Desensitization and re-sensitization of CGRP receptor function in human neuroblastoma SK-N-MC cells.

abstract：:This study was designed to investigate the effects of serotonin on changes in intracellular Ca(2+) concentration ([Ca(2+)](i)) in cultured rat heart endothelial cells. Serotonin stimulated a biphasic change in cytosolic Ca(2+) of rat heart endothelial cells: an initial transient increase, which primarily reflects the ...

journal_title：European journal of pharmacology

authors： Lee HZ,Wu CH

更新日期：1999-11-12 00:00:00

abstract：:Treatment of rat reticulocytes with tetradecanoyl phorbol acetate (TPA), a tumor-promoting phorbol ester which activates protein kinase C, resulted in an about 50% decrease in the stimulation of adenylate cyclase activity by a subsequent challenge with a beta-adrenoceptor agonist. This phenomenon mimics agonist-induce...

journal_title：European journal of pharmacology

authors： Yamashita A,Kurokawa T,Une Y,Ishibashi S

更新日期：1988-07-07 00:00:00

abstract：:The purpose of our study was to examine whether a significant interaction occurs between NMDA and non-NMDA receptor antagonists on respiratory function. For this purpose chloralose-anesthetized cats were used and respiratory minute volume (VE), tidal volume (Vt) respiratory rate (f), inspiratory and expiratory duratio...

journal_title：European journal of pharmacology

authors： McManigle JE,Taveira DaSilva AM,Dretchen KL,Gillis RA

更新日期：1994-01-24 00:00:00

abstract：:The effects of a highly selective kappa antagonist, nor-binaltorphimine (nor-BNI), on the development of tolerance to morphine analgesia and physical dependence on morphine were examined. Pretreatment with nor-BNI (5 mg/kg s.c.) 2 h prior to injection of morphine or a selective kappa agonist, U-50,488H, significantly ...

journal_title：European journal of pharmacology

authors： Suzuki T,Narita M,Takahashi Y,Misawa M,Nagase H

更新日期：1992-03-17 00:00:00

abstract：:Intracellular Ca2+ overload induced by hypoxia-reoxygenation alters Ca2+ homeostasis, which plays an important role in myocardial cell injury. Even though propofol is known as a radical scavenger with Ca2+ channel blocking properties, little is known about cardioprotective effect associated with Ca2+ homeostasis in ca...

journal_title：European journal of pharmacology

authors： Kim HS,Chang WC,Hwang KC,Choi IG,Park WK

更新日期：2008-10-10 00:00:00

abstract：:The administration of radioactive angiotensin I to the retrogradely perfused feline adrenal gland caused a brisk discharge of catecholamines. Recovery of the labelled decapeptide and metabolites in the adrenal effluent fluid was complete in 5 min. Radioimmunoassay of this perfusate revealed that most of the peptide re...

journal_title：European journal of pharmacology

authors： Ackerly JA,Felger TS,Peach MJ

更新日期：1976-07-01 00:00:00

abstract：:Primary cultures of rat cerebellar granule neurons express 5-lipoxygenase, an enzyme from the inflammatory pathway of arachidonic acid. Outside the central nervous system (CNS) 5-lipoxygenase participates in cell proliferation. We hypothesized that 5-lipoxygenase is needed for proliferation of immature cerebellar gran...

journal_title：European journal of pharmacology

authors： Uz T,Manev R,Manev H

更新日期：2001-04-20 00:00:00

abstract：:Acanthoic acid, a pimaradiene diterpene isolated from Acanthopanax koreanum, has been reported to have anti-inflammatory activities. However, the effects of acanthoic acid on LPS-induced acute lung injury have not been reported. The purpose of this study was to investigate the protective effect of acanthoic acid on LP...

journal_title：European journal of pharmacology

authors： Qiushi W,Guanghua L,Guangquan X

更新日期：2015-03-05 00:00:00

abstract：:The binding of atrial natriuretic peptide (ANP) to olfactory bulb, pituitary anterior lobe and thymus gland membranes was examined. [125I]ANP (rat, 99-126) bound specifically to the three types of membranes. However, the affinity for ANP receptor in olfactory bulb was much higher than those in either pituitary or thym...

journal_title：European journal of pharmacology

authors： Agui T,Kurihara M,Saavedra JM

更新日期：1989-03-21 00:00:00

abstract：:Acute administration of fluoxetine (1, 10 and 20 mg/kg i.p.) increased extracellular levels of serotonin (5-hydroxytryptamine, 5-HT) in the frontal cortex, ventral hippocampus and raphe nuclei as measured by in vivo microdialysis in anaesthetized rats. In the frontal cortex, fluoxetine showed a marked dose-response ef...

journal_title：European journal of pharmacology

authors： Malagié I,Trillat AC,Jacquot C,Gardier AM

更新日期：1995-11-14 00:00:00

abstract：:Nitric oxide synthases (NOS) and cyclooxygenase-2 (COX-2) are important enzymes involved in ulcer healing but interactions between them have not been clearly defined. The aim of this study was to investigate the effects of selective or non-selective inhibition of NOS on the expression and activity of COX-2 during heal...

