Ryanodine and an iodinated analog: doxorubicin effects on binding and Ca2+ accumulation in cardiac sarcoplasmic reticulum.

abstract：:The mode of protection against cardiac reperfusion injury by mild hypothermia and TRO40303 was investigated in various experimental models and compared to MitoQ in vitro. In isolated cardiomyocytes subjected to hypoxia/reoxygenation, TRO40303, MitoQ and mild hypothermia delayed mPTP opening, inhibited generation of mi...

journal_title：European journal of pharmacology

authors： Hansson MJ,Llwyd O,Morin D,de Paulis D,Arnoux T,Gouarné C,Koul S,Engblom H,Bordet T,Tissier R,Arheden H,Erlinge D,Halestrap AP,Berdeaux A,Pruss RM,Schaller S

更新日期：2015-08-05 00:00:00

abstract：:The aim of this study was to investigate the contribution of the Na(+)/H(+) exchanger to cerebral ischemia using SM-20220 (N-(aminoiminomethyl)-1-methyl-1H-indole-2-carboxamide methanesulfonate), a newly synthesized compound. In in vitro experiments, we evaluated the inhibitory effect of SM-20220 on the Na(+)/H(+) exc...

journal_title：European journal of pharmacology

authors： Kuribayashi Y,Itoh N,Kitano M,Ohashi N

更新日期：1999-10-27 00:00:00

abstract：:The cellular localisation and distribution of mRNAs encoding beta-adrenoceptor subtypes in human lung were studied by in situ hybridisation and Northern blot analysis. The 851-bp SmaI/PvuII fragment of human beta 1-adrenoceptor cDNA, the 439-bp SmaI fragment of human beta 2-adrenoceptor cDNA and the 975-bp SmaI fragme...

journal_title：European journal of pharmacology

authors： Mak JC,Nishikawa M,Haddad EB,Kwon OJ,Hirst SJ,Twort CH,Barnes PJ

更新日期：1996-04-29 00:00:00

abstract：:Failed medical therapy is a common problem in inflammatory bowel disease. P-glycoprotein (P-gp), an efflux pump encoded by MDR1 (ABCB1) gene can actively pump drugs out of cells conferring the phenotype of multidrug resistance. Various studies evoked that cyclooxygenase (COX) system may be involved in the regulation o...

journal_title：European journal of pharmacology

authors： Zrieki A,Farinotti R,Buyse M

更新日期：2010-06-25 00:00:00

abstract：:Sensitization to the discriminative stimulus effects of psychostimulants is not fully understood. Therefore, the present study was designed to investigate the development of sensitization to the discriminative stimulus of methamphetamine in rats. A dose-response curve for methamphetamine and a generalization test for ...

journal_title：European journal of pharmacology

authors： Suzuki T,Fukuoka Y,Mori T,Miyatake M,Narita M

更新日期：2004-09-13 00:00:00

abstract：:The effects of histamine H(1) receptor antagonists (promethazine, diphenhydramine, chlorphenilamine and triprolidine) on hippocampal theta rhythm during eight-arm radial maze performance were investigated using rats. Promethazine showed a significant increase in the number of total errors and working memory errors at ...

journal_title：European journal of pharmacology

authors： Masuoka T,Mikami A,Yasuda M,Shinomiya K,Kamei C

更新日期：2007-12-08 00:00:00

abstract：:Cocaine dependence continues to be a worldwide public health concern. Although the majority of individuals reporting cocaine use do so via the intranasal route, relatively few laboratory experiments have examined the reinforcing effects of cocaine administered intranasally. The purpose of this experiment was to measur...

journal_title：European journal of pharmacology

authors： Stoops WW,Lile JA,Glaser PE,Hays LR,Rush CR

更新日期：2010-10-10 00:00:00

abstract：:The bisquaternary compound dequalinium has been tested for its ability to inhibit the loss of K+ which angiotensin II causes in guinea-pig hepatocytes and which occurs through apamin-sensitive Ca(2+)-activated K+ (SKCa) channels. Dequalinium blocked angiotensin II-evoked K+ loss with an IC50 of 1.5 +/- 0.1 microM and ...

journal_title：European journal of pharmacology

authors： Castle NA,Haylett DG,Morgan JM,Jenkinson DH

更新日期：1993-05-19 00:00:00

abstract：:Plasma concentrations of unchanged dihydroergotamine (DHE) were measured in beagle dogs on days 1 and 7 of a 1 week treatment with daily oral doses of DHE. Responses to both 5-HT and noradrenaline were monitored isometrically on spiral strips from saphenous arteries and femoral veins removed 24 and 72 h after the last...

journal_title：European journal of pharmacology

authors： Müller-Schweinitzer E,Rosenthaler J

更新日期：1983-04-22 00:00:00

abstract：:After prolonged stimulation, the delta-opioid receptor becomes desensitized by regulatory mechanisms such as receptor phosphorylation, internalization and down-regulation. In this study, we demonstrate that morphine treatment causes phosphorylation of S363 in the C-terminus of the human delta-opioid receptor. Morphine...

