A single dose of benzodiazepine hypnotics alters the sleep EEG in the subsequent drug-free night.

abstract：:Ezetimibe represents a new lipid lowering agent which inhibits cholesterol absorption. It effectively reduces low-density lipoprotein cholesterol when administered either alone or in combination with statins. However, its effect on cardiovascular mortality remains under question since it failed to demonstrate any sign...

journal_title：European journal of pharmacology

authors： Kalogirou M,Tsimihodimos V,Elisaf M

更新日期：2010-05-10 00:00:00

abstract：:The quaternary antagonist gallamine discriminates subpopulations of muscarinic receptors in the forebrain and brainstem of the rat and also modulates the binding of other muscarinic ligands via an allosteric mechanism in both brain regions. The calcium channel antagonist verapamil exhibits a similar allosteric effect ...

journal_title：European journal of pharmacology

authors： Ellis J,Seidenberg M

更新日期：1987-11-24 00:00:00

abstract：:Several mediators may be involved in the pathogenesis of inflammatory bowel disease, as well as in experimental colitis. The present work was conducted to investigate the effects of the two selective cyclooxygenase-2 inhibitors, celecoxib and rofecoxib, on experimentally induced colitis in rats. Rectal instillation of...

journal_title：European journal of pharmacology

authors： El-Medany A,Mahgoub A,Mustafa A,Arafa M,Morsi M

更新日期：2005-01-10 00:00:00

abstract：:Considerable evidence has appeared recently connecting the mechanism of action of some antidepressant drugs with the inhibition of the enzymes responsible for enkephalin degradation. Imipramine in vitro inhibits the enkephalin-degrading aminopeptidase MII and interacts with the enzyme in a mixed competitive-noncompeti...

journal_title：European journal of pharmacology

authors： Gallego M,Casis L,Casis O

更新日期：1998-10-30 00:00:00

abstract：:Cocaine dependence continues to be a worldwide public health concern. Although the majority of individuals reporting cocaine use do so via the intranasal route, relatively few laboratory experiments have examined the reinforcing effects of cocaine administered intranasally. The purpose of this experiment was to measur...

journal_title：European journal of pharmacology

authors： Stoops WW,Lile JA,Glaser PE,Hays LR,Rush CR

更新日期：2010-10-10 00:00:00

abstract：:Three apparently distinct pertussis toxin (PTX)-sensitive substrates, with Mrs of 39, 40 and 41 kDa, were identified in membranes prepared from the sino-atrial (SA) node and right atrium of bovine heart. Based on their biochemical characterization, the effects of guanine nucleotides/MgCl2 on their PTX-catalyzed [32P]A...

journal_title：European journal of pharmacology

authors： Braun AP,Gupta RC,Sulakhe PV

更新日期：1990-07-31 00:00:00

abstract：:Rheumatoid Arthritis is a chronic autoimmune disease with a complex disease pathogenesis leading to inflammation and destruction of synovial tissue in the joint. Several molecules lead to activation of immune pathways, including autoantibodies, Toll-Like Receptor ligands and cytokines. These pathways can cooperate to ...

journal_title：European journal of pharmacology

authors： Suurmond J,van der Velden D,Kuiper J,Bot I,Toes RE

更新日期：2016-05-05 00:00:00

abstract：:Estrogen-related receptor alpha (ERRα), one of orphan nuclear receptors, has been recently revealed as an oncogenic regulator in a variety of cancers. However, the linking gain of ERRα expression and cancer progression in cutaneous squamous cell carcinoma (cSCC) is largely unknown. Here, we showed that the mRNA and pr...

journal_title：European journal of pharmacology

authors： Chen H,Pan J,Zhang L,Chen L,Qi H,Zhong M,Shi X,Du J,Li Q

更新日期：2018-04-15 00:00:00

abstract：:We investigated the role of hippocampal group I metabotropic glutamate receptors (mGlu(1) receptors) in the retrieval process of spatial memory using 8-arm radial maze performance with 4 arms baited. In addition, the participation of the cholinergic system in memory deficits induced by mGlu(1) receptors antagonist was...

journal_title：European journal of pharmacology

authors： Mikami A,Masuoka T,Yasuda M,Yamamoto Y,Kamei C

更新日期：2007-12-01 00:00:00

abstract：:Apoptosis has received widespread attention for its essential roles in biology, medicine and cancer. We previously found that normal, human papillomavirus (HPV) 16-immortalized and their transformed endocervical cells were increasingly resistant to apoptosis induced by a cancer therapeutic drug. Here, analogously, ano...

journal_title：European journal of pharmacology

authors： Mo B,Pater A

更新日期：2003-04-25 00:00:00

abstract：:We investigated intracellular Ca2+ regulation in pancreatic acinar cells from rats with diabetes induced by a single injection of streptozotocin (80 mg/kg). Experiments were performed 2 days and 7 days after the injection of streptozotocin. The density of muscarinic receptors, measured by [3H]N-methyl scopolamine bind...

