Differential behavioral effect of the TRPM8/TRPA1 channel agonist icilin (AG-3-5).

abstract：:Free radicals may cause part of the irreversible injury which occurs during myocardial infarction and reperfusion. In the present study MDL 73404, an alpha-tocopherol analogue which is a free radical scavenger has been evaluated for its effects on infarct size in an anaesthetised rat model of coronary artery ligation ...

journal_title：European journal of pharmacology

authors： Petty MA,Grisar JM,De Jong W

更新日期：1992-01-07 00:00:00

abstract：:The binding of tritium-labelled BIBP3226, N2-(diphenylacetyl)-N-[(4-hydroxy-phenyl)methyl]-D-arginine amide, to human neuroblastoma SK-N-MC cells was investigated. [3H]BIBP3226 reversibly binds to neuropeptide Y receptors of the Y1 subtype expressed in SK-N-MC cells with a KD of 2.1 +/- 0.3 nM (mean +/- S.E.M., n = 3)...

journal_title：European journal of pharmacology

authors： Entzeroth M,Braunger H,Eberlein W,Engel W,Rudolf K,Wienen W,Wieland HA,Willim KD,Doods HN

更新日期：1995-05-24 00:00:00

abstract：:We previously reported that both nitric oxide (NO) generated from NO synthase by bombesin and NO generated from SIN-1 (NO donor) activate the brain cyclooxygenase (COX) (COX-1 for bombesin), thereby eliciting the secretion of both catecholamines (CA) from the adrenal medulla by brain thromboxane A(2)-mediated mechanis...

journal_title：European journal of pharmacology

authors： Tanaka K,Shimizu T,Lu L,Yokotani K

更新日期：2012-03-15 00:00:00

abstract：:Increasing stimulation frequency and monensin were utilized in attempts to enhance Na+ influx and thereby elicit the maximum rate of ouabain-sensitive 86Rb+ uptake in rat atrial muscle. Increasing stimulation frequency between 0 and 9 Hz enhanced the rate of ouabain-sensitive 86Rb+ uptake, whereas the uptake rate appe...

journal_title：European journal of pharmacology

authors： Kennedy RH,Seifen E,Kafiluddi R

更新日期：1986-09-23 00:00:00

abstract：:Glutamine is the most abundant amino acid in the bloodstream. It is important in nucleotide synthesis, is anti-catabolic, has anti-oxidant properties via metabolism to glutathione, may enhance immune responsiveness and possesses immunoregulatory functions. Moreover, it reduces atrophy of intestinal mucosa in animals o...

journal_title：European journal of pharmacology

authors： Mondello S,Galuppo M,Mazzon E,Italiano D,Mondello P,Aloisi C,Cuzzocrea S

更新日期：2011-05-01 00:00:00

abstract：:The effects of systemic administration of the full dopamine D1 receptor agonist A-77636 on acetylcholine release in rat frontal cortex and hippocampus were studied using in vivo microdialysis. Administration of A-77636 (4 mumol/kg s.c.) greatly (> 230%) increased both cortical and hippocampal acetylcholine release for...

journal_title：European journal of pharmacology

authors： Acquas E,Day JC,Fibiger HC

更新日期：1994-07-21 00:00:00

abstract：:Desensitization of serotonin 5-HT2 receptor-mediated enhancement of the N-methyl-D-aspartate (NMDA) depolarization was studied in rat cortical neurons. Serotonin and (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) induced long term desensitization. Staurosporine, a nonspecific protein kinase C inhibitor, pot...

journal_title：European journal of pharmacology

authors： Rahman S,Neuman RS

更新日期：1993-07-20 00:00:00

abstract：:The molecular mechanisms regulating the trafficking of the CRTH2 receptor are poorly understood. In the present study, we characterize C-terminal tail determinants involved in the agonist-induced trafficking of the CRTH2 receptor for prostaglandin D(2). Our results showed that progressive deletion of C-terminal tail r...

journal_title：European journal of pharmacology

authors： Roy SJ,Parent A,Gallant MA,de Brum-Fernandes AJ,Stanková J,Parent JL

更新日期：2010-03-25 00:00:00

abstract：:Behavioral and biochemical techniques were used to compare the in vivo intrinsic efficacy of two new 2-(4-aminophenyl)-N, N-dipropylethylamine dopamine D(2) receptor agonists, 2-(4-amino-3-trifluoromethylphenyl)-N-N-dipropyl-ethylamine (NBF-203) and 2-(4-amino-3-bromo-5-trifluoromethylphenyl)-N-N-dipropylethylamine (N...

journal_title：European journal of pharmacology

authors： Ahlenius S,Ericson E,Florvall L,Jiménez P,Hillegaart V,Wijkström A

更新日期：2000-04-14 00:00:00

abstract：:This study shows that in spontaneously hypertensive rats (SHR) of 14-weeks-old, the sympathetically-induced, but not noradrenaline-induced tachycardic response are higher than age-matched Wistar normotensive rats. Furthermore, in SHR the sympathetically-induced tachycardic response was: (1) unaffected by moxonidine (3...

