Muscarinic receptors modulate the afterhyperpolarizing potential in neostriatal neurons.

abstract：:Using a batch method for incubation of hippocampal slices, we have examined the effects of 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (RU24969) and (m-trifluoromethylphenyl)piperazine (TFMPP) on release of endogenous 5-hydroxytryotamine (5-HT). Release of 5-HT from slices was enhanced by RU24969 and TFMPP ...

journal_title：European journal of pharmacology

authors： Auerbach SB,Kamalakannan N,Rutter JJ

更新日期：1990-11-06 00:00:00

abstract：:The concentration of blood glucose was measured in rats after administration of a number of drugs characterized as dopamine agonists. Compounds that cause release of dopamine, or agents that block the reuptake of dopamine, did not elevate blood glucose. Some direct dopamine receptor stimulants (lergotrile, bromocripti...

journal_title：European journal of pharmacology

authors： Schmidt MJ,Root MA,Hall JL

更新日期：1983-06-03 00:00:00

abstract：:The contribution of tyrosine kinase activity to vasoreactivity in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats was investigated on isolated aortic preparations by the use of two tyrosine kinase inhibitors: methyl-2,5-dihydroxycinnamate (30 microM) and genistein (30 microM). The pretreatmen...

journal_title：European journal of pharmacology

authors： Zerrouk A,Auguet M,Dabiré H,Brisac AM,Safar M,Chabrier PE

更新日期：1999-06-11 00:00:00

abstract：:Nausea and vomiting are among the most frequently occurring symptoms observed by clinicians. While advances have been made in understanding both the physiological as well as the neurophysiological pathways involved in nausea and vomiting, the final common pathway(s) for emesis have yet to be defined. Regardless of the...

journal_title：European journal of pharmacology

authors： Babic T,Browning KN

更新日期：2014-01-05 00:00:00

abstract：:Corticotropin releasing factor (CRF) is a hypothalamic hormone that also displays autocrine/paracrine roles at peripheral sites. High concentrations of CRF have been identified in endothelial cells and other inflammatory tissues. We investigated the effects of CRF and antagonists in the regulation of prostaglandin syn...

journal_title：European journal of pharmacology

authors： Fleisher-Berkovich S,Rimon G,Danon A

更新日期：1998-07-24 00:00:00

abstract：:Paclitaxel, an antitumoral drug, was used in a single dose (29 mg/kg i.p.) as an injury agent for inducing transient suppression of hematopoiesis in a murine experimental model during 10days. The aim of this study focuses on erythropoietin (EPO) receptor, GATA binding protein 1 (globin transcription factor 1) (GATA-1)...

journal_title：European journal of pharmacology

authors： Aguirre MV,Todaro JS,Juaristi JA,Brandan NC

更新日期：2010-06-25 00:00:00

abstract：:The effects of nimodipine on the amphetamine- and methamphetamine-induced decrease in central tryptophan hydroxylase activity was examined. Rats were administered 4 or 5 injections of amphetamine or methamphetamine at 6-h intervals with or without nimodipine (1 mg/kg), and killed 1 or 18 h after the last drug administ...

journal_title：European journal of pharmacology

authors： Elkins KW,Gibb JW,Hanson GR,Wilkins DG,Johnson M

更新日期：1993-12-21 00:00:00

abstract：:The binding of the bisquaternary muscarine receptor antagonist heptane-1,7-bis(dimethyl-3'-phthalimidopropyl)-ammonium bromide (C7/3-phth) was investigated at a number of cholinergic binding sites using (-)-[3H]nicotine, [3H]pirenzepine and (-)-[3H]quinuclidinyl benzilate ([3H]QNB) in both central and peripheral tissu...

journal_title：European journal of pharmacology

authors： Christopoulos A,Loiacono R,Mitchelson F

更新日期：1993-06-15 00:00:00

abstract：:Ethanol (160-640 mM) produces a biphasic action on the indirectly stimulated rat phrenic nerve--diaphragm preparation. This consists of a potentiation followed by a blockade of muscle contraction. Concomitant with the increase in the force of contraction was the appearance of multiple neural action potentials recorded...

journal_title：European journal of pharmacology

authors： Cooper SA,Dretchen KL

更新日期：1975-04-01 00:00:00

abstract：:The characteristics of histamine H1-receptors on astrocytes from the cerebral cortex of newborn rats in primary culture were analyzed with a [3H]mepyramine binding assay, and compared with those in the cerebral cortex. The apparent dissociation constant (KD) of [3H]mepyramine binding, the apparent inhibition constants...

journal_title：European journal of pharmacology

authors： Inagaki N,Fukui H,Taguchi Y,Wang NP,Yamatodani A,Wada H

更新日期：1989-11-28 00:00:00

abstract：:The aim of the present study was to further characterize [3H]clonidine binding in the ventrolateral medulla of the human brainstem, the region involved in the vasodepressor effect of imidazoline drugs of the clonidine type. Under basal conditions, [3H]clonidine can bind both to the imidazoline receptors and to the alp...

