当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats.

Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats.

Abstract：

:In neuropathic rats sensitive to phentolamine (alpha-adrenoreceptor antagonist, 2 mg/kg, i.p.), prazosin (alpha1-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) had no significant effect. In neuropathic rats insensitive to phentolamine, yohimbine significantly exacerbated cold allodynia whereas prazosin had no significant effect. These results suggest that the individual differences in the sensitivity of cold allodynia to phentolamine may be due to the difference in the alpha-adrenoreceptor subtype predominantly involved in cold allodynia.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Kim SK,Min BI,Kim JH,Hwang BG,Yoo GY,Park DS,Na HS

doi

10.1016/j.ejphar.2005.08.030

keywords:

subject

Has Abstract

pub_date

2005-10-31 00:00:00

pages

64-6

issue

1-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(05)00857-5

journal_volume

523

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF PHARMACOLOGY文献大全
  • Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cells.

    abstract：:Cancer cell lines derived from hepatocytes have an altered phenotype and they lack hepatocyte-specific functions. It is at least partly due to the under-expression of transcription factors such as hepatocyte nuclear factor 4α (HNF4α), steroid receptor co-activator 1 (SRC1) etc. Recently, a strategy of transient transf...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2011.07.049

    authors： Novotna A,Doricakova A,Vrzal R,Pavek P,Dvorak Z

    更新日期：2011-11-01 00:00:00

  • Berberine ameliorates TNBS-induced colitis by inhibiting lipid peroxidation, enterobacterial growth and NF-κB activation.

    abstract：:Berberine, which is a major constituent of the rhizome of Coptidis japonica (CJ), inhibits IL-8 production in colonic epithelial cells and improves 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice. In our preliminary studies, berberine inhibited lipid peroxidation in liposomes prepared from l-α-phosp...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2010.08.046

    authors： Lee IA,Hyun YJ,Kim DH

    更新日期：2010-12-01 00:00:00

  • Leukotrienes reduce nociceptive responses to bradykinin.

    abstract：:The biotransformation of arachidonic acid leads to two important groups of inflammatory mediators, the leukotrienes and the prostaglandins. Hyperalgesic effects have been demonstrated for prostaglandins in a variety of animal models but the effects of leukotrienes on inflammatory pain are less well documented. Using t...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(84)90653-8

    authors： Schweizer A,Brom R,Glatt M,Bray MA

    更新日期：1984-10-01 00:00:00

  • Acid and stretch, but not capsaicin, are effective stimuli for ATP release in the porcine bladder mucosa: Are ASIC and TRPV1 receptors involved?

    abstract：:Stretch-evoked ATP release from the bladder mucosa is a key event in signaling bladder fullness. Our aim was to examine whether acid and capsaicin can also release ATP and to determine the receptors involved, using agonists and antagonists at TRPV1 and acid-sensing ion channels (ASICs). Strips of porcine bladder mucos...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2012.02.041

    authors： Sadananda P,Kao FC,Liu L,Mansfield KJ,Burcher E

    更新日期：2012-05-15 00:00:00

  • The atypical antipsychotic sertindole enhances efflux of dopamine and its metabolites in the rat cortex and striatum.

    abstract：:Previous studies have shown that sertindole (1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl ]-2 imidazolidinone), an atypical antipsychotic drug that is a potent 5-HT2A and dopamine D2 receptor antagonist, preferentially affects mesocorticolimbic rather than mesostriatal dopamine neurons. Usin...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(98)00936-4

    authors： Watanabe M,Hagino Y

    更新日期：1999-02-12 00:00:00

  • Mechanisms underlying ATP-induced endothelium-dependent contractions in the SHR aorta.

    abstract：:In mature spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats, acetylcholine, the calcium ionophore A 23187 and ATP release endothelium-derived contracting factor (EDCF), cyclooxygenase (COX) derivatives that activate thromboxane-endoperoxide (TP) receptors on vascular smooth muscle. The EDCFs released by ace...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2006.10.050

    authors： Gluais P,Vanhoutte PM,Félétou M

    更新日期：2007-02-05 00:00:00

  • Inhibitory effects of hesperetin on Kv1.5 potassium channels stably expressed in HEK 293 cells and ultra-rapid delayed rectifier K(+) current in human atrial myocytes.

    abstract：:In the present study, the inhibitory effects of hesperetin (HSP) on human cardiac Kv1.5 channels expressed in HEK 293 cells and the ultra-rapid delayed rectifier K(+) current (Ikur) in human atrial myocytes were examined by using the whole-cell configuration of the patch-clamp techniques. We found that hesperetin rapi...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2016.07.015

    authors： Wang H,Wang HF,Wang C,Chen YF,Ma R,Xiang JZ,Du XL,Tang Q

    更新日期：2016-10-15 00:00:00

  • Increase of glucocorticoids is not required for the acquisition, but hinders the extinction, of lithium-induced conditioned taste aversion.

