A monoclonal antibody to calcitonin gene-related peptide abolishes capsaicin-induced gastroprotection.

abstract：:Peripheral electrical stimulation of the rat produced a "dose-dependent" analgesia both in intact and in spinal animals. Naloxone, a narcotic antagonist, almost completely reversed this analgesia. It is felt that peripheral electroanalgesia acts via the release of endogenous narcotic-like substances, the enkephalins, ...

journal_title：European journal of pharmacology

authors： Woolf CJ,Barrett GD,Mitchell D,Myers RA

更新日期：1977-10-01 00:00:00

abstract：:Phosphodiesterase inhibitors have been reported to be beneficial in cognitive and motor disorders. In the present study, we have investigated the effects of RO 20-1724 (PDE4 inhibitor) and sildenafil (PDE5 inhibitor) in 3-nitropropionic acid (3-NP) induced experimental Huntington's disease in rats. 3-Nitropropionic ac...

journal_title：European journal of pharmacology

authors： Thakur T,Sharma S,Kumar K,Deshmukh R,Sharma PL

更新日期：2013-08-15 00:00:00

abstract：:Single myelinated nerve fibres of Rana esculenta were investigated under current and potential clamp conditions at 20 degrees C. Under 2.5 mM phenobarbital, the amplitude of the action potential was reversibly reduced to 85.5 +/- 5% (n = 6), and the threshold potential was raised by 32% of the control in Ringer soluti...

journal_title：European journal of pharmacology

authors： Schwarz JR

更新日期：1979-06-01 00:00:00

abstract：:Striatal neurons in primary culture express a wide variety of adenylate cyclase-coupled receptors, and particularly dopamine (DA) D1 receptors, which are known to induce an increase in cyclic AMP production. To study desensitization of those receptor-mediated responses, neurons were incubated in the presence of satura...

journal_title：European journal of pharmacology

authors： Chneiweiss H,Glowinski J,Premont J

更新日期：1990-10-30 00:00:00

abstract：:Neuromedin K, a decapeptide isolated from porcine spinal cord and suggested to have tachykinin-like activity in vitro, produced reciprocal hind-limb scratching when injected intrathecally to mice. Neuromedin K was 20-60 times less potent in producing scratching (on a molar basis) than substance P, kassinin, eledoisin ...

journal_title：European journal of pharmacology

authors： Vaught JL,Post LJ,Jacoby HI,Wright D

更新日期：1984-08-17 00:00:00

abstract：:Pulmonary hypertension (PH) is a disease with a developmental origin characterized by obstructive vascular remodelling that is partially due to excessive pulmonary arterial smooth muscle cells (PASMCs) proliferation. Paeonol has important effects on vascular cell proliferation, migration, and inflammation, but researc...

journal_title：European journal of pharmacology

authors： Zhang L,Ma C,Gu R,Zhang M,Wang X,Yang L,Liu Y,Zhou Y,He S,Zhu D

更新日期：2018-09-05 00:00:00

abstract：:The peptides for-Met-Leu-Tyr-OMe, for-Met-Leu-Glu-OMe, for-Met-Leu-Asp-OMe and for-Met-Leu-Ser-OMe were synthesized to investigate the importance of a hydrophilic side chain of the residue at position 3 on biological activities of human neutrophils. A number of in vitro essays were carried out, including: chemotaxis, ...

journal_title：European journal of pharmacology

authors： Spisani S,Turchetti M,Varani K,Falzarano S,Cavicchioni G

更新日期：2003-05-23 00:00:00

abstract：:Ovarian cancer is the major cause of cancer death among female genital malignancies, and requires developing novel therapeutic measures. Immune escape and acquisition of tolerance by tumor cells are essential for cancer growth and progression. An immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) overexpression...

journal_title：European journal of pharmacology

authors： Kobayashi A,Tanizaki Y,Kimura A,Ishida Y,Nosaka M,Toujima S,Kuninaka Y,Minami S,Ino K,Kondo T

更新日期：2015-11-05 00:00:00

abstract：:Geniposide (GE) can effectively inhibit diabetic nephropathy (DN), but its mechanism is unclear. The objective of this study was to explore the antidiabetic nephropathy effects of GE both in high fat diet/streptozotocin-induced DN mice and in high glucose-induced podocyte model. Renal function in DN mice was evaluated...

journal_title：European journal of pharmacology

authors： Li F,Chen Y,Li Y,Huang M,Zhao W

更新日期：2020-11-05 00:00:00

abstract：:Disturbances in myocyte calcium homeostasis are hypothesized to be one cause for cardiac arrhythmia. The full development of this hypothesis requires (i) the identification of all sources of arrhythmogenic calcium and (ii) an understanding of the mechanism(s) through which calcium initiates arrhythmia. To these ends w...

