 agonistic properties, DOI also possesses 5-HT2 antagonistic...

journal_title：European journal of pharmacology

authors： Dabiré H,Chaouche-Teyara K,Cherqui C,Fournier B,Schmitt H

更新日期：1989-10-24 00:00:00

abstract：:Sabiporide, a new benzoguanidine, was characterized on fibroblasts stably expressing the Na(+)/H(+) exchanger isoforms NHE-1, NHE-2 and NHE-3. 22Na(+) uptake experiments show that this compound possesses a K(i) of 5+/-1.2 x 10(-8) M for NHE-1, and discriminates efficiently between the NHE-1, -2 and -3 isoforms (K(i) f...

journal_title：European journal of pharmacology

authors： Touret N,Tanneur V,Godart H,Seidler R,Taki N,Bürger E,Dämmgen J,Counillon L

更新日期：2003-01-17 00:00:00

abstract：:We have made extracellular recordings from locus coeruleus neurones contained in a pontine slice preparation. The in vitro technique permits application of known concentrations of drugs in the perfusion medium. Substance P excites locus coeruleus neurones in a concentration-dependent manner. The activity of substance ...

journal_title：European journal of pharmacology

authors： Cheeseman HJ,Pinnock RD,Henderson G

更新日期：1983-10-14 00:00:00

abstract：:Unexpectedly, it was observed that the P2-purinoceptor antagonist, suramin (10 microM to 1 mM), reversed the muscle paralysis caused by structurally unrelated non-depolarizing relaxants. Suramin competitively reversed the blocking action of pancuronium. Both the pre- and postsynaptic blockade of nicotinic receptors by...

journal_title：European journal of pharmacology

authors： Henning RH,Nelemans A,Scaf AH,Van Eekeren J,Agoston S,Den Hertog A

更新日期：1992-05-27 00:00:00

abstract：:Several selective phosphodiesterase 4 inhibitors were found to be potent inhibitors of the N-formyl-Met-Leu-Phe (fMLP)-induced leukotriene B4 biosynthesis by human polymorphonuclear leukocytes with IC50s in the nanomolar range (0.09-26 nM). The rank order of potency was 6-(4-pyridylmethyl)-8-(3-nitrophenyl)quinoline (...

journal_title：European journal of pharmacology

authors： Denis D,Riendeau D

更新日期：1999-02-19 00:00:00