journal_title：European journal of pharmacology

authors： Bricca G,Greney H,Zhang J,Dontenwill M,Stutzmann J,Belcourt A,Bousquet P

更新日期：1994-01-01 00:00:00

abstract：:Paracetamol is one of the first rank drugs which cause hepatic damage during drug intoxications. Endothelin (ET) which is known as one of the most potent vasoactive agent has been shown to contribute in the pathophysiology of various diseases. We hypothesized that bosentan, which is a non-selective ET-1 receptor antag...

journal_title：European journal of pharmacology

authors： Yayla M,Halici Z,Unal B,Bayir Y,Akpinar E,Gocer F

更新日期：2014-03-05 00:00:00

abstract：:The antinociceptive effect of nitrous oxide (N(2)O) is dependent on nitric oxide (NO); however, the next step in the pathway activated by NO is undetermined. The present study was conducted to test the hypothesis that a N(2)O action involves sequential activation of NO synthase, soluble guanylyl cyclase and protein ki...

journal_title：European journal of pharmacology

authors： Zhang Y,Quock LP,Chung E,Ohgami Y,Quock RM

更新日期：2011-03-11 00:00:00

abstract：:Acute lung injury (ALI) is a common severe clinical syndrome in intensive care unit. Inflammation has been reported to play a critical role in the development of ALI. Cordycepin, an active component isolated from Cordyceps militaris, has been reported to have anti-inflammatory effects. However, the anti-inflammatory e...

journal_title：European journal of pharmacology

authors： Lei J,Wei Y,Song P,Li Y,Zhang T,Feng Q,Xu G

更新日期：2018-01-05 00:00:00

abstract：:We have previously shown that, in porcine aortic smooth muscle cells, endoplasmic reticulum (ER) stressor thapsigargin simultaneously activate the mitochondrial caspase-dependent death cascade and an extracellular signal-regulated kinase (ERK)-dependent pathway, which inhibits the caspase-independent death pathway. Ou...

journal_title：European journal of pharmacology

authors： Lin KC,Liu PS,Peng PY,Chueh SH

更新日期：2012-07-05 00:00:00

abstract：:Previous reports have shown that (+/-)-YM796 (2,8-dimethyl-3-methylene-1-oxa-8-azaspiro[4.5]decane) exhibits M1 agonistic activity and ameliorates cognitive impairment, and that the (-)-S isomer is active in in vitro studies. We report here the characterization of the (-)-S isomer, YM796 ((-)-(S)-2,8-dimethyl-3-methyl...

journal_title：European journal of pharmacology

authors： Wanibuchi F,Nishida T,Yamashita H,Hidaka K,Koshiya K,Tsukamoto S,Usuda S

更新日期：1994-11-24 00:00:00

abstract：:G(s)α is a ubiquitously expressed G protein α-subunit that couples receptors to the generation of intracellular cyclic AMP. The G(s)α gene GNAS is a complex gene that undergoes genomic imprinting, an epigenetic phenomenon that leads to differential expression from the two parental alleles. G(s)α is imprinted in a tiss...

journal_title：European journal of pharmacology

authors： Chen M,Nemechek NM,Mema E,Wang J,Weinstein LS

更新日期：2011-06-11 00:00:00

abstract：:Stretch-evoked ATP release from the bladder mucosa is a key event in signaling bladder fullness. Our aim was to examine whether acid and capsaicin can also release ATP and to determine the receptors involved, using agonists and antagonists at TRPV1 and acid-sensing ion channels (ASICs). Strips of porcine bladder mucos...

journal_title：European journal of pharmacology

authors： Sadananda P,Kao FC,Liu L,Mansfield KJ,Burcher E

更新日期：2012-05-15 00:00:00

abstract：:Macrophages play important roles in the healing and remodeling of cardiac tissues after myocardial ischemia/reperfusion (MI/R) injury. Here we investigated the potential effects of salvianolic acid B (SalB), one of the abundant and bioactive compounds extracted from Chinese herb Salvia Miltiorrhiza (Danshen), on macro...

journal_title：European journal of pharmacology

authors： Zhao M,Li F,Jian Y,Wang X,Yang H,Wang J,Su J,Lu X,Xi M,Wen A,Li J

更新日期：2020-03-15 00:00:00

abstract：:The involvement of peptidoleukotrienes (LTs) in mediating the increase in microvascular permeability associated with experimental cutaneous immediate hypersensitivity was studied by examining the effect of SK&F 104353, a potent and selective LT-antagonist, on the response evoked by graded, intradermal injections of an...

journal_title：European journal of pharmacology

authors： Woodward DF,Nieves AL,Williams LS,Gary RK Jr,Wasserman MA,Gleason JG

更新日期：1989-05-19 00:00:00

abstract：:The proenkephalin A derivative, peptide E, delayed gastrointestinal transit in mice and inhibited the micturition reflex in anesthetized rats after intracerebroventricular (i.c.v.) administration. BAM22P, BAM12P and [Met5]enkephalin, possible processing fragments of peptide E, were also compared in the two test system...

