Abstract:
:The pharmacological profiles of tachykinin receptors mediating the release of acetylcholine were examined in the isolated spinal cord of the neonatal rat. The acetylcholine release evoked by neurokinin A or acetyl-[Arg6,Pro9]substance P-(6-11) was depressed by the tachykinin antagonists, spantide and GR71251 at 10 microM, whereas the release evoked by substance P (0.3 microM) or neurokinin B (0.3 microM) was not affected by these tachykinin antagonists. Polymerase chain reaction amplification of rat spinal cord cDNA and sequence analysis revealed the presence of a substantial amount of fragments having sequences identical to that of the NK1 or NK3 receptor, but only a few having a sequence identical to that of the NK2 receptor. These results suggest that in the neonatal rat spinal cord a novel subtype of tachykinin receptor similar but not identical to the classical NK1 receptor is involved in tachykinin-evoked acetylcholine release.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Suzuki H,Yoshioka K,Maehara T,Hagan RM,Nakanishi S,Otsuka Mdoi
10.1016/0014-2999(93)90939-fsubject
Has Abstractpub_date
1993-09-07 00:00:00pages
105-10issue
1eissn
0014-2999issn
1879-0712pii
0014-2999(93)90939-Fjournal_volume
241pub_type
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