当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Increase of glucocorticoids is not required for the acquisition, but hinders the extinction, of lithium-induced conditioned taste aversion.

Increase of glucocorticoids is not required for the acquisition, but hinders the extinction, of lithium-induced conditioned taste aversion.

Abstract：

:Lithium chloride at doses sufficient to induce conditioned taste aversion (CTA) causes c-Fos expression in the paraventricular nucleus and increases the plasma level of corticosterone with activation of the hypothalamic-pituitary-adrenal axis. This study was conducted to define the role of glucocorticoid in the acquisition and extinction of lithium-induced CTA. In experiment 1, Sprague-Dawley rats received dexamethasone (2mg/kg) or RU486 (20mg/kg) immediately after 5% sucrose access, and then an intraperitoneal injection of isotonic lithium chloride (12ml/kg) was followed with 30min interval. Rats had either 1 or 7 days of recovery period before the daily sucrose drinking tests. In experiment 2, rats were conditioned with the sucrose-lithium pairing, and then received dexamethasone or vehicle at 30min before each drinking test. In experiment 3, adrenalectomized (ADX or ADX+B) rats were subjected to sucrose drinking tests after the sucrose-lithium pairing. Dexamethasone, but not RU486, pretreatment blunted the formation of lithium-induced CTA memory. Dexamethasone prior to each drinking test suppressed sucrose consumption and prolonged the extinction of lithium-induced CTA. Sucrose consumption was significantly suppressed not only in ADX+B rats but also in ADX rats during the first drinking session; however, a significant decrease was found only in ADX rats on the fourth drinking session. These results reveal that glucocorticoid is not a necessary component in the acquisition, but an important player in the extinction, of lithium-induced CTA, and suggest that a pulse increase of glucocorticoid may hinder the extinction memory formation of lithium-induced CTA.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Kim KN,Kim BT,Kim YS,Lee JH,Jahng JW

doi

10.1016/j.ejphar.2014.02.017

subject

Has Abstract

pub_date

2014-05-05 00:00:00

pages

14-9

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(14)00146-0

journal_volume

730

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF PHARMACOLOGY文献大全
  • Atypical characteristics of frog and chick erythrocyte beta-adrenoceptors.

    abstract：:The characteristics of beta-adrenoceptors on frog and chick erythrocytes have been compared to those present on rat erythrocyte, lung and cerebral cortical membranes. The receptors have been examined using the specific ligand [3H]dihydroalprenolol ([3H]DHA) with conventional filtration techniques. The equilibrium diss...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(81)90321-6

    authors： Dickinson KE,Nahorski SR

    更新日期：1981-08-27 00:00:00

  • The effect of gamma-acetylenic GABA, an enzyme-activated irreversible inhibitor of GABA-transaminase, on dopamine pathways of the extrapyramidal and limbic systems.

    abstract：:gamma-Acetylenic GABA (100 mg/kg i.p.) inhibited GABA-transaminase activity and caused a several-fold increase in the concentration of GABA in rat brain. This increased GABA concentration was associated with a decreased rate of dopamine depletion following alpha-methyl-p-tyrosine treatment and a decrease in homovanill...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(78)90138-3

    authors： Palfreyman MG,Huot S,Lippert B,Schechter PJ

    更新日期：1978-08-15 00:00:00

  • MDIMP, a novel cardiac Ca(2+) channel blocker with atrial selectivity.

    abstract：:In cardiac muscle cells both T-and L-type Ca(2+) channels (TTCCs and LTCCs, respectively) are expressed, and the latter are relevant to a process known as excitation-contraction coupling (ECC). Evidence obtained from docking studies suggests that isoindolines derived from α-amino acids bind to the LTCC CaV1.2. In the ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2016.04.027

    authors： Santamaria-Herrera MA,Ríos-Pérez EB,de la Rosa JA,García-Castañeda M,Osornio-Garduño DS,Ramos-Mondragón R,Mancilla-Percino T,Avila G

    更新日期：2016-06-15 00:00:00

  • Possible involvement of Ca(2+)-induced Ca2+ release mechanism in Ag(+)-induced contracture in frog skeletal muscle.