journal_title：European journal of pharmacology

authors： Davis TP,Porreca F,Burks TF,Dray A

更新日期：1985-05-08 00:00:00

abstract：:Ten beta-adrenoceptor blocking drugs varying in lipophilicity and beta-adrenoceptor blocking potency were examined for inhibitory effects on synaptosomal [3H]noradrenaline uptake. All compounds produced a concentration-dependent inhibition of noradrenaline uptake, but were at least one order of magnitude less potent t...

journal_title：European journal of pharmacology

authors： Street JA,Walsh A

更新日期：1984-07-13 00:00:00

abstract：:The neurochemical control of learning depends on several neurotransmitters, hormones, and neuropeptides. Cortistatin is a neuropeptide with sleep-modulating properties that regulates memory consolidation and evocation. Several reports have suggested that learning processes are expressed under diurnal variations; there...

journal_title：European journal of pharmacology

authors： Méndez-Díaz M,Irwin L,Gómez-Chavarín M,Jiménez-Anguiano A,Cabeza R,Murillo-Rodríguez E,Prospéro-García O

更新日期：2005-01-10 00:00:00

abstract：:The beta-antagonistic effects of celiprolol were assessed in isolated guinea-pig preparations. The pA2 values obtained were 7.84 +/- 0.07, 7.79 +/- 0.06 and 6.45 +/- 0.11 against the positive chronotropic and inotropic effects in the atria and relaxant effects in the trachea induced by isoproterenol, respectively, ind...

journal_title：European journal of pharmacology

authors： Ochi S,Nakazawa M,Kimura T,Nakagawa Y,Imai S

更新日期：1991-02-26 00:00:00

abstract：:In order to elucidate the signal transduction pathway of vascular smooth muscle contraction induced by the activation of receptors for angiotensin II and endothelin-1, we examined whether tyrosine kinases and mitogen-activated protein (MAP) kinases are involved in the development of force of contraction in the rat aor...

journal_title：European journal of pharmacology

authors： Ishihata A,Tasaki K,Katano Y

更新日期：2002-06-12 00:00:00

abstract：:We have investigated the endothelin receptor subtypes mediating contraction in isolated preparations of human saphenous vein. Endothelin-1 (EC50: 17.8 nM), endothelin-3 (EC50: 82.3 nM) and the endothelin ETB receptor-selective agonists, [Ala1,3,11,15]endothelin-1 (EC50: 63 nM) and sarafotoxin S6c (EC50: 0.75 nM) all p...

journal_title：European journal of pharmacology

authors： White DG,Garratt H,Mundin JW,Sumner MJ,Vallance PJ,Watts IS

更新日期：1994-05-23 00:00:00

abstract：:We hypothesized that uncompetitive NMDA glutamate receptor antagonists memantine (2,5-dimethyl-1-adamantanamine), and amino-alkyl-cyclohexane compounds: MRZ 2/579 (1-amino-1,3,3,5,5-pentamethylcyclohexane HCl), MRZ 2/600 (1-amino-1-ethyl-3,3,5,5-tetramethylcyclohexane HCl), and MRZ 2/615 (1-amino-1,3,5,5-tetramethyl-3...

journal_title：European journal of pharmacology

authors： Fourie J,Escobar MR,Sitar DS

更新日期：2002-09-27 00:00:00

abstract：:Cocaine and a cocaine analog, WIN 36,065-2, were administered daily for 3 or 4 days. Both compounds developed sensitization to their locomotor stimulatory effects, with similarly shaped dose-response curves. Dosages giving optimal sensitization were 25 mg/kg per day for cocaine and 3 mg/kg for WIN 35,065-2. At 40 mg/k...

journal_title：European journal of pharmacology

authors： Reith ME

更新日期：1986-10-14 00:00:00

abstract：:The effects of amiloride on contraction evoked by perivascular nerve stimulation were studied in a ring preparation of rat mesenteric artery. The contraction evoked by nerve stimulation was abolished by tetrodotoxin or prazosin. Amiloride depressed the nerve-induced contraction concentration dependently. Noradrenaline...

journal_title：European journal of pharmacology

authors： Shimamura K,Zou LB,Moriyama K,Yamamoto K,Sekiguchi F,Sunano S

更新日期：1997-02-05 00:00:00

abstract：:Characteristics of muscarinic receptors were investigated in circular muscle from normal human colon. In saturation studies (n=18), binding of [3H]quinuclidinyl benzylate (QNB) was of high affinity (K(d) 87.3 pM) and capacity (B(max) 362+/-27 fmol/mg protein), with no differences between ascending and sigmoid colon. K...

journal_title：European journal of pharmacology

authors： Mansfield KJ,Mitchelson FJ,Moore KH,Burcher E

更新日期：2003-12-15 00:00:00