journal_title：European journal of pharmacology

authors： Navratilova E,Eaton MC,Stropova D,Varga EV,Vanderah TW,Roeske WR,Yamamura HI

更新日期：2005-09-20 00:00:00

abstract：:The binding of [3H]LSD to serotonergic sites in human brain was studied. The pharmacological profile of [3H]LSD binding in frontal cortex differed to that in hippocampus. Analysis of the inhibition of [3H]LSD binding by serotonin and spiperone was consistent with the presence of two binding sites, which differed in ph...

journal_title：European journal of pharmacology

authors： Cross AJ

更新日期：1982-08-13 00:00:00

abstract：:Endothelial dysfunction ensuing inhibition of nitric oxide synthase (NOS) was investigated in male Sprague-Dawley rats given N(omega)-nitro-L-arginine methyl ester (L-NAME) in drinking water for 8 weeks. Age-matched rats served as controls. L-NAME-treated rats, as compared to control animals, showed: (1) a clear-cut i...

journal_title：European journal of pharmacology

authors： De Gennaro Colonna V,Rossoni G,Rigamonti A,Bonomo S,Manfredi B,Berti F,Muller E

更新日期：2002-08-16 00:00:00

abstract：:The antagonist effects of ketanserin and 2'-methyl-4'-(5-methyl-1,2,4)oxadiazol-3-yl)-biphenyl-[4-carboxyli c acid 4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide (GR 127,935) were compared to naratriptan-induced inhibition of cAMP formation in C6-glial cell lines stably expressing human 5-HT1D or 5-HT1B receptor ...

journal_title：European journal of pharmacology

authors： Pauwels PJ,Colpaert FC

更新日期：1996-04-04 00:00:00

abstract：:Exposure of cultured heart muscle cells to noradrenaline led to a decrease in the effects of isoproterenol and prostaglandin E1 on cAMP formation and contraction velocity. However, heterologous desensitization, as measured by prostaglandin E1 stimulation, only occurred at higher noradrenaline concentrations than homol...

journal_title：European journal of pharmacology

authors： Reithmann C,Werdan K

更新日期：1988-09-01 00:00:00

abstract：:We have eliminated putative palmitoylation sites in the carboxyl tail of the human dopamine D1 receptor by replacing the two cysteine residues with alanines either separately or together. The wild type and the three mutated dopamine D1 receptors were stably expressed in baby hamster kidney cells and characterized to d...

journal_title：European journal of pharmacology

authors： Jin H,Zastawny R,George SR,O'Dowd BF

更新日期：1997-04-11 00:00:00

abstract：:Effects of the 5-HT3 receptor agonist, m-chlorophenylbiguanide (10.0-40.0 microg), on sleep and waking were studied in control, vehicle-treated and 6-hydroxydopamine-injected rats. Bilateral injections of m-chlorophenylbiguanide into the nucleus accumbens of the control and the vehicle-infused animals significantly in...

journal_title：European journal of pharmacology

authors： Monti JM,Ponzoni A,Jantos H,Lagos P,Silveira R,Banchero P

更新日期：1999-01-08 00:00:00

abstract：:The aim was to determine whether blockade of store-operated Ca(2+) entry, or inhibition of Ca(2+) sensitisation, is the predominant mechanism by which neuronally released nitric oxide mediates relaxation of the mouse anococcygeus. Nitrergic relaxations to field stimulation (10 Hz, 10 s trains) were unaffected by the s...

journal_title：European journal of pharmacology

authors： Gibson A,Wallace P,McFadzean I

更新日期：2003-06-27 00:00:00

abstract：:Right ventricular kitten papillary muscles were incubated with dibutyryl adenosine 3',5'-monophosphate (dbcAMP) at varying concentrations as low as 1 X 10(-4)M. A positive inotropic effect was observed with all concentrations of dbcAMP. Concomitant administration of 5 X 10(-4)M monobutyryl guanosine 3',5'-monophosphat...

journal_title：European journal of pharmacology

authors： Wilkerson RD,Paddock RJ,George WJ

更新日期：1976-03-01 00:00:00

abstract：:Alpha(2A)-Adrenoceptors mediate the antinociceptive effects of alpha(2)-adrenoceptor agonists in mice, and analgesic synergism between noradrenergic and opioidergic mechanisms has been reported to be lacking in mice devoid of functional alpha(2A)-adrenoceptors. We investigated whether the antinociceptive actions of op...

journal_title：European journal of pharmacology

authors： Ozdoğan UK,Lähdesmäki J,Scheinin M

更新日期：2006-01-04 00:00:00

abstract：:In WI-38 human fibroblasts, interleukin-1 beta and tumour necrosis factor-alpha (TNF-alpha) increased bradykinin B(1) receptor mRNA, which peaked between 2 and 4 h, remaining elevated for 20 h. Binding of the bradykinin B(1) receptor selective ligand [3H]des-Arg(10)-kallidin, also increased, peaking at 4 h and remaini...