    abstract：:Lithium chloride at doses sufficient to induce conditioned taste aversion (CTA) causes c-Fos expression in the paraventricular nucleus and increases the plasma level of corticosterone with activation of the hypothalamic-pituitary-adrenal axis. This study was conducted to define the role of glucocorticoid in the acquis...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2014.02.017

    authors： Kim KN,Kim BT,Kim YS,Lee JH,Jahng JW

    更新日期：2014-05-05 00:00:00

  • Inhibitors of 1,2-diacylglycerol kinase potentiate the TRH-induced stimulation of Ca2+-activated K+ current.

    abstract：:Transient activation of the outward K+ current caused by a rise in the cytosolic free Ca2+ concentration, [Ca2+]i was the predominant change in plasma membrane ion flux during the first phase of thyrotropin-releasing hormone (TRH) action on pituitary cells. Following the intracellular application of inhibitors of 1,2-...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0922-4106(89)90046-1

    authors： Mollard P,Vacher P,Dufy B,Winiger BP,Schlegel W

    更新日期：1989-03-07 00:00:00

  • Intradermal application of nociceptin increases vascular permeability in rats: the possible involvement of histamine release from mast cells.

    abstract：:Intradermal application of nociceptin was used to investigate its in vivo effect on the inflammatory response in rats. Intradermal nociceptin (5 pmol/site-5 nmol/site) increased vascular permeability in a dose-dependent manner. The increased vascular permeability by nociceptin (5 nmol/site) was dose-dependently inhibi...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(00)00746-9

    authors： Kimura T,Kitaichi K,Hiramatsu K,Yoshida M,Ito Y,Kume H,Yamaki K,Suzuki R,Takagi K

    更新日期：2000-11-03 00:00:00

  • Homovanillic acid in caudate and pre-frontal cortex following neuroleptics.

    abstract：:Homovanillic acid (HVA) was measured in rat caudate and pre-frontal cortex 3 h following a single dose of a variety of neuroleptics. Thioridazine, haloperidol, fluphenazine, and metoclopramide increased HVA levels in caudate more than in pre-frontal cortex; whereas sulpiride and clozapine produced greater increases in...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(84)90438-2

    authors： Bowers MB Jr

    更新日期：1984-03-16 00:00:00

  • Tryptase-induced airway microvascular leakage in guinea pigs: involvement of tachykinins and leukotrienes.

    abstract：:Tryptase, a serine protease synthesized by and stored in mast cells, is implicated as an important mediator in the pathogenesis of airway inflammation. In this study, tryptase was evaluated for its ability to induce microvascular leakage into the airways of guinea pigs. Dose- and time-dependent increases in airway mic...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(01)00960-8

    authors： Greenfeder S,Sehring S,McHugh N,Corboz M,Rivelli M,Anthes JC,Billah M,Egan RW,Chapman RW

    更新日期：2001-05-11 00:00:00

  • Involvement of tyrosine kinase in peroxynitrite-induced preconditioning in rat isolated heart.

    abstract：:We have investigated the role of tyrosine kinase in the antiarrhythmic effects of peroxynitrite preconditioning in rat isolated heart by using a tyrosine phosphatase inhibitor, sodium orthovanadate, and tyrosine kinase inhibitors, genistein and tyrphostin. Rat hearts were preconditioned by peroxynitrite administration...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(03)01377-3

    authors： Söylemez S,Demiryürek AT,Kanzik I

    更新日期：2003-03-19 00:00:00

  • Analgesic and anti-edemic properties of etifoxine in models of inflammatory sensitization.

    abstract：:Inflammatory processes are critical promoting factors of chronic pain states, mostly by inducing peripheral and central sensitization of the nociceptive system. These processes are associated with a massive increase in glutamatergic transmission, sometimes facilitated by spinal disinhibition. In this study, we used et...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2018.12.018

    authors： Gazzo G,Girard P,Kamoun N,Verleye M,Poisbeau P

    更新日期：2019-01-15 00:00:00

  • Inhibitory effect of fluvoxamine on β-casein expression via a serotonin-independent mechanism in human mammary epithelial cells.

