THIP and isoguvacine are partial agonists of GABA-stimulated benzodiazepine receptor binding.

abstract：:FACS analysis and [14C]-taurine efflux were used to determine whether activation of the volume-sensitive organic osmolyte/anion channel plays a role in cell cycle progression. This was achieved by examining the effects of a collection of (i) H(1) antagonists and tricyclic antidepressants with a known inhibitory effect...

journal_title：European journal of pharmacology

authors： Belsey MJ,Culliford SJ,Morley RM,Witchel HJ,Kozlowski RZ

更新日期：2003-08-08 00:00:00

abstract：:Adenosine has been reported to have beneficial effects against ischemic brain damage, although the mechanisms are not fully clarified. To examine the role of adenosine on the ischemia-evoked release of neurotransmitters, we applied a highly selective agonist for adenosine A1 receptor, 2-chloro-N6-cyclopentyladenosine ...

journal_title：European journal of pharmacology

authors： Goda H,Ooboshi H,Nakane H,Ibayashi S,Sadoshima S,Fujishima M

更新日期：1998-09-18 00:00:00

abstract：:Canine cerebral arterial strips denuded of endothelium responded to nicotine and transmural electrical stimulation with relaxations, which were abolished by NG-nitro-L-arginine and methylene blue. Magnitudes of relaxation did not differ in the arteries contracted with prostaglandin F2alpha and sumatriptan, an effectiv...

journal_title：European journal of pharmacology

authors： Ayajiki K,Fujioka H,Noda K,Okamura T,Toda N

更新日期：2001-05-18 00:00:00

abstract：:The effects of caffeine on Ca2+ fluxes and catecholamine secretion in bovine adrenal chromaffin cells were examined. Caffeine inhibited secretion. 45Ca2+ uptake and cytosolic Ca2+ concentration ([Ca2+]i) rise induced by the nicotinic receptor agonist 1.1-dimethyl- 4-phenylpiperazinium (DMPP) and the Na+ channel activa...

journal_title：European journal of pharmacology

authors： Liu PS,Lin YJ,Kao LS

更新日期：1995-11-30 00:00:00

abstract：:Rosmarinic acid (RA) is a polyphenolic compound with various pharmacological properties, including, anti-inflammatory, immunomodulatory, and neuroprotective, as well as having antioxidant and anticancer activities. This study evaluated the effects and mechanisms of RA in two racially different triple-negative breast c...

journal_title：European journal of pharmacology

authors： Messeha SS,Zarmouh NO,Asiri A,Soliman KFA

更新日期：2020-10-15 00:00:00

abstract：:Serotonin(1A) (5-HT(1A)) receptors are involved in anxiety. This study focuses on the role of genetic factors on the anxiety-related effects of 5-HT(1A) receptor stimulation using both a within subject design. The effects of 5-HT(1A) receptor activation were studied in high- and low-anxiety mice (129S6/SvEvTac (S6) an...

journal_title：European journal of pharmacology

authors： Bouwknecht JA,van der Gugten J,Groenink L,Olivier B,Paylor RE

更新日期：2004-06-21 00:00:00

abstract：:The cyclic AMP efflux from rat neostriatal slices induced by simultaneous activation of D-1 (stimulatory) and D-2 (inhibitory) dopamine receptors with 30 microM dopamine was inhibited by morphine (0.3-3 microM), [D-Ala2, D-Leu5]enkephalin (DADLE, 0.03-0.3 microM) but not by [D-Pen2, D-Pen5]enkephalin (DPDPE, 0.03-0.3 ...

journal_title：European journal of pharmacology

authors： Schoffelmeer AN,Hansen HA,Stoof JC,Mulder AH

更新日期：1985-12-03 00:00:00

abstract：:The pharmacological profiles of tachykinin receptors mediating the release of acetylcholine were examined in the isolated spinal cord of the neonatal rat. The acetylcholine release evoked by neurokinin A or acetyl-[Arg6,Pro9]substance P-(6-11) was depressed by the tachykinin antagonists, spantide and GR71251 at 10 mic...

journal_title：European journal of pharmacology

authors： Suzuki H,Yoshioka K,Maehara T,Hagan RM,Nakanishi S,Otsuka M

更新日期：1993-09-07 00:00:00

abstract：:After prolonged stimulation, the delta-opioid receptor becomes desensitized by regulatory mechanisms such as receptor phosphorylation, internalization and down-regulation. In this study, we demonstrate that morphine treatment causes phosphorylation of S363 in the C-terminus of the human delta-opioid receptor. Morphine...

journal_title：European journal of pharmacology

authors： Navratilova E,Eaton MC,Stropova D,Varga EV,Vanderah TW,Roeske WR,Yamamura HI

更新日期：2005-09-20 00:00:00

abstract：:In neuropathic rats sensitive to phentolamine (alpha-adrenoreceptor antagonist, 2 mg/kg, i.p.), prazosin (alpha1-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) had no significant effect. In neuropathic rats insen...