journal_title：European journal of pharmacology

authors： Phagoo SB,Yaqoob M,Herrera-Martinez E,McIntyre P,Jones C,Burgess GM

更新日期：2000-06-02 00:00:00

abstract：:In normotensive rats, we have previously demonstrated a role of brain mineralocorticoid receptors in blood pressure and renal function control. In the present study, the coordinate cardiovascular and renal effects of brain mineralocorticoid receptor blockade were examined by intracerebroventricular (i.c.v.) administra...

journal_title：European journal of pharmacology

authors： Rahmouni K,Sibug RM,De Kloet ER,Barthelmebs M,Grima M,Imbs JL,De Jong W

更新日期：2002-02-02 00:00:00

abstract：:Inhibition of local cortisol regeneration from circulating cortisone by blocking 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) has been shown to ameliorate the risk factors associated with the metabolic syndrome. Chronic modulation of glucocorticoid homeostasis may result in hypothalamic-pituitary-adrenal (HPA) axis s...

journal_title：European journal of pharmacology

authors： Hamilton BS,Schoelch C,Schuler-Metz A,Krosky P,Lala DS,Claremon DA,McGeehan GM

更新日期：2016-10-15 00:00:00

abstract：:Effects of N-ethylmaleimide or forskolin on electrically evoked dopamine release were investigated in striatal slices of rats pretreated with methamphetamine. N-Ethylmaleimide and forskolin both enhanced the evoked dopamine release in a concentration-dependent manner. The enhancement by N-ethylmaleimide of spontaneous...

journal_title：European journal of pharmacology

authors： Yamada S,Yokoo H,Nishi S

更新日期：1994-05-23 00:00:00

abstract：:The effects of escins Ib and IIb isolated from horse chestnuts on Mg(2+) absorption from the digestive tract and the role of endogenous nitric oxide (NO) were investigated in mice. Test samples were given orally to fasted mice 30, 120, 180, 240 and 300 min before administration of 0.5 M MgSO(4) (10 ml/kg, p.o.). The s...

journal_title：European journal of pharmacology

authors： Li Y,Matsuda H,Wen S,Yamahara J,Yoshikawa M

更新日期：2000-01-17 00:00:00

abstract：:Changrolin (2, 6-bis[pyrrolidin-1-ylmethyl]-4-[quinazolin-4-ylamino] phenol) is an anti-arrhythmic drug derived from β-dichroine, an active component of the Chinese medicinal herb, Dichroa febrifuga Lour. To elucidate the mechanism underlying the anti-arrhythmic effect of changrolin, we used the whole-cell patch-clamp...

journal_title：European journal of pharmacology

authors： Chen WH,Yang D,Wang WY,Zhang J,Wang YP

更新日期：2010-11-25 00:00:00

abstract：:The responses of spinothalamic, spinoreticular, and unidentified spinal neurons to intracardiac administration of phenylbiguanide, a 5-HT3 receptor agonist, were examined in anesthetized cats and monkeys. Eighteen neurons were excited, 5 were inhibited, and 12 were unresponsive to this stimulus. Results suggest that c...

journal_title：European journal of pharmacology

authors： Blair RW,Chandler MJ,Bolser DC,Foreman RD

更新日期：1992-05-27 00:00:00

abstract：:The affinity of LY-171555 (quinpirole) and BHT-920 for both states of rat striatal dopamine D-1 and D-2 receptors was determined. Although these drugs have different pharmacological effects in experimental animals, we found that they had similar affinities for both D-1 and D-2 receptors. ...

journal_title：European journal of pharmacology

authors： Ferré S,Guix T,Sallés J,Cuffí L,Badia A,Casas M

更新日期：1989-07-18 00:00:00

abstract：:Gerbils trained to respond differentially to the presence or absence of diazepam (8.0 mg/kg) in a T-maze showed a dose-related antagonism when challenged with bemegride (5.0-40.0 mg/kg). Gerbils trained with a mixture of diazepam (8.0 mg/kg) and bemegride (20.0 mg/kg) evidenced response control more slowly than the gr...

journal_title：European journal of pharmacology

authors： Johansson JO,Järbe TU

更新日期：1975-02-01 00:00:00

abstract：:The i.c.v. administration of 0.5 microgram pertussis toxin to mice led to a non-competitive reduction (approximately 60 to 70%) of the supraspinal analgesia evoked by i.c.v. injection of ED90 doses of [D-Ala2,N-MePhe4,Gly-ol5]enkephalin, [D-Ala2,N-MePhe4,Met-(O)5-ol]enkephalin, [D-Ala2,Met5]enkephalinamide, [D-Ala2,D-...

journal_title：European journal of pharmacology

authors： Sánchez-Blázquez P,Garzón J

更新日期：1988-08-02 00:00:00

abstract：:Recent studies have suggested that hydrogen sulfide (H2S), an important endogenous signaling gaseous molecule, participates in relaxation of smooth muscle. Nevertheless, the mechanism of this relaxation effect on respiratory system is still unclear. The present study aims to investigate the physiological function as w...

journal_title：European journal of pharmacology

authors： Huang J,Luo YL,Hao Y,Zhang YL,Chen PX,Xu JW,Chen MH,Luo YF,Zhong NS,Xu J,Zhou WL

更新日期：2014-10-15 00:00:00