journal_title：European journal of pharmacology

authors： Komabayashi T,Sawada H,Izawa T,Kogo H

更新日期：1996-03-18 00:00:00

abstract：:The appearance of nephrotic syndromes such as proteinuria, hypoalbuminemia, hypercholesterolemia and increase in blood nitrogen urea, induced in rats by injection of puromycin aminonucleoside was markedly inhibited by oral administration of Dup 753 (losartan), a novel angiotensin II receptor antagonist, at a dose of 1...

journal_title：European journal of pharmacology

authors： Yayama K,Kawao M,Tujii H,Itoh N,Okamoto H

更新日期：1993-05-19 00:00:00

abstract：:NP-252, a new dihydropyridine derivative, and nifedipine non-competitively inhibited contractile responses to KCl and responses to Ca2+ in Ca(2+)-free medium containing KCl in rabbit aorta and renal, mesenteric, coronary and basilar arteries, mesenteric veins and vena cava. The effects of NP-252 in these smaller arter...

journal_title：European journal of pharmacology

authors： Shibata S,Satake N,Kodama I,Hester RK,Wang CG,Jino H,Hojo M,Tatsumi H,Gandhi V,Jones DJ

更新日期：1991-10-22 00:00:00

abstract：:To investigate the abnormal function of T and B lymphocytes involved in collagen-induced arthritis in DBA/1 mice and the regulation role of TACI-Ig on T and B lymphocytes, collagen-induced arthritis models were established in DBA/1 mice. Mice were divided randomly into eight groups, including normal, collagen-induced ...

journal_title：European journal of pharmacology

authors： Liu Y,Zhang L,Wu Y,Tong T,Zhao W,Li P,Huang M,Wang W,Fang J,Wei W

更新日期：2011-03-11 00:00:00

abstract：:Imatinib (IMA) is the standard treatment for CML; however, stopping IMA sometimes results in disease relapse, which suggests that leukemic stem cells (LSCs) remain in such patients, even after complete molecular remission has been achieved. Therefore, new strategies will be required to eradicate LSCs. The Janus kinase...

journal_title：European journal of pharmacology

authors： Yagi K,Shimada A,Sendo T

更新日期：2018-04-15 00:00:00

abstract：:Ouabain- and bumetanide-resistant potassium fluxes were measured in human erythrocytes incubated in a medium containing calcium and a calcium ionophore. Pharmacological concentrations of rat atrial natriuretic peptide stimulated these fluxes. Although human erythrocytes lack atrial natriuretic peptide receptors, our r...

journal_title：European journal of pharmacology

authors： Esparza N,Díez J

更新日期：1989-07-18 00:00:00

abstract：:ICI 169,369 is a chemically novel 5-HT antagonist that has higher affinity for the 5-HT2 binding sites in rat cortex than it has for 5-HT1 sites (Ki 1.79 x 10(-8) and 1.58 x 10(-6) M, respectively). In isolated tissue preparations ICI 169,369 was shown to be a competitive antagonist of 5-HT on the rabbit aorta, pig co...

journal_title：European journal of pharmacology

authors： Blackburn TP,Thornber CW,Pearce RJ,Cox B

更新日期：1988-06-10 00:00:00

abstract：:The present study was undertaken to investigate the involvement of chemical mediators in nasal allergic responses using histidine decarboxylase knockout (HDC-KO) mice. An allergic rhinitis model was developed in HDC-KO and wild-type mice by the intraperitoneal injection of ovalbumin, aluminum hydroxide gel and pertuss...

journal_title：European journal of pharmacology

authors： Rahman MA,Inoue T,Ishikawa T,Yatsuzuka R,Ohtsu H,Kamei C

更新日期：2007-07-19 00:00:00

abstract：:Pre- and postjunctional pA2 values of the muscarinic antagonist hexahydrosiladifenidol were determined with guinea-pig ileum and rat heart. Hexahydrosiladifenidol did not discriminate between pre- and postjunctional receptors within the same organ but was more potent on the ileum (20-80 times) than on the heart. It is...

journal_title：European journal of pharmacology

authors： Fuder H,Kilbinger H,Müller H

更新日期：1985-07-11 00:00:00

abstract：:Cd2+ competitively antagonizes Ca2+ in the evoked release of acetylcholine from nerve terminals in the frog sciatic-sartorius neuromuscular junction. The dissociation constant between Cd2+ and its receptor sites was calculated to be 1.7 microM. In agreement with previous work we found that brief exposures to 100-500 m...

journal_title：European journal of pharmacology

authors： Cooper GP,Manalis RS

更新日期：1984-04-06 00:00:00

abstract：:We have recently proposed that retinoic acid receptor (NR1B) is a promising target of neuroprotective therapy for intracerebral hemorrhage, since pretreatment of mice with an NR1B1/NR1B2 agonist Am80 attenuated various pathological and neurological abnormalities associated with the disease. In the present study we fur...