journal_title：European journal of pharmacology

authors： Kim SK,Min BI,Kim JH,Hwang BG,Yoo GY,Park DS,Na HS

更新日期：2005-10-31 00:00:00

abstract：:We have reported that tacrolimus (FK506), an immunosuppressive drug, and diclofenac, a non-steroidal anti-inflammatory drug, possess different modes of neuroprotective action. FK506 suppresses only thapsigargin-induced apoptosis in neuroblastoma SH-SY5Y cells while diclofenac reverses tunicamycin-induced as well as th...

journal_title：European journal of pharmacology

authors： Yamazaki T,Muramoto M,Okitsu O,Morikawa N,Kita Y

更新日期：2011-11-01 00:00:00

abstract：:Excess cytokine produced by inflammatory stimuli contributes to the progression of myocardial damage in myocarditis. Angiotensin-II has been shown to play a pivotal role in the pathophysiology of various organs, especially the cardiovascular system. Some angiotensin II type 1 receptor antagonists are reported to inhib...

journal_title：European journal of pharmacology

authors： Sukumaran V,Watanabe K,Veeraveedu PT,Ma M,Gurusamy N,Rajavel V,Suzuki K,Yamaguchi K,Kodama M,Aizawa Y

更新日期：2011-02-10 00:00:00

abstract：:The goal of this report is to present the results obtained with three new GABAB receptor antagonists. CGP 54062 has an IC50 in a GABAB binding test of 0.013 microM which is roughly 2500-fold lower than one of the most potent blockers known so far, CGP 35348 (IC50 = 34 microM). CGP 46381 and CGP 36742 have IC50s of 4.9...

journal_title：European journal of pharmacology

authors： Olpe HR,Steinmann MW,Ferrat T,Pozza MF,Greiner K,Brugger F,Froestl W,Mickel SJ,Bittiger H

更新日期：1993-03-23 00:00:00

abstract：:The effects of selective phosphodiesterase inhibitors, cyclic AMP (cAMP) elevating agents and stable analogues of cyclic nucleotides, on the release of arachidonate induced by N-formyl-Met-Leu-Phe (fMLP) were investigated on human peripheral blood mononuclear cells. The selective phosphodiesterase IV inhibitors, rolip...

journal_title：European journal of pharmacology

authors： Hichami A,Boichot E,Germain N,Legrand A,Moodley I,Lagente V

更新日期：1995-10-15 00:00:00

abstract：:Zolpidem has abuse potential, particularly among individuals with histories of drug abuse. This double-blind, placebo-controlled, cross over pilot study investigated the subjective effects of zolpidem (10 mg) in drug-naïve females. Over the course of a 5-h period vital signs were monitored and a series of computerized...

journal_title：European journal of pharmacology

authors： Licata SC,Penetar DM,Dunlap S,Lukas SE

更新日期：2008-11-19 00:00:00

abstract：:Rutin exhibits antidiabetic, antioxidant and anti-inflammatory properties, which makes rutin an attractive candidate for diabetic complications. The present study was designed to investigate the potential effect of rutin on diabetic neuropathy. After induction of diabetic neuropathy, rutin (5mg/kg, 25mg/kg and 50mg/kg...

journal_title：European journal of pharmacology

authors： Tian R,Yang W,Xue Q,Gao L,Huo J,Ren D,Chen X

更新日期：2016-01-15 00:00:00

abstract：:The influence of the membrane environment on the alpha 1-adrenoceptor has been investigated by examining the effect of phospholipase digestion on the binding of [3H]prazosin to aortic and hepatic membranes. Membrane digestion by phospholipase A2 and phospholipase C was found to markedly reduce prazosin binding to the ...

journal_title：European journal of pharmacology

authors： Shreeve SM,Valliere JE

更新日期：1992-05-12 00:00:00

abstract：:Diazepam (10(-5)-3 X 10(-4) M) selectively enhanced the negative inotropic responses of guinea-pig atria and the relaxation of guinea-pig taenia coli caused by adenosine and ATP. In the atria, the effect of 2-chloroadenosine, a stable analog of adenosine, was not affected by diazepam. Segments of guinea-pig atria or t...

journal_title：European journal of pharmacology

authors： Moritoki H,Fukuda H,Kotani M,Ueyama T,Ishida Y,Takei M

更新日期：1985-07-11 00:00:00

abstract：:Emodin, 1,3,8-trihydroxy-6-methyl-anthraquinone, is an anthraquinone derivative from the roots of Rheum officinale Baill that has been used to treat many diseases in digestive system for thousands of years. This study is to disclose the mechanism of Emodin to treat cholestatic hepatitis via anti-inflammatory pathway. ...

journal_title：European journal of pharmacology

authors： Ding Y,Zhao L,Mei H,Zhang SL,Huang ZH,Duan YY,Ye P

更新日期：2008-08-20 00:00:00

abstract：:In this study the desensitizing power of increasing concentrations of resiniferatoxin applied topically to the bladder mucosa, and the irritating properties of the most effective desensitizing dose, were determined with the aid of the spinal expression of the proto-oncogene c-fos. Desensitization was assessed by the d...

