Abstract:
:Using a batch method for incubation of hippocampal slices, we have examined the effects of 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (RU24969) and (m-trifluoromethylphenyl)piperazine (TFMPP) on release of endogenous 5-hydroxytryotamine (5-HT). Release of 5-HT from slices was enhanced by RU24969 and TFMPP at concentrations from 1 to 10 mumols. The 5-HT uptake inhibitors imipramine and fluoxetine, but not the autoreceptor antagonist methiothepin, blocked the enhancement in 5-HT. These results suggest that RU24969 and TFMPP, previously identified as potent agonists at the nerve terminal autoreceptor, also interact at higher concentrations with the reuptake carrier to enhance extracellular levels of 5-HT.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Auerbach SB,Kamalakannan N,Rutter JJdoi
10.1016/0014-2999(90)94111-asubject
Has Abstractpub_date
1990-11-06 00:00:00pages
51-7issue
1-2eissn
0014-2999issn
1879-0712pii
0014-2999(90)94111-Ajournal_volume
190pub_type
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