journal_title：European journal of pharmacology

authors： Matsushita H,Hijioka M,Hisatsune A,Isohama Y,Shudo K,Katsuki H

更新日期：2012-05-15 00:00:00

abstract：:1-Phenyl-3-(2-thiazolyl)-2-thiourea (200 mg/kg, 1 h) protected the adrenergic nerve plexus in the mouse atrium against the destructive action of i.v. 5,7-dihydroxytryptamine. Protection was also observed with ethanol (4 g/kg, 1 h) and with nialamide (50 mg/kg, 2 h). ...

journal_title：European journal of pharmacology

authors： Allis B,Cohen G

更新日期：1977-06-01 00:00:00

abstract：:Icariin is a major active component of the traditional herb Epimedium, also known as Horny Goat Weed. It has been extensively studied throughout the past several years and is known to exert anti-oxidative, anti-neuroinflammatory, and anti-apoptotic effects. It is now being considered as a potential therapeutic agent f...

journal_title：European journal of pharmacology

authors： Jin J,Wang H,Hua X,Chen D,Huang C,Chen Z

更新日期：2019-01-05 00:00:00

abstract：:The antifibrillatory and electrophysiologic actions of bepridil and butyl-methylenedioxyindene (BU-MDI), two intracellular calcium antagonists, were examined in anesthetized dogs. The administration of bepridil (1.0-10.0 mg/kg i.v.) significantly increased the electrical threshold for ventricular fibrillation determin...

journal_title：European journal of pharmacology

authors： Lynch JJ,Rahwan RG,Lucchesi BR

更新日期：1985-04-23 00:00:00

abstract：:To explore the possibility that raloxifene might influence an adipocyte differentiation and lipogenesis, we studied the effects of raloxifene on the expression of adiponectin and other peroxisome proliferator-activated receptor gamma targeting genes using the 3T3-L1 adipocytes. With standard adipogenic inducers, we ad...

journal_title：European journal of pharmacology

authors： Murase Y,Kobayashi J,Nohara A,Asano A,Yamaaki N,Suzuki K,Sato H,Mabuchi H

更新日期：2006-05-24 00:00:00

abstract：:The potency of the serotonin 1A (5-HT1A) agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT), to induce forepaw treading was increased 20-fold after co-treatment with the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI). DOI induced head twitches which were inhibited by 8-OHDPAT. The putative ...

journal_title：European journal of pharmacology

authors： Arnt J,Hyttel J

更新日期：1989-02-14 00:00:00

abstract：:Terfenadine and astemizole rarely cause cardiac arrhythmias by suppressing the cardiac rapid delayed rectifier K+ channel encoded by the human ether-a-go-go-related gene (HERG). Epinastine, however, has not been reported to have the adverse effect. We have therefore compared the effects of epinastine, terfenadine and ...

journal_title：European journal of pharmacology

authors： Chachin M,Katayama Y,Yamada M,Horio Y,Ohmura T,Kitagawa H,Uchida S,Kurachi Y

更新日期：1999-06-25 00:00:00

abstract：:The anticonvulsant activity of riluzole against sound-induced seizures was studied in the DBA/2 mouse model. Riluzole (0.1-4 mg kg(-1), intraperitoneal (i.p.)) produced dose-dependent effects with ED(50) values for the suppression of tonic, clonic and wild running phases of 0.72, 1.38 and 2.71 mg kg(-1), respectively....

journal_title：European journal of pharmacology

authors： De Sarro G,Siniscalchi A,Ferreri G,Gallelli L,De Sarro A

更新日期：2000-11-10 00:00:00

abstract：:We now describe the preparation and characterization of a novel radioligand, 2-[125I]iodo-5-methoxy-carbonylamino-N-acetyltryptamine (2-[125I]MCA-NAT), with high affinity and pharmacological selectivity for melatonin ML2 receptor sites. 2-[125I]MCA-NAT was prepared by introducing an [125I]iodine molecule on carbon 2 o...

journal_title：European journal of pharmacology

authors： Molinari EJ,North PC,Dubocovich ML

更新日期：1996-04-22 00:00:00

abstract：:The pharmacological characteristics of the binding of [3H]8-OH-DPAT ([3H]8-hydroxy-2(di-n-propylamino)tetralin, [125I]CYP ((-)[125I]iodocyanopindolol) (in the presence of 30 microM (-)isoprenaline) and [3H]mesulergine to 5-HT1 recognition sites were studied in rat and pig brain membranes. [3H]8-OH-DPAT bound in rat an...

journal_title：European journal of pharmacology

authors： Hoyer D,Engel G,Kalkman HO

更新日期：1985-11-26 00:00:00