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Imipramine inhibits soluble enkephalin-degrading aminopeptidase activity in vitro.

Abstract：

:Considerable evidence has appeared recently connecting the mechanism of action of some antidepressant drugs with the inhibition of the enzymes responsible for enkephalin degradation. Imipramine in vitro inhibits the enkephalin-degrading aminopeptidase MII and interacts with the enzyme in a mixed competitive-noncompetitive manner. The present work shows that imipramine in vitro also inhibits reversibly soluble enkephalin-degrading aminopeptidase activity in rat brain. Kinetic analysis showed that this enzyme has two different binding sites for the drug, and that imipramine interacts with the enzyme in a mixed noncompetitive-acompetitive way.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Gallego M,Casis L,Casis O

doi

10.1016/s0014-2999(98)00686-4

subject

Has Abstract

pub_date

1998-10-30 00:00:00

pages

113-6

issue

1

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(98)00686-4

journal_volume

360

pub_type

杂志文章

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