Tachykinin-like central activity of neuromedin K in mice.

Abstract:

:Neuromedin K, a decapeptide isolated from porcine spinal cord and suggested to have tachykinin-like activity in vitro, produced reciprocal hind-limb scratching when injected intrathecally to mice. Neuromedin K was 20-60 times less potent in producing scratching (on a molar basis) than substance P, kassinin, eledoisin or physalaemin. The activity of neuromedin K was blocked by the substance P antagonist [D-Pro2D-Trp7.9]substance P at doses of antagonist which effectively blocked the activity of the other tachykinins. These data provide the first evidence for tachykinin-like activity of neuromedin K in the central nervous system.

journal_name

Eur J Pharmacol

authors

Vaught JL,Post LJ,Jacoby HI,Wright D

doi

10.1016/0014-2999(84)90499-0

subject

Has Abstract

pub_date

1984-08-17 00:00:00

pages

355-7

issue

3-4

eissn

0014-2999

issn

1879-0712

pii

0014-2999(84)90499-0

journal_volume

103

pub_type

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