journal_title：European journal of pharmacology

authors： Guo JS,Cho CH,Wang JY,Koo MW

更新日期：2006-05-01 00:00:00

abstract：:Cordycepin, (3'-deoxyadenosine), a bioactive compound of Cordyceps militaris, has been shown to exhibit many pharmacological actions, such as anti-inflammatory, antioxidative and anticancer activities. Little is known about the neuroprotective action of cordycepin as well as its molecular mechanisms. In this study, co...

journal_title：European journal of pharmacology

authors： Cheng Z,He W,Zhou X,Lv Q,Xu X,Yang S,Zhao C,Guo L

更新日期：2011-08-16 00:00:00

abstract：:In WI-38 human fibroblasts, interleukin-1 beta and tumour necrosis factor-alpha (TNF-alpha) increased bradykinin B(1) receptor mRNA, which peaked between 2 and 4 h, remaining elevated for 20 h. Binding of the bradykinin B(1) receptor selective ligand [3H]des-Arg(10)-kallidin, also increased, peaking at 4 h and remaini...

journal_title：European journal of pharmacology

authors： Phagoo SB,Yaqoob M,Herrera-Martinez E,McIntyre P,Jones C,Burgess GM

更新日期：2000-06-02 00:00:00

abstract：:Recently, it has been suggested that bumetanide, an inhibitor of the Na-K-2Cl co-transporter (NKCC1), may be useful in the treatment of central nervous system (CNS) disorders. However, from a physicochemical perspective, bumetanide may not cross the blood-brain barrier to the extent that is necessary for it to be an e...

journal_title：European journal of pharmacology

authors： Donovan MD,Schellekens H,Boylan GB,Cryan JF,Griffin BT

更新日期：2016-01-05 00:00:00

abstract：:Preparations of cauda epididymides were taken from rats unilaterally vasectomised by medial transection of the vas deferens. Responses of preparations from the operated side to field stimulation (10 pulses, 70 V, 1 ms, 0.1-20 Hz) declined in parallel with decreases in catecholamine fluorescence. There were leftward sh...

journal_title：European journal of pharmacology

authors： Ventura S,DeGaris RM,Pennefather JN

更新日期：1989-12-19 00:00:00

abstract：:The effects of the new 3,4-disubstituted furoxan, CHF 2206, on vascular tone, platelet aggregation and platelet cyclic 3',5'-guanosine monophosphate (cGMP) levels were investigated. The compound was a potent inhibitor of rabbit aortic ring contraction induced by norepinephrine, the stable prostaglandin F2 alpha analog...

journal_title：European journal of pharmacology

authors： Civelli M,Caruso P,Giossi M,Bergamaschi M,Razzetti R,Bongrani S,Gasco A

更新日期：1994-04-01 00:00:00

abstract：:Chronic administration of amphetamine to cats (twice daily, in doses increasing from 5 to 15 mg/kg over a 10-day period) elicited a number of behaviors e.g., limb flicking, abortive grooming, and excessive head shaking, which were originally proposed as an animal behavioral model for studying the actions of hallucinog...

journal_title：European journal of pharmacology

authors： Trulson ME,Crisp T

更新日期：1984-04-06 00:00:00

abstract：:The 235-1 pituitary tumor clone was utilized to study prolactin secretion after perturbing cyclic AMP and calcium metabolism. Cellular cyclic AMP levels were elevated after treatment with PGE1, cholera toxin, forskolin, isobutylmethylxanthine as well as dibutryl cyclic AMP; these cyclic AMP responses were associated w...

journal_title：European journal of pharmacology

authors： Schettini G,Rogol AD,MacLeod RM,Yasumoto T,Cronin MJ

更新日期：1985-03-12 00:00:00

abstract：:The present study investigated whether there is any difference between the effects of benzodiazepine and non-benzodiazepine anxiolytics on maternal aggression in lactating mice, using an ethological technique. We used SM-3997, a 5-HT1A receptor ligand, as a non-benzodiazepine anxiolytic. Behavior towards an intruder m...

journal_title：European journal of pharmacology

authors： Yoshimura H,Ogawa N

更新日期：1991-07-23 00:00:00

abstract：:In anesthetized, artificially ventilated guinea pigs immunized against ovalbumin, challenge with aerosolized ovalbumin (0.1 mg) elicited a substantial and sustained increase of insufflation pressure. The inhibitor of endogenous nitric oxide (NO) synthesis, L-NAME (N omega-nitro-L-arginine methylester, 30 mg kg-1 i.v.)...

