Abstract:
:Neuromedin K, a decapeptide isolated from porcine spinal cord and suggested to have tachykinin-like activity in vitro, produced reciprocal hind-limb scratching when injected intrathecally to mice. Neuromedin K was 20-60 times less potent in producing scratching (on a molar basis) than substance P, kassinin, eledoisin or physalaemin. The activity of neuromedin K was blocked by the substance P antagonist [D-Pro2D-Trp7.9]substance P at doses of antagonist which effectively blocked the activity of the other tachykinins. These data provide the first evidence for tachykinin-like activity of neuromedin K in the central nervous system.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Vaught JL,Post LJ,Jacoby HI,Wright Ddoi
10.1016/0014-2999(84)90499-0subject
Has Abstractpub_date
1984-08-17 00:00:00pages
355-7issue
3-4eissn
0014-2999issn
1879-0712pii
0014-2999(84)90499-0journal_volume
103pub_type
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