Abstract:
:The new dihydropyridine calcium channel antagonist S 11568 and its optical isomers, S 12967 and S 12968 (3 x 10(-6) to 10(-4) M), caused, unlike nifedipine (10(-4) M), equipotent and rapid endothelium-dependent relaxations and increased the content of cyclic GMP in rings of canine femoral arteries. These effects were observed in the presence of indomethacin and were prevented by methylene blue, hemoglobin and NG-monomethyl-L-arginine. Thus these effects must involve endothelium-derived relaxing factor (EDRF) and be distinct from the calcium channel antagonistic effect, which is stereoselective and of slow onset. The compounds did not potentiate relaxations of rings without endothelium to nitric oxide. In bioassay experiments, the compounds produced endothelium-dependent relaxation only when applied to endothelial donors. These results are compatible with an increased release of EDRF induced by the dihydropyridine compounds.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Vilaine JP,Biondi ML,Villeneuve N,Feletou M,Peglion JL,Vanhoutte PMdoi
10.1016/0014-2999(91)90362-tkeywords:
subject
Has Abstractpub_date
1991-05-02 00:00:00pages
41-8issue
1eissn
0014-2999issn
1879-0712pii
0014-2999(91)90362-Tjournal_volume
197pub_type
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