journal_title：European journal of pharmacology

authors： Cobos-Puc LE,Sánchez-López A,Centurión D

更新日期：2016-11-15 00:00:00

abstract：:The action of antidepressants on cell proliferation (bromodeoxyuridine (BrdU) or [3H]thymidine incorporation) was studied in the adult rat hippocampus in vivo and in neural precursors (immature rat cerebellar granule cells) in vitro. In vivo, prolonged (21 days) but not acute (single) intraperitoneal treatment with fl...

journal_title：European journal of pharmacology

authors： Manev H,Uz T,Smalheiser NR,Manev R

更新日期：2001-01-05 00:00:00

abstract：:In rats, tolerance to the analgesic effect of intraventricular substance P (SP) develops quickly. In rats made tolerant to [D-Ala2, D-Leu5]enkephalin the analgesic efficacy of SP is reduced significantly. The latter result suggests some overlap in the sites of action of SP and [D-Ala2,D-Leu5] enkephalin. Since SP seem...

journal_title：European journal of pharmacology

authors： Naranjo JR,Fernandez-Tome MP,Del Rio J

更新日期：1984-02-10 00:00:00

abstract：:Ovarian cancer is the major cause of cancer death among female genital malignancies, and requires developing novel therapeutic measures. Immune escape and acquisition of tolerance by tumor cells are essential for cancer growth and progression. An immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) overexpression...

journal_title：European journal of pharmacology

authors： Kobayashi A,Tanizaki Y,Kimura A,Ishida Y,Nosaka M,Toujima S,Kuninaka Y,Minami S,Ino K,Kondo T

更新日期：2015-11-05 00:00:00

abstract：:The autoradiographic distribution of putative brain adrenomedullin receptors was investigated using [125I]human adrenomedullin(13-52) as a new radioligand. Specific [125I]human adrenomedullin(13-52) binding sites were very discretely distributed in the rat brain with enrichment seen in the choroid plexus and linings o...

journal_title：European journal of pharmacology

authors： Juaneda C,Dumont Y,Chabot JG,Quirion R

更新日期：2001-06-08 00:00:00

abstract：:Nuclear factor-kappaB (NF-kappaB) is a critical regulator of many genes involved in the pathogenesis of bacterial meningitis. Recently, activation of NF-kappaB was shown to be a key event in the inflammatory host response and the development of intracranial complications during experimental pneumococcal meningitis. Si...

journal_title：European journal of pharmacology

authors： Kastenbauer S,Koedel U,Weih F,Ziegler-Heitbrock L,Pfister HW

更新日期：2004-09-13 00:00:00

abstract：:The significance of the blood pressure elevation caused by N(G)-nitro-L-arginine (L-NNA) to inhibitory mechanism of the drug on depressor responses to acetylcholine in anesthetized dogs was investigated. L-NNA (50 mg kg(-1), i.v.) elevated blood pressure to a plateau of 30-50 mm Hg above baseline level and shifted the...

journal_title：European journal of pharmacology

authors： Nakahara T,Nejishima H,Nakayama K,Ishii K

更新日期：1999-06-04 00:00:00

abstract：:Horizontal motor activity, rearing and head dipping were recorded automatically in rats placed on a holeboard and taken as indices of locomotion and exploration. Other behaviours were assessed visually using a video camera. SKF 38393, 15-30 mg/kg (D-1 agonist), suppressed all three behavioural measures more effectivel...

journal_title：European journal of pharmacology

authors： Fletcher GH,Starr MS

更新日期：1985-11-19 00:00:00

abstract：:Synaptosomal membranes from cat cerebral cortex were labelled with [3H]-quinuclidinyl benzylate ([3H]QNB). There was shown to be a single type of binding site with Kd = 0.34 nM, Bmax = 2.2 nmol/g protein and Hill No. = 1.01. Triton X-100 at 5 x 10(-4)% inhibited the specific binding of [3H]QNB and the inhibition was a...

journal_title：European journal of pharmacology

authors： Aguilar JS,Criado M,De Robertis E

更新日期：1980-05-16 00:00:00

abstract：:The effect of GABA (gamma-aminobutyric acid system) receptor agonists and antagonists on naloxone-induced jumping in morphine-dependent mice was examined. Intraperitoneal (i.p.) or intracerebroventricular (i.c.v.) injection of different doses of the GABA(B) receptor agonist, baclofen (2.5, 5 and 10 mg/kg), reduced nal...

journal_title：European journal of pharmacology

authors： Zarrindast MR,Mousa-Ahmadi E

更新日期：1999-09-24 00:00:00

abstract：:Avid Na+ retention is a hallmark of liver cirrhosis. The aim of this study was to investigate whether and how bradykinin is involved in Na+ retention in rats with CCl4-induced liver cirrhosis. To this end the bradykinin B2 receptor antagonist Icatibant (HOE 140) was used. On one hand, bradykinin has a renal natriureti...

