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Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model.

Abstract：

:Closed head injury induces cerebral oxidative stress. The efficacy of a Mn (III) porphyrin catalytic antioxidant was assessed in a mouse closed head injury model. Mice were subjected to closed head injury and treated 15 min later with an i.v. bolus of vehicle or 3 mg/kg MnTE-2-PyP5+. Aconitase activity, Fluoro-Jade staining, glial fibrillary acidic protein immunoreactivity, and rotarod falling latencies were measured. Closed head injury altered all variables. MnTE-2-PyP5+ had no effect on any variable with the exception of attenuation of aconitase inactivation at 2 h post-closed head injury. In a second experiment, mice received 3 mg/kg or 6 mg/kg MnTE-2-PyP5+ or vehicle i.v. 15 min post-closed head injury. Rotarod and Morris water maze latencies were measured. Closed head injury altered performance in both tests. No statistically significant effect of MnTE-2-PyP5+ was observed. We conclude that single dose MnTE-2-PyP5+ does not alter outcome in this mouse closed head injury model.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Leinenweber SB,Sheng H,Lynch JR,Wang H,Batinić-Haberle I,Laskowitz DT,Crapo JD,Pearlstein RD,Warner DS

doi

10.1016/j.ejphar.2005.12.031

keywords:

subject

Has Abstract

pub_date

2006-02-15 00:00:00

pages

126-32

issue

1-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(05)01336-1

journal_volume

531

pub_type

杂志文章

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