Abstract:
:In a recent study we have shown that it was possible to recognize and record two independent behavioural patterns elicited by apomorphine (s.c.): one behaviour characterized by increased locomotion, sniffing and repetitive head and limb movements and another, characterized by compulsive gnawing. In the present study we have further characterized the gnawing and the locomotion patterns, their dependence on the experimental design and on the test environment. We found that the apomorphine-induced gnawing was easily modified by factors such as the design of the test-box and the habituation of the animal to the test-box. Locomotion, on the other hand was essentially independent of such factors and seemed more compulsive than the so-called "compulsive gnawing".
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Ljungberg T,Ungerstedt Udoi
10.1016/0014-2999(77)90250-3subject
Has Abstractpub_date
1977-11-15 00:00:00pages
147-51issue
2eissn
0014-2999issn
1879-0712pii
0014-2999(77)90250-3journal_volume
46pub_type
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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abstract::Type 2 diabetes mellitus (T2DM) is one of the risk factors for Parkinson's disease (PD). Insulin desensitisation has been observed in the brains of patients, which may promote neurodegeneration. Incretins are a family of growth factors that can re-sensitise insulin signalling. We have previously shown that mimetics of...
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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