journal_title：European journal of pharmacology

authors： Avelino A,Cruz F,Coimbra A

更新日期：1999-07-28 00:00:00

abstract：:Nerve growth factor (NGF) is known to regulate the development and survival of select populations of neurons via its binding/activation of the TrkA and p75(NTR) receptors. However, in some physiological circumstances NGF dysregulation can result in debilitating pathologies, including diabetic neuropathies, interstitia...

journal_title：European journal of pharmacology

authors： Eibl JK,Strasser BC,Ross GM

更新日期：2013-05-15 00:00:00

abstract：:We have reported previously that the dipeptidyl peptidase IV inhibitor Ile-Pro-Ile had an antihyperalgesic action in rats when given intrathecally in the carrageenan-induced hyperalgesia, as detected by the Randall-Selitto test. Vildagliptin, a non-peptide inhibitor of the same enzyme, which is already on the market a...

journal_title：European journal of pharmacology

authors： Király K,Lambeir AM,Szalai J,Szentirmay A,Luyten W,Barna I,Puskár Z,Kozsurek M,Rónai AZ

更新日期：2011-01-10 00:00:00

abstract：:Dipeptidyl peptidase IV (DPP IV) is the primary inactivator of glucoregulatory incretin hormones. This has lead to development of DPP IV inhibitors as a new class of agents for the treatment of type 2 diabetes. Recent reports indicate that other antidiabetic drugs, such as metformin, may also have inhibitory effects o...

journal_title：European journal of pharmacology

authors： Duffy NA,Green BD,Irwin N,Gault VA,McKillop AM,O'Harte FP,Flatt PR

更新日期：2007-07-30 00:00:00

abstract：:The GABA-inhibitory action of bicuculline on lobster muscle was critically re-examined. Bicuculline (20-100 micrometers) depressed the GABA-evoked conductance increase in a reversible manner, the double reciprocal transformation of the GABA dose/conductance curves remaining linear. If bicuculline was assumed to be a p...

journal_title：European journal of pharmacology

authors： Smart TG,Constanti A

更新日期：1981-03-05 00:00:00

abstract：:Renal adrenergic interactions of intravenously and intrarenal arterially administered angiotensin II were studied in the anesthetized rabbit. Systemic arterial blood pressure and left renal blood flow were monitored. Bolus doses of angiotensin II, 50 and 100 ng/kg given intravenously, caused an immediate reduction in ...

journal_title：European journal of pharmacology

authors： Chen K,Zimmerman BG

更新日期：1995-09-25 00:00:00

abstract：:Cardiovascular and behavioral responses induced by intravenous administration of the serotonin (5-HT)1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), were studied in conscious normotensive rats either after a single administration, after repeated subcutaneous treatments (1 mg/kg daily for 3 day...

journal_title：European journal of pharmacology

authors： Kolbasa KP,McCall RB,Ludens JH

更新日期：1991-02-14 00:00:00

abstract：:In this study, the anti-inflammatory effects of flavonoids isolated from the roots of Glycyrrhiza uralensis (Leguminosae), namely, isoliquiritin (the glycoside of isoliquirigenin) and isoliquiritigenin (the aglycone of isoliquiritin) were evaluated on lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. Isoliquirit...

journal_title：European journal of pharmacology

authors： Kim JY,Park SJ,Yun KJ,Cho YW,Park HJ,Lee KT

更新日期：2008-04-14 00:00:00

abstract：:In this study, rutaecarpine was tested for its antiplatelet activities in human platelet-rich plasma. In human platelet-rich plasma, rutaecarpine (40-200 microM) inhibited aggregation stimulated by a variety of agonists (i.e., collagen, ADP, adrenaline and arachidonic acid). The antiplatelet activity of rutaecarpine (...

journal_title：European journal of pharmacology

authors： Sheu JR,Hung WC,Lee YM,Yen MH

更新日期：1996-12-30 00:00:00

abstract：:The aim of the present study was to find out the mechanism by which the inflammatory mediator, bradykinin, induces an increase of the cytosolic Ca(2+) concentration ([Ca(2+)](i)) in enteric neurons. For this purpose, ganglia in the isolated submucosa from rat colon were loaded with the Ca(2+)-sensitive dye, fura-2, an...

journal_title：European journal of pharmacology

authors： Rehn M,Diener M

更新日期：2012-04-15 00:00:00

abstract：:The dopamine transporter removes the neurotransmitter from the synapse, regulating dopamine availability. The transporter can be internalized and its function is blocked by cocaine and other ligands. Melittin inhibits dopamine transporter function and causes internalization of the recombinant transporter in stably tra...

journal_title：European journal of pharmacology

authors： Keith DJ,Wolfrum K,Eshleman AJ,Janowsky A

更新日期：2012-09-05 00:00:00