journal_title：European journal of pharmacology

authors： Wirth KJ,Bickel M,Hropot M,Günzler V,Heitsch H,Ruppert D,Schölkens BA

更新日期：1997-10-15 00:00:00

abstract：:GABA regulates the binding of [35S]t-butylbicyclophosphorothionate ([35S]TBPS) within the GABA receptor-ionophore complex by decreasing the rate of radioligand association and increasing the rate of dissociation but in different ways for the EDTA/water-dialyzed rat brain membranes and a solubilized preparation obtaine...

journal_title：European journal of pharmacology

authors： Seifert J,Casida JE

更新日期：1985-09-24 00:00:00

abstract：:Deferoxamine has shown cutaneous wound healing potential by increased neovascularization. We hypothesized that topically applied deferoxamine facilitates wound healing in diabetic rats by modulating important cytokines and growth factors that take part in healing processes in a time-dependent manner. Diabetes was indu...

journal_title：European journal of pharmacology

authors： Ram M,Singh V,Kumawat S,Kumar D,Lingaraju MC,Uttam Singh T,Rahal A,Kumar Tandan S,Kumar D

更新日期：2015-10-05 00:00:00

abstract：:Carbachol produces both negative and positive inotropy in rat left atria. It is not clear whether these two effects are mediated by two separate cell surface muscarinic receptors or a single receptor interacting with two coupling proteins in the cell membrane. Pirenzepine, known to selectively block some biochemical m...

journal_title：European journal of pharmacology

authors： Boselli C,Kenakin TP

更新日期：1990-11-20 00:00:00

abstract：:In a recent study we have shown that it was possible to recognize and record two independent behavioural patterns elicited by apomorphine (s.c.): one behaviour characterized by increased locomotion, sniffing and repetitive head and limb movements and another, characterized by compulsive gnawing. In the present study w...

journal_title：European journal of pharmacology

authors： Ljungberg T,Ungerstedt U

更新日期：1977-11-15 00:00:00

abstract：:The present study investigated the mechanisms involved in the antinociception produced by the triterpene 3β, 6β, 16β-trihydroxylup-20(29)-ene (TTHL) in mice. TTHL administered by intra-gastric (i.g.) gavage inhibited glutamate-induced nociception with an ID(50) of 19.0 (13.2-27.5) mg/kg. This action started 60 min (in...

journal_title：European journal of pharmacology

authors： Longhi-Balbinot DT,Martins DF,Lanznaster D,Silva MD,Facundo VA,Santos AR

更新日期：2011-02-25 00:00:00

abstract：:Three naturally occurring peptides, pGlu-Glu-Pro amide, pGlu-Phe-Pro amide and pGlu-Gln-Pro amide, with similar structures to thyrotropin releasing hormone (TRH) have recently been identified but no studies of their in vivo activities have been reported previously. We describe here the ability of pGlu-Phe-Pro amide an...

journal_title：European journal of pharmacology

authors： Cremades A,Peñafiel R,Rausell V,Del Rio-Garcia J,Smyth DG

更新日期：1998-09-25 00:00:00

abstract：:The purpose of the present study was to characterize the nature of the behavioural response to substance P (SP) infusion into the substantia nigra and to evaluate this response in 6-hydroxydopamine (6-OHDA) caudate lesioned rats. The effects of SP infusions (3 microgram in 1 microliter bilaterally) were assessed in an...

journal_title：European journal of pharmacology

authors： Kelley AE,Iversen SD

更新日期：1979-12-07 00:00:00

abstract：:Experiments were conducted to explore the effects of Neuropeptide FF acting at spinal and supraspinal sites in models of chronic inflammatory or neuropathic pain and of acute pain. Neuropeptide FF was administered intrathecally (i.t.; 10.0, 25.0 and 50.0 nmol) or intracerebroventricularly (i.c.v.; 10.0, 12.5 and 15.0 ...

journal_title：European journal of pharmacology

authors： Altier N,Dray A,Ménard D,Henry JL

更新日期：2000-11-03 00:00:00

abstract：:A study was undertaken to ascertain why in the mouse vas deferens excitatory junction potentials facilitate whereas contractions depress during low frequency stimulation. In a set of contraction studies, where a conditioning stimulus was followed 2 s later by a test stimulus, depression in the first phase of contracti...

journal_title：European journal of pharmacology

authors： Karunanithi S,Lavidis NA,Bennett MR

更新日期：1994-08-11 00:00:00

abstract：:The role of protein kinase C in the endothelin-induced contraction was examined in the isolated rabbit saphenous vein in which endothelin-1, endothelin-3, sarafotoxin S6c and IRL 1620 (succinyl-[Glu9,Ala11,15]endothelin-1-(8-21))-induced contraction at the threshold concentrations of 0.1-1 pM. A selective inhibitor of...

journal_title：European journal of pharmacology

authors： Sudjarwo SA,Karaki H

更新日期：1995-12-27 00:00:00