    abstract：:To determine if an Ag(+)-induced contracture is associated with the Ca(2+)-induced Ca2+ release mechanism in the sarcoplasmic reticulum, effects of Ca(2+)-induced Ca2+ release modulators on the Ag(+)-induced contracture were studied with single fibers of frog toe skeletal muscle. The fiber treated with 1 mM caffeine c...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0926-6917(95)90036-5

    authors： Oba T,Nihonyanagi K,Yamaguchi M

    更新日期：1995-03-16 00:00:00

  • Involvement of dopamine in the mechanism of action of FR64822, a novel non-opioid antinociceptive compound.

    abstract：:A novel compound, FR64822(N-(4-pyridylcarbamoyl)amino 1,2,3,6,-tetrahydropyridine), displays antinociceptive activities in a variety of assays with mice and rats. It has a strong antinociceptive activity in the acetic acid writhing test (ED50 = 1.8 mg/kg p.o.), whereas it has little antinociceptive activity in the tai...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(91)90695-m

    authors： Ohkubo Y,Nomura K,Yamaguchi I

    更新日期：1991-11-05 00:00:00

  • Inhibition of soluble epoxide hydrolase attenuates airway remodeling in a chronic asthma model.

    abstract：:Airway remodeling in asthma is difficult to treat because of its complex pathophysiology that involves proinflammatory cytokines, as well as the arachidonic acid cytochrome P-450 (CYP) pathway; however, it has received little attention. In this study, we assessed the efficacy of a soluble epoxide hydrolase (sEH) on ai...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2019.172874

    authors： Jiang JX,Guan Y,Shen HJ,Jia YL,Shen J,Zhang LH,Liu Q,Zhu YL,Xie QM

    更新日期：2020-02-05 00:00:00

  • Beneficial effect of pharmacological mobilization of bone marrow in experimental cerebral ischemia.

    abstract：:Bone marrow stem cells are able to differentiate into nervous and endothelial cells. In our study, we found that administration of a bone marrow-stimulating factor (granulocyte colony-stimulating factor; G-CSF 50 microg/kg) decrease the brain infarct volume and enhance survival rate in a model of cerebral ischemia. Ta...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(02)02785-1

    authors： Six I,Gasan G,Mura E,Bordet R

    更新日期：2003-01-05 00:00:00

  • Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model.

    abstract：:Closed head injury induces cerebral oxidative stress. The efficacy of a Mn (III) porphyrin catalytic antioxidant was assessed in a mouse closed head injury model. Mice were subjected to closed head injury and treated 15 min later with an i.v. bolus of vehicle or 3 mg/kg MnTE-2-PyP5+. Aconitase activity, Fluoro-Jade st...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2005.12.031

    authors： Leinenweber SB,Sheng H,Lynch JR,Wang H,Batinić-Haberle I,Laskowitz DT,Crapo JD,Pearlstein RD,Warner DS

    更新日期：2006-02-15 00:00:00

  • Differences between rats and mice in MDMA (methylenedioxymethylamphetamine) neurotoxicity.

    abstract：:In both rats and mice a single large dose of methylenedioxymethylamphetamine (MDMA; 25 mg/kg i.p.) caused a fall 3 h after injection in the content of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in cortex, a fall in noradrenaline in hippocampus and cerebellum, and a rise in dopamine (DA) but fal...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(88)90717-0

    authors： Logan BJ,Laverty R,Sanderson WD,Yee YB

    更新日期：1988-08-02 00:00:00

  • Combination of OK432 and human interferon-alpha for treating viral-induced diabetes mellitus in mice.

    abstract：:We investigated the therapeutic effects of OK432 (picibanil; CAS39325-1-4), an immunomodulator that is derived from the Su strain of Streptococcus pyogenes. This agent was administered alone or combined with human interferon-alpha in a murine model of insulin-dependent diabetes mellitus. Interferon-alpha inhibits vira...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)01476-3

    authors： Kanda T,Kogure S,Nara M,Tsukui S,Utsugi T,Tomono S,Kawazu S,Nagai R,Kobayashi I

