Effects of CS-518, a thromboxane synthase inhibitor, on eosinophil function.

abstract：:Drug addiction shares brain mechanisms and molecular substrates with learning and memory processes, such as the stimulation of glutamate receptors and their downstream signalling pathways. In the present work we provide an up-to-date review of studies that have demonstrated the implication of the main memory-related c...

journal_title：European journal of pharmacology

authors： García-Pardo MP,Roger-Sanchez C,Rodríguez-Arias M,Miñarro J,Aguilar MA

更新日期：2016-06-15 00:00:00

abstract：:The anti-inflammatory activity of avarol and avarone, sesquiterpenoid derivatives from the Mediterranean sponge Dysidea avara, was investigated. Both compounds potently inhibited paw oedema induced by carrageenan (approximated ED50 = 9.2 and 4.6 mg/kg, p.o., respectively) as well as ear oedema induced by 12-O-tetradec...

journal_title：European journal of pharmacology

authors： Ferrándiz ML,Sanz MJ,Bustos G,Payá M,Alcaraz MJ,De Rosa S

更新日期：1994-02-21 00:00:00

abstract：:Mitochondria are major compartments in cells responsible for generating reactive oxygen species, which can cause the development of diabetes, Parkinson's disease and premature aging. Antioxidant systems in mitochondria are important for the prevention of diseases and reduction in the speed of aging. We investigated wh...

journal_title：European journal of pharmacology

authors： Kadota Y,Suzuki S,Ideta S,Fukinbara Y,Kawakami T,Imai H,Nakagawa Y,Sato M

更新日期：2010-01-25 00:00:00

abstract：:[3H]Spiroperidol binding was used to assay dopaminergic receptors in synaptosomal membranes isolated from basal ganglia of cat brain. In addition to the usual filtration, a special centrifugation technique was developed which has some advantages for ligands with high non-specific binding. The specific binding to contr...

journal_title：European journal of pharmacology

authors： Jimenez Aguilar C,De Robertis E

更新日期：1982-04-08 00:00:00

abstract：:The effect of the kappa-opioid receptor agonist, bremazocine, on plasma oxytocin levels in rats was measured by a sensitive radioimmunoassay. Initially, a decrease in plasma oxytocin levels was seen 30 min after injection. This was in accordance with the bremazocine inhibition of oxytocin release after submaximal elec...

journal_title：European journal of pharmacology

authors： Grell S,Fjalland B,Christensen JD

更新日期：1989-07-04 00:00:00

abstract：:SCH 23390 (R(+)-7-chloro-8-hydroxy-2,3,4,5-tetrahydro-3-methyl-1-phenyl-1H-3 -benzazepine) is a potent, relatively selective antagonist of the D-1 dopamine receptor ( Iorio et al., J. Pharmacol. Exp. Ther. 226, 462). Because SKF 75670, the 7-OH analogue of SCH 23390, is a partial D-1 agonist, we conclude that the 7-Cl...

journal_title：European journal of pharmacology

authors： Itoh Y,Beaulieu M,Kebabian JW

更新日期：1984-04-13 00:00:00

abstract：:Excessive intracellular accumulation of zinc (Zn(2+)) is neurotoxic and contributes to a number of neuropathological conditions. Here, we investigated the protective effect of 3-morpholinosydnonimine (SIN-1) against Zn(2+)-induced neuronal cell death in differentiated PC12 cells. We found that Zn(2+)-induced PC12 cell...

journal_title：European journal of pharmacology

authors： An JM,Moon SA,Hong SY,Kang JW,Seo JT

更新日期：2015-02-05 00:00:00

abstract：:Rings of canine bronchi were suspended for isometric tension recording. Contractions produced by exogenously added acetylcholine were inhibited by pirenzepine and pancuronium. The pKB values were 6.76 for pirenzepine (calculated at 10(-6) M) and 5.30 and 5.13 for pancuronium (calculated at 10(-5) and 3 X 10(-5) M, res...

journal_title：European journal of pharmacology

authors： O'Rourke ST,Flavahan NA,Vanhoutte PM

更新日期：1987-08-04 00:00:00

abstract：:Pharmacological properties of oxime reactivators, not related to its ability to regenerate or reactivate nerve agent-inhibited acetylcholinesterase located at nerve synapses, have been reported to be important in protecting against poisoning by the nerve agent soman. Such non-reactivation effects have thus far been as...