journal_title：European journal of pharmacology

authors： Wolkowicz P,Umeda PK,Sharifov OF,White CR,Huang J,Mahtani H,Urthaler F

更新日期：2014-02-05 00:00:00

abstract：:Rats isolated at 16--18 days of age showed after 10--12 months a complex behavioural syndrome in which locomotor activity was markedly increased when compared to that of group-housed controls. The hyperactivity of the socially deprived animals was selectively blocked by clinically effective antidepressants but not by ...

journal_title：European journal of pharmacology

authors： Garzón J,Fuentes JA,Del Rio J

更新日期：1979-11-16 00:00:00

abstract：:We have investigated the mode of cardiovascular action of the stimulant methylhexaneamine (MHA) in terms of direct or indirect adrenergic actions in anaesthetised rats. Male and female rats were anaesthetised with pentobarbitone and pressor (changes in diastolic blood pressure) and cardioaccelerator responses to MHA w...

journal_title：European journal of pharmacology

authors： Alsufyani HA,Docherty JR

更新日期：2019-01-15 00:00:00

abstract：:Ro5-4864, diazepam and chlordiazepoxide inhibited the concanavalin A-induced [14C]serotonin release from rat mast cells dose dependently with IC30 values 38, 115 and 160 microM, respectively. They also inhibited concanavalin A-induced 45Ca uptake, with IC50 values 180, 860 and 1800 microM, respectively. Clonazepam sli...

journal_title：European journal of pharmacology

authors： Suzuki-Nishimura T,Sano T,Uchida MK

更新日期：1989-08-11 00:00:00

abstract：:The effects of omega-conotoxin GVIA (omega-CgTx), a peptide isolated from the venom of a marine mollusc, were studied in rat hippocampal neurons. Intracellular recordings from the CA1 area were made for the purpose in in vitro slice preparations. Omega-CgTx (0.1-1 microM) rapidly and irreversibly blocked the EPSP and ...

journal_title：European journal of pharmacology

authors： Dutar P,Rascol O,Lamour Y

更新日期：1989-12-19 00:00:00

abstract：:Immunocytochemical and Co(2+) uptake studies revealed that in primary cultures of rat cortical neurones, the majority of neurones are gamma-aminobutyric acid (GABA) immunopositive and can express Ca(2+)-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors. By fura-2 microfluorimetry, it...

journal_title：European journal of pharmacology

authors： Fischer W,Franke H,Scheibler P,Allgaier C,Illes P

更新日期：2002-03-01 00:00:00

abstract：:Three agents with K+ channel blocking activity, procaine, 4-aminopyridine (4-AP) and tetraethylammonium (TEA), were tested for inhibition of vasorelaxation and 86Rb+ efflux induced by cromakalim (BRL 34915), pinacidil and nicorandil in rabbit isolated mesenteric artery. The potency order for inhibition of vasorelaxati...

journal_title：European journal of pharmacology

authors： Wilson C,Coldwell MC,Howlett DR,Cooper SM,Hamilton TC

更新日期：1988-08-02 00:00:00

abstract：:1-Phenyl-3-(2-thiazolyl)-2-thiourea (200 mg/kg, 1 h) protected the adrenergic nerve plexus in the mouse atrium against the destructive action of i.v. 5,7-dihydroxytryptamine. Protection was also observed with ethanol (4 g/kg, 1 h) and with nialamide (50 mg/kg, 2 h). ...

journal_title：European journal of pharmacology

authors： Allis B,Cohen G

更新日期：1977-06-01 00:00:00

abstract：:Nucleos(t)ide analogues play pivotal roles as antiviral, cytotoxic or immunosuppressive agents. Here, we review recent reports of nucleoside analogues that exhibit broad-spectrum activity towards multiple life-threatening RNA and DNA viruses. We also present a discussion about nucleoside antimetabolites-approved antin...

journal_title：European journal of pharmacology

authors： Pastuch-Gawołek G,Gillner D,Król E,Walczak K,Wandzik I

更新日期：2019-12-15 00:00:00

abstract：:Microinjections of substance P (SP, 100 pmol) into the dorsal raphe nucleus (DRN) in conscious rats increased blood pressure and heart rate for 30-40 min. Concomitantly, the extracellular levels of 5-hydroxytryptamine (5-HT) in the ventral hippocampus, monitored by microdialysis, increased by 30% for 20 min compared w...

journal_title：European journal of pharmacology

authors： Gradin K,Qadri F,Nomikos GG,Hillegaart V,Svensson TH

更新日期：1992-08-06 00:00:00

abstract：:The kinetic and equilibrium binding properties of the 1,4-dihydropyridine activator [3H](-)-S-Bay K 8644 and the antagonist [3H](+)-PN 200-110 were determined in rat heart membrane particulate preparations at temperatures between 4 and 37 degrees C. The binding of [3H](-)-S-Bay K 8644 was temperature-dependent with a ...