    更新日期：1998-01-26 00:00:00

  • [125I]iodoclonazepam, a specific high affinity radioligand for the identification of BZ1 and BZ2 sites in rat brain.

    abstract：:Binding of the radioligand [125I]iodoclonazepam to three different areas of rat brain (cerebellum, hippocampus and striatum) has been characterised. In all three regions binding is rapid, saturable and of high affinity (cerebellum Bmax = 1.49 +/- 0.3 pmol/mg of protein, Kd = 0.39 +/- 0.06 nM; hippocampus Bmax = 1.5 +/...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(91)90484-8

    authors： Gillard NP,Quirk K,Ragan CI,McKernan RM

    更新日期：1991-04-03 00:00:00

  • A single dose of benzodiazepine hypnotics alters the sleep EEG in the subsequent drug-free night.

    abstract：:All-night spectral analysis of the sleep EEG was used to study the effect and after-effect of a single bedtime dose of flunitrazepam (2 mg), flurazepam (30 mg) or triazolam (0.5 mg) in healthy young males. In the night of drug treatment all 3 hypnotics reduced the EEG slow waves and enhanced the activity in the freque...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(83)90622-2

    authors： Borbély AA,Mattmann P,Loepfe M,Fellmann I,Gerne M,Strauch I,Lehmann D

    更新日期：1983-04-22 00:00:00

  • In vitro studies with ICI 169,369, a chemically novel 5-HT antagonist.

    abstract：:ICI 169,369 is a chemically novel 5-HT antagonist that has higher affinity for the 5-HT2 binding sites in rat cortex than it has for 5-HT1 sites (Ki 1.79 x 10(-8) and 1.58 x 10(-6) M, respectively). In isolated tissue preparations ICI 169,369 was shown to be a competitive antagonist of 5-HT on the rabbit aorta, pig co...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(88)90005-2

    authors： Blackburn TP,Thornber CW,Pearce RJ,Cox B

    更新日期：1988-06-10 00:00:00

  • Astragaloside IV attenuates Toll-like receptor 4 expression via NF-κB pathway under high glucose condition in mesenchymal stem cells.

    abstract：:Diabetic hyperglycemia causes a variety of pathological changes. Astragaloside IV (AS-IV) was widely used for the treatment of cardiovascular diseases in China. The aim of this study was to determine the effect of AS-IV on bone marrow mesenchymal stem cells (MSCs) and the underlying mechanism in diabetes. We used reve...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2012.09.033

    authors： Li M,Yu L,She T,Gan Y,Liu F,Hu Z,Chen Y,Li S,Xia H

    更新日期：2012-12-05 00:00:00

  • Stimulation of kappa-opioid receptor reduces isoprenaline-induced cardiac hypertrophy and fibrosis.

    abstract：:The aim of the present study was to determine whether U50,488H (a selective kappa-opioid receptor agonist) inhibits cardiac hypertrophy and fibrosis induced by beta-adrenoceptor stimulation in a rat model. Cardiac hypertrophy and fibrosis were developed by intraperitoneal administration of isoprenaline (ip. 3.0 mg/kg/...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2009.01.050

    authors： Yin W,Zhang P,Huang JH,Zhang QY,Fan R,Li J,Zhou JJ,Hu YZ,Guo HT,Zhang SM,Wang YM,Kaye AD,Gu CH,Liu JC,Cheng L,Cui Q,Yi DH,Pei JM

    更新日期：2009-04-01 00:00:00

  • Beta-endorphin differentially affects inflammation in two inbred rat strains.

    abstract：:It has been shown that inflammation of rat paws elicits accumulation of opioid peptide beta-endorphin-containing immune cells in the inflamed subcutaneous tissue, contributing to immunocyte-produced pain suppression. However, the possible mechanisms involved in the pharmacological application of beta-endorphin in rat ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2006.08.012

    authors： Stanojević S,Mitić K,Vujić V,Kovacević-Jovanović V,Dimitrijević M

    更新日期：2006-11-07 00:00:00

  • Role of tachykinin NK3 receptors in the release and effects of nerve growth factor in human isolated bronchi.