journal_title：European journal of pharmacology

authors： Loke WK,Sim MK,Go ML

更新日期：2005-10-03 00:00:00

abstract：:The locations of the vascular resistance sites which regulate vascular tone in the hepatic arterial and portal venous vasculatures of the rat liver were identified using a new, in vitro, dual-perfused liver preparation. Twelve livers of male Wistar rats were perfused via the hepatic artery and portal vein at fixed flo...

journal_title：European journal of pharmacology

authors： Yang W,Benjamin IS,Alexander B

更新日期：1999-01-01 00:00:00

abstract：:Although cyclosporine A (CsA) is a potent immunomodulating agent and is commonly used as a systemic agent for the management of psoriasis patients, current clinical treatments are not always effective due to the clinical inefficacy of low-doses and numerous harmful effects of higher doses. Currently, the combined use ...

journal_title：European journal of pharmacology

authors： Kim CH,Kim JY,Lee AY

更新日期：2015-06-05 00:00:00

abstract：:Parenterally administered substance P suppressed stress-induced eating (resulting from mild tail pinch) in a dose-related manner, whereas at similar or higher doses of substance P starvation-induced eating was uneffected. This specific effect of substance P on stress-induced eating is possibly associated with alterati...

journal_title：European journal of pharmacology

authors： Morley JE,Levine AS

更新日期：1980-10-17 00:00:00

abstract：:The effects of MP 518, an acylated 2-chlorobenzylidene hydrazidone derivative with antihypertensive properties were investigated on the Ca current, ICa, recorded under whole-cell patch-clamp in single frog ventricular cells. MP 518 (1-100 microM) had no effect on ICa under control conditions. However, at 10 microM it ...

journal_title：European journal of pharmacology

authors： Scamps F,Tran G,Rinjard P,Binet P,Miocque M,Vassort G

更新日期：1993-01-15 00:00:00

abstract：:The significance of neuropeptide Y Y(2) receptors in sympathetic nonadrenergic transmission was investigated using the novel selective antagonist BIIE0246 ((S)-N2-[[1-[2-[4-[(R,S)-5,11-dihydro-6(6h)-oxodibenz[b,e]azepin-11-yl]-1-piperazinyl]-2-oxoethyl]cyclopentyl]acetyl]-N-[2-[1,2-dihydro-3,5 (4H)-dioxo-1,2-diphenyl-...

journal_title：European journal of pharmacology

authors： Malmström RE,Lundberg JO,Weitzberg E

更新日期：2002-03-29 00:00:00

abstract：:Slices of rat kidney cortex were incubated in [3H]noradrenaline, then placed in a flow cell and subjected to electrical field stimulation. At a stimulation frequency of 5 Hz, both the alpha 2-adrenoceptor antagonist idazoxan (0.1 microM) and the alpha 1-adrenoceptor antagonist prazosin (0.1 microM) significantly enhan...

journal_title：European journal of pharmacology

authors： Murphy TV,Majewski H

更新日期：1989-10-10 00:00:00

abstract：:Berberine, which is a major constituent of the rhizome of Coptidis japonica (CJ), inhibits IL-8 production in colonic epithelial cells and improves 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice. In our preliminary studies, berberine inhibited lipid peroxidation in liposomes prepared from l-α-phosp...

journal_title：European journal of pharmacology

authors： Lee IA,Hyun YJ,Kim DH

更新日期：2010-12-01 00:00:00

abstract：:Synthesized pyridine compound derivatives (SK94, SK126) from a natural lead source were administered to mice to test for possible anti-TNF alpha and anti-inflammatory activities. Lipopolysaccharide (LPS)-induced TNF alpha production was analyzed in the endothelial cells, Raw 264.7 cells, and serum of normal mice after...

journal_title：European journal of pharmacology

authors： Choi B,Kim J,Lee ES,Bang D,Sohn S

更新日期：2011-04-25 00:00:00

abstract：:Antipsychotic drugs are traditionally classified as typical or atypical on the basis of their property to cause or not to cause extrapyramidal side-effects. A widely