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Substance P injection into the dorsal raphe increases blood pressure and serotonin release in hippocampus of conscious rats.

Abstract：

:Microinjections of substance P (SP, 100 pmol) into the dorsal raphe nucleus (DRN) in conscious rats increased blood pressure and heart rate for 30-40 min. Concomitantly, the extracellular levels of 5-hydroxytryptamine (5-HT) in the ventral hippocampus, monitored by microdialysis, increased by 30% for 20 min compared with the vehicle control. Pretreatment with the 5-HT2 receptor antagonist, ritanserin (1 mg/kg i.v.), prevented the pressor response to SP but not the increase in heart rate. Pretreatment with the partial 5-HT1A receptor agonist, 8-methoxy-2-(N-2-chloroethyl-N-n-propyl)amino tetralin (8-MeO-CLEPAT, 10 micrograms/kg i.v.) prevented the increase in both blood pressure and heart rate. It is suggested that microinjections of SP into the DRN increase blood pressure through activation of serotonergic DRN neurons and that the postsynaptic receptor responsible for the pressor response is of the 5-HT2 type.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Gradin K,Qadri F,Nomikos GG,Hillegaart V,Svensson TH

doi

10.1016/0014-2999(92)90194-9

keywords:

subject

Has Abstract

pub_date

1992-08-06 00:00:00

pages

363-7

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(92)90194-9

journal_volume

218

pub_type

杂志文章

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