    abstract：:The nerve growth factor (NGF) is a neurotrophic factor essential for the development and survival of neurons. It has also been identified as a mediator of inflammation and can cause airway hyperresponsiveness [Frossard et al., Eur. J. Pharmacol. 500, 453 (2004)]. Evidence in rodents suggests a link between tachykinins...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2006.10.068

    authors： Naline E,Höglund CO,Vincent F,Emonds-Alt X,Lagente V,Advenier C,Frossard N

    更新日期：2007-04-10 00:00:00

  • 12-Deoxyphorbol 13-palmitate mediated cell growth inhibition, G2-M cell cycle arrest and apoptosis in BGC823 cells.

    abstract：:The highly toxic monomer 12-deoxyphorbol 13-palmitate (G) was extracted from the roots of Euphorbia fischeriana. Our experimental data confirmed studies showing that 12-deoxyphorbol 13-palmitate had certain antitumor activities. The MTT method, soft agar experiments, and nude mouse tumor experiments proved that 12-deo...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2012.11.015

    authors： Xu HY,Chen ZW,Li H,Zhou L,Liu F,Lv YY,Liu JC

    更新日期：2013-01-30 00:00:00

  • Tachykinin receptors in the guinea-pig isolated bronchi.

    abstract：:The aim of the study was to assess which tachykinin receptors mediate the contractile response in the guinea-pig isolated bronchi. Experiments with natural tachykinins and receptor-selective tachykinin agonists were performed in the absence or presence of peptidase inhibitors and in bronchi pretreated with phenoxybenz...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(91)90517-t

    authors： Maggi CA,Patacchini R,Quartara L,Rovero P,Santicioli P

    更新日期：1991-05-17 00:00:00

  • Cardioprotection of salidroside from ischemia/reperfusion injury by increasing N-acetylglucosamine linkage to cellular proteins.

    abstract：:The modification of proteins with O-linked N-acetylglucosamine (O-GlcNAc) is increasingly recognized as an important posttranslational modification that modulates cellular function. Recent studies suggested that augmentation of O-GlcNAc levels increase cell survival following stress. Salidroside, one of the active com...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2009.04.012

    authors： Wu T,Zhou H,Jin Z,Bi S,Yang X,Yi D,Liu W

    更新日期：2009-06-24 00:00:00

  • Effects of oxidized low-density lipoprotein on differentiation of mouse neural progenitor cells into neural cells.

    abstract：:In Alzheimer's disease (AD), a decline in function of neural progenitor cells (NPCs) results in a reduced capacity for neural regeneration. It has been shown that plasma oxidized low-density lipoprotein (ox-LDL) levels are positively correlated with severity in patients with AD. However, the direct effects of ox-LDL o...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2020.173456

    authors： Ishizuka T,Nagata W,Nomura-Takahashi S,Satoh Y

    更新日期：2020-12-05 00:00:00

  • Effects of prenatal co-administration of phentermine and dexfenfluramine in rats.

    abstract：:Pregnant rats were infused with phentermine plus dexfenfluramine from days 3 through 17 of gestation. Control rats were either pair-fed or were fed ad libitum. There were no effects of prenatal drug treatment on number of offspring, their birth weights, or on their motor coordination assessed at 11 days of age. Mother...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(99)00100-4

    authors： Bratter J,Gessner IH,Rowland NE

    更新日期：1999-03-26 00:00:00

  • Human urotensin II mediates vasoconstriction via an increase in inositol phosphates.

    abstract：:The cyclic peptide urotensin II has recently been cloned from human and reported to potently constrict primate blood vessels. To elucidate the cellular signalling mechanisms of this peptide, we investigated a possible relationship of vasomotor effects of human urotensin II and phosphoinositide turnover in isolated rab...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(00)00672-5

    authors： Saetrum Opgaard O,Nothacker H,Ehlert FJ,Krause DN

    更新日期：2000-10-13 00:00:00

  • Acetylcholinesterase-independent action of diisopropyl-flurophosphate in the rat aorta.