journal_title：European journal of pharmacology

authors： Zheng W,Hawthorn M,Triggle DJ

更新日期：1991-10-14 00:00:00

abstract：:Endothelin (ET) and its receptor characteristics were studied in hyper- and hypo-thyroid states in the rats. Hyperthyroidism was induced by daily administration of thyroxine (0.1 mg/kg i.p.) for 8 weeks, while hypothyrodism was induced by daily administration of methimazole (10 mg/kg i.p.) for 8 weeks. The chronic adm...

journal_title：European journal of pharmacology

authors： Rebello S,Thompson EB,Gulati A

更新日期：1993-06-11 00:00:00

abstract：:The function of multidrug resistance-associated protein 2 (Mrp2) in the intestine and liver, as well as intestinal Mrp2 expression, was analyzed in CCl(4)-induced acute hepatic failure rats with hyperbilirubinemia. The plasma level of bilirubin glucuronides, endogenous Mrp2-substrates, was 26 microM at 24 h after CCl(...

journal_title：European journal of pharmacology

authors： Yokooji T,Murakami T,Yumoto R,Nagai J,Takano M

更新日期：2006-09-28 00:00:00

abstract：:Identification of natural products that have antitumor activity is invaluable to the chemoprevention and therapy of cancer. The embryos of lotus (Nelumbo nucifera) seeds are consumed in beverage in some parts of the world for their presumed health-benefiting effects. In this report we studied the effects of neferine, ...

journal_title：European journal of pharmacology

authors： Zhang X,Liu Z,Xu B,Sun Z,Gong Y,Shao C

更新日期：2012-02-29 00:00:00

abstract：:The effects of delta9-THC and its ethanol vehicle on pilocarpine-induced parotid gland secretions were investigated in rats. Single doses of delta9-THC (1, 2.5, 5 and 10 mg/kg) or 95% ethanol were administered i.v. prior to pilocarpine stimulation of saliva. Total flow, alpha-amylase and cation content of the induced ...

journal_title：European journal of pharmacology

authors： Nagle B,Tomassone BM,Digregorio J,Piraino A

更新日期：1976-12-01 00:00:00

abstract：:Statins have been demonstrated to elicit a broad range of cellular events resulting in an attenuation of the inflammatory response and enhanced protection to the components of the vessel wall. The present study was designed to examine the effect of pitavastatin on pathways associated with the proinflammatory gene, ear...

journal_title：European journal of pharmacology

authors： Lamon BD,Summers BD,Gotto AM Jr,Hajjar DP

更新日期：2009-03-15 00:00:00

abstract：:Carbocyclic thromboxane A2 (CTA2) constricted rabbit basilar and saphenous arteries. The contractions of the basilar artery, but not those of the saphenous artery, were potently inhibited by the calcium antagonist nimodipine. Selective inhibition of thromboxane-induced vasoconstriction of cerebral vessels may contribu...

journal_title：European journal of pharmacology

authors： Towart R,Perzborn E

更新日期：1981-01-16 00:00:00

abstract：:In this study, the anti-inflammatory effects of flavonoids isolated from the roots of Glycyrrhiza uralensis (Leguminosae), namely, isoliquiritin (the glycoside of isoliquirigenin) and isoliquiritigenin (the aglycone of isoliquiritin) were evaluated on lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. Isoliquirit...

journal_title：European journal of pharmacology

authors： Kim JY,Park SJ,Yun KJ,Cho YW,Park HJ,Lee KT

更新日期：2008-04-14 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD), a chronic progressive liver disease, covers a series of liver damage encompassing steatosis, nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis. However, there are no approved therapies for NAFLD. Herein, we characterize the pharmacological profile of ZLY16 ((E)-2-(4-...

journal_title：European journal of pharmacology

authors： Zhou Z,Deng L,Hu L,Ren Q,Cai Z,Wang B,Li Z,Zhang L

更新日期：2020-09-05 00:00:00

abstract：:Pharmacological strategies aimed at co-activating peroxisome proliferator-activated receptor-gamma (PPAR-γ)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway have shown promising results in alleviating myocardial injury. The aim of the study was to evaluate the role of chrysin, a PPAR-γ agonist, in ischemia-r...

journal_title：European journal of pharmacology

authors： Rani N,Arya DS

更新日期：2020-09-15 00:00:00

abstract：:The treatment of alcohol dependence mainly consists of psychological, social, and pharmacotherapeutic interventions aiming to reduce physical withdrawal, craving, and alcohol relapse. During the last years, it has become increasingly clear that adjuvant pharmacotherapy is efficacious especially in rehabilitation progr...

journal_title：European journal of pharmacology

authors： Kiefer F,Mann K

更新日期：2005-12-05 00:00:00