    abstract：:Selective serotonin reuptake inhibitors (SSRIs) are widely used as a first-line therapy in postpartum depression. The objective of this study was to determine the mechanism underlying the inhibitory effects of the SSRI, fluvoxamine, on β-casein expression, an indicator of lactation, in MCF-12A human mammary epithelial...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2015.09.038

    authors： Chiba T,Maeda T,Kimura S,Morimoto Y,Sanbe A,Ueda H,Kudo K

    更新日期：2015-11-05 00:00:00

  • The kappa-opioid receptor agonist, U50,488H, exerts antidystonic activity in a mutant hamster model of generalized dystonia.

    abstract：:The kappa-opioid receptor agonist, U50,488H (trans-(+-)-3,4-dichloro-N-methyl-[2-(1-pyrrolidinyl)-cyclohexyl]- benzeneacetamide), has recently been reported to induce dystonia after s.c. administration of 5-10 mg/kg in guinea pigs. The dystonic movements observed in response to U50,488H resembled those previously repo...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(93)90600-m

    authors： Richter A,Löscher W

    更新日期：1993-05-19 00:00:00

  • Dup 753 prevents the development of puromycin aminonucleoside-induced nephrosis.

    abstract：:The appearance of nephrotic syndromes such as proteinuria, hypoalbuminemia, hypercholesterolemia and increase in blood nitrogen urea, induced in rats by injection of puromycin aminonucleoside was markedly inhibited by oral administration of Dup 753 (losartan), a novel angiotensin II receptor antagonist, at a dose of 1...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(93)90609-l

    authors： Yayama K,Kawao M,Tujii H,Itoh N,Okamoto H

    更新日期：1993-05-19 00:00:00

  • Changes in naloxone and haloperidol effects during the development of captivity-induced jumping stereotypy in bank voles.

    abstract：:Captivity-induced stereotypies in bank voles (Clethrionomys glareolus) were inhibited at the age of 1, 2, 4, 6, 8 and 10 months by 0.2 mg/kg haloperidol s.c., while 35 mg/kg naloxone s.c. only inhibited them at the age of 4-6 months. Other activities were not significantly inhibited. The change in the naloxone effect ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(88)90583-3

    authors： Kennes D,Odberg FO,Bouquet Y,De Rycke PH

    更新日期：1988-08-09 00:00:00

  • Regulation of NO-dependent acetylcholine relaxation by K+ channels and the Na+-K+ ATPase pump in porcine internal mammary artery.

    abstract：:This study was designed to determine whether K+ channels play a role in nitric oxide (NO)-dependent acetylcholine relaxation in porcine internal mammary artery (IMA). IMA segments were isolated and mounted in organ baths to record isometric tension. Acetylcholine-elicited vasodilation was abolished by muscarinic recep...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2010.05.004

    authors： Pagán RM,Prieto D,Hernández M,Correa C,García-Sacristán A,Benedito S,Martínez AC

    更新日期：2010-09-01 00:00:00

  • Influence of a Ca2+ channel agonist, Bay k-8644, on the anticonvulsant activity of NMDA and non-NMDA receptor antagonists.

    abstract：:Bay k-8644 (methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoro- methylphenyl)-pyridine-5-carboxylate) (a Ca2+ channel agonist of the dihydropyridine class) at 5 mg/kg (s.c.) impaired the anticonvulsant activities of two competitive NMDA receptor antagonists, CGP 37849 (D,L-(E)-2-amino-4-methyl-5-phosphono-3-penten...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(94)90644-0

    authors： Czuczwar SJ,Gasior M,Turski WA,Kleinrok Z

    更新日期：1994-10-13 00:00:00

  • Are beta-adrenoreceptors involved in the intestinal absorption and tissue distribution of iron in the rat?

    abstract：:59Fe was incorporated in vivo into intestinal sacs prepared in iron deficient rats and 59Fe counts were detected in blood, spleen, liver, femur and intestine. The i.v. injection of isoproterenol (i.v. 2 micrograms/rat) or N',O'-dibutyryladenosine 3',5'-cyclic monophosphate (10 microM/100 g b.w.) enhanced significantly...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(84)90015-3

    authors： Gutnisky A,Borda ES,Gimeno AL

    更新日期：1984-05-04 00:00:00

  • Melatonin affords protection against kainate-induced in vitro lipid peroxidation in brain.

    abstract：:Melatonin protection against in vitro kainic acid-induced oxidative damage in rat brain is shown. Brain disrupted cell homogenates were incubated with different concentrations of kainate and with or without different concentrations of melatonin. The concentration of malonaldehyde and 4-hydroxyalkenals was measured as ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(96)00241-5

    authors： Melchiorri D,Reiter RJ,Chen LD,Sewerynek E,Nisticò G

    更新日期：1996-06-03 00:00:00

  • Antagonism by neuroleptics of serotonin 5-HT1A and 5-HT2 receptors of normal human brain in vitro.