journal_title：European journal of pharmacology

authors： Persson MG,Friberg SG,Hedqvist P,Gustafsson LE

更新日期：1993-11-16 00:00:00

abstract：:The ligand preferences of recombinant NR1 homomeric and NR1-NR2 heteromeric NMDA receptors were examined by homogenate binding assay. The binding affinities for most ligands were similar to those reported for native NMDA receptors. The order of affinity for [3H]glutamate was NR1-NR2B > NR1-NR2A approximately NR1-NR2D ...

journal_title：European journal of pharmacology

authors： Laurie DJ,Seeburg PH

更新日期：1994-08-16 00:00:00

abstract：:[3H]MDL 105,519 (((E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1[3H]-indole-2-ca rboxylic acid) is a novel radioligand which binds with high affinity, Kd = 2.5 nM, to the glycine site of adult rodent forebrain, N-methyl-D-aspartate subtype of glutamate receptors. As with other glycine site antagonists, the major det...

journal_title：European journal of pharmacology

authors： Chazot PL,Reiss C,Chopra B,Stephenson FA

更新日期：1998-07-17 00:00:00

abstract：:An 125I-iodinated ryanodine analog, modified by attaching an iodo-Cbz-beta-alanyl group to the C10eq hydroxy of ryanodine (iodo-carbobenzyloxy-beta-alanyl-ryanodine), binds to cardiac sarcoplasmic reticulum Ca2+ release channels with equal affinity as [3H]ryanodine. In the present study, both iodo-Cbz-beta-alanyl-ryan...

journal_title：European journal of pharmacology

authors： Bowling N,Mais DE,Gerzon K,Watanabe AM

更新日期：1994-08-16 00:00:00

abstract：:In pithed rats, we studied the effects of prostaglandin E2 and of subtype-selective prostaglandin E receptor (EP receptor) ligands on the rise in blood pressure induced by electrical stimulation of the preganglionic sympathetic nerves. Prostaglandin E2, the EP1/EP3 receptor agonist sulprostone and the EP2/EP3 receptor...

journal_title：European journal of pharmacology

authors： Malinowska B,Godlewski G,Buczko W,Schlicker E

更新日期：1994-07-11 00:00:00

abstract：:Current clinical options for the treatment of neovascular disorders of the posterior segment of the eye have several drawbacks. Photocoagulation lasers can impair peripheral and night vision. Photodynamic therapies as well as intravitreal macromolecule injections (Macugen and Lucentis) require frequent, invasive admin...

journal_title：European journal of pharmacology

authors： Raghava S,Kompella UB

更新日期：2007-07-30 00:00:00

abstract：:The effects of a potent non-steroidal antiinflammatory drug, indomethacin, on the inflammatory response and lymphocyte proliferation were investigated in adjuvant-arthritic rats. As shown by others, adjuvant produced a time-dependent swelling of the contralateral paw which was maximal within 14 days after administrati...

journal_title：European journal of pharmacology

authors： Seng GF,Benensohn J,Bayer BM

更新日期：1990-03-27 00:00:00

abstract：:The convulsant, anticonvulsant and anaesthetic activities of a series of 6 barbiturates related to pentobarbitone have been qualitatively and quantitatively determined in mice. The presence or absence of convulsant activity was strongly dependent on molecular structure and there were marked variations in potency among...

journal_title：European journal of pharmacology

authors： Andrews PR,Jones GP,Poulton DB

更新日期：1982-04-08 00:00:00

abstract：:Stearoyl-CoA Desaturase 1 (SCD1) is a central enzyme that catalyzes the biosynthesis of monounsaturated fatty acids from saturated fatty acids. SCD1 is an emerging target in obesity and insulin resistance due to the improved metabolic profile obtained when the enzyme is genetically inactivated. Here, we have investiga...

journal_title：European journal of pharmacology

authors： Issandou M,Bouillot A,Brusq JM,Forest MC,Grillot D,Guillard R,Martin S,Michiels C,Sulpice T,Daugan A

更新日期：2009-09-15 00:00:00

abstract：:We used in vitro autoradiography to identify the endothelin-1 receptor subtype(s) in the superficial gray layer of the superior colliculus of rats. These studies showed dense binding of (3-[125I]iodotyrosyl13)-[Ala11,15]Ac-endothelin-1-(6-2 1) (BQ3020) (for endothelin ETB receptors), while tissues incubated with [125I...

journal_title：European journal of pharmacology

authors： D'Amico M,Di Filippo C,Rossi F

更新日期：1998-04-17 00:00:00

abstract：:We examined the effects of intrarenal infusion of EXP3174, a non-peptide angiotensin II receptor antagonist, in order to evaluate the physiological role of endogenous angiotensin II in regulating renal hemodynamics and urine formation and to assess the possibility of a tubular site(s) of action of endogenous angiotens...

journal_title：European journal of pharmacology

authors： Tamaki T,Nishiyama A,Yoshida H,He H,Fukui T,Yamamoto A,Aki Y,Kimura S,Iwao H,Miyatake A

更新日期：1993-05-12 00:00:00