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Effect of intracoronary captopril on coronary blood flow and regional myocardial function in dogs.

Abstract：

:To evaluate the cardiac effect of an inhibitor of angiotensin-converting enzyme, the effect of intracoronary (i.c.) captopril on coronary blood flow and regional myocardial function was examined in the anesthetized open-chest dog. Blood flow of the left circumflex coronary artery (LCX), left ventricular pressure (LVP), aortic pressure (AoP) and regional myocardial segment length were measured continuously. Captopril i.v. (0.3 mg/kg) produced an immediate reduction in AoP and an increase in percent shortening of myocardial segments followed by a decrease in coronary vascular resistance and increases in heart rate and LVdP/dt. Reductions in LCX flow induced by i.c. angiotensin were attenuated and i.c. bradykinin-induced increases in LCX flow were augmented after captopril. On the contrary, i.c. infusion of captopril (0.01 mg/min) into the LCX caused no change in hemodynamic variables and myocardial shortening although responses to angiotensin I and bradykinin were markedly modified. These results suggest that captopril may have no direct cardiac effect.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Noguchi K,Kato T,Ito H,Aniya Y,Sakanashi M

doi

10.1016/0014-2999(85)90023-8

subject

Has Abstract

pub_date

1985-03-26 00:00:00

pages

11-9

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(85)90023-8

journal_volume

110

pub_type

杂志文章

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