    abstract：:Recent studies have shown that many organophosphates can bind competitively and noncompetitively to membrane muscarinic receptors. The present study investigated the responses of the rat aortic rings to diisopropyl-flurophosphate (DFP), an organophsophorus cholinesterase inhibitor, and the possible involvement of musc...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(00)00629-4

    authors： Lim SL,Sim MK,Loke WK

    更新日期：2000-09-22 00:00:00

  • Hydrophilic residues at position 3 highlight unforeseen features of the fMLP receptor pocket.

    abstract：:The peptides for-Met-Leu-Tyr-OMe, for-Met-Leu-Glu-OMe, for-Met-Leu-Asp-OMe and for-Met-Leu-Ser-OMe were synthesized to investigate the importance of a hydrophilic side chain of the residue at position 3 on biological activities of human neutrophils. A number of in vitro essays were carried out, including: chemotaxis, ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(03)01672-8

    authors： Spisani S,Turchetti M,Varani K,Falzarano S,Cavicchioni G

    更新日期：2003-05-23 00:00:00

  • The regulation of mitochondrial respiration by opening of mKCa channels is age-dependent.

    abstract：:The protective potency of ischemic preconditioning decreases with increasing age. A key step in ischemic preconditioning is the opening of mitochondrial Ca(2+) sensitive K(+) (mK(Ca)) channels, which causes mild uncoupling of mitochondrial respiration. We hypothesized that aging reduces the effects of mK(Ca) channel o...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2007.09.008

    authors： Heinen A,Winning A,Schlack W,Hollmann MW,Preckel B,Frässdorf J,Weber NC

    更新日期：2008-01-14 00:00:00

  • Enkephalin release and opioid receptor activation does not mediate the antinociceptive or sedative/hypnotic effects of nitrous oxide.

    abstract：:In previous studies using Fos expression as a marker of neuronal activation, we showed that nitrous oxide (N(2)O) activates bulbospinal noradrenergic neurons in rats and that destruction of these neuronal pathways leads to loss of N(2)O antinociceptive action. Based on previous rat studies it has been proposed that th...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(01)01193-1

    authors： Kingery WS,Sawamura S,Agashe GS,Davies MF,Clark JD,Zimmer A

    更新日期：2001-09-07 00:00:00

  • Muscarinic receptor subtypes in the human colon: lack of evidence for atypical subtypes.

    abstract：:Characteristics of muscarinic receptors were investigated in circular muscle from normal human colon. In saturation studies (n=18), binding of [3H]quinuclidinyl benzylate (QNB) was of high affinity (K(d) 87.3 pM) and capacity (B(max) 362+/-27 fmol/mg protein), with no differences between ascending and sigmoid colon. K...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2003.10.008

    authors： Mansfield KJ,Mitchelson FJ,Moore KH,Burcher E

    更新日期：2003-12-15 00:00:00

  • Distinct roles of diverse nuclear factor-kappaB complexes in neuropathological mechanisms.

    abstract：:The nuclear transcription factors kappaB (NF-kappaB) function as key regulators of physiological processes in the central nervous system. Aberrant regulation of NF-kappaB can underlie neurological disorders associated with neurodegeneration. A large number of studies have reported a dual role of NF-kappaB in regulatin...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejphar.2006.06.027

    authors： Pizzi M,Spano P

    更新日期：2006-09-01 00:00:00

  • In vitro binding of the very potent and selective D-2 dopamine agonist, [3H]N-0437 to calf caudate membranes.

    abstract：:N-0437, a non-catecholic aminotetralin has recently been described as a very potent and selective dopamine D-2 agonist. In this study the in vitro binding of [3H]N-0437 (specific activity 80.6 Ci/mmol) to calf caudate membranes is described. It was found that [3H]N-0437 binds with a high affinity (KD = 0.17 nM) and a ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(87)90167-1

    authors： Van der Weide J,De Vries JB,Tepper PG,Horn AS

    更新日期：1987-02-10 00:00:00