    abstract：:Using radioligand binding techniques and human frontal cortex, we determined the equilibrium dissociation constants (KDs) of 17 neuroleptics at the serotonin 5-HT1A and serotonin 5-HT2 receptors with [3H]WB4101 and [3H]ketanserin, respectively. At the serotonin 5-HT1A receptor, the most and least potent neuroleptics w...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(87)90544-9

    authors： Wander TJ,Nelson A,Okazaki H,Richelson E

    更新日期：1987-11-10 00:00:00

  • Tricyclic antidepressants activate the pituitary-adrenal axis in the rat. Tolerance to repeated drug administration.

    abstract：:The effects of acute chronic administration of tricyclic antidepressants on the pituitary-adrenal axis were studied in adult male rats. Acute administration of desipramine, imipramine and chlorimipramine activated the pituitary-adrenal axis. The effect of imipramine was found to be of short duration with a significant...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(87)90812-0

    authors： Armario A,García-Marquez C

    更新日期：1987-08-11 00:00:00

  • Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease.

    abstract：:The basic symptoms of Alzheimer's dementia, i.e., a loss in cognitive function, are due to impaired nicotinic cholinergic neurotransmission. To compensate for this impairment by drug treatment, blockers of the acetylcholine-degrading enzyme acetylcholinesterase are applied, even though this approach obviously is prone...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(00)00093-5

    authors： Maelicke A,Albuquerque EX

    更新日期：2000-03-30 00:00:00

  • Protective effects of selegiline and desmethylselegiline against N-methyl-D-aspartate-induced rat retinal damage.

    abstract：:Selegiline, a therapeutic agent of Parkinson's disease, and its metabolite, desmethylselegiline, were explored for their neuroprotective effects against N-methyl-D-aspartate (NMDA)-induced cell death in rat retina. Morphometric analysis of the retina revealed that an intravitreal injection of NMDA induced a significan...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(02)02729-2

    authors： Takahata K,Katsuki H,Kobayashi Y,Muraoka S,Yoneda F,Kume T,Kashii S,Honda Y,Akaike A

    更新日期：2003-01-01 00:00:00

  • Differential antagonism of the anticonflict effects of typical and atypical anxiolytics.

    abstract：:Selected benzodiazepine and non-benzodiazepine agents were studied alone or in the presence of benzodiazepine antagonists in the shock-induced suppression of drinking (SSD) procedure in rats. The disinhibitory activity of chlordiazepoxide, CL218,872, zopiclone and CGS 9896 was antagonized by two benzodiazepine antagon...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(82)90331-4

    authors： Patel JB,Martin C,Malick JB

    更新日期：1982-12-24 00:00:00

  • Effects of benzodiazepine receptor inverse agonists on locomotor activity and exploration in mice.

    abstract：:This study investigates the effects of benzodiazepine receptor inverse agonists on the locomotor and exploratory behaviour of mice when tested in a familiar environment. The weak partial inverse agonist Ro 15-3505 (0.3, 1, 3 mg/kg i.p.) significantly increased locomotion and hole-dipping in habituated mice. However, t...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(92)90701-5

    authors： Jackson HC,Nutt DJ

    更新日期：1992-10-20 00:00:00

  • Theophylline inhibits late asthmatic reactions induced by toluene diisocyanate in sensitised subjects.

    abstract：:Toluene diisocyanate (TDI)-induced asthma is a frequent occupational airway disease. To determine whether a calibrated dosage of oral slow-release theophylline inhibits asthmatic reactions and the associated increase of airway responsiveness to methacholine induced by TDI, we examined six asthmatic subjects who develo...

    journal_title：European journal of pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0926-6917(92)90010-a

    authors： Crescioli S,De Marzo N,Boschetto P,Spinazzi A,Plebani M,Mapp CE,Fabbri LM,Ciaccia A

    更新日期：1992-05-01 00:00:00

  • G proteins in aortic endothelial cells and bradykinin-induced formation of nitric oxide.

    abstract：:In bovine aortic endothelial cells (BAEC), pertussis toxin (PTx) ADP-ribosylated two major substrates with apparent molecular masses of 40 and 41 kDa, whereas cholera toxin (CTx) ADP-ribosylated two other substrates of 44 and 50 kDa. [alpha-32P]GTP bound to three bands in the 22-27 kDa range. Immunoblot analysis revea...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0922-4106(93)90068-k

    authors： Gil-Longo J,Dufour MN,Guillon G,Lugnier C

    更新日期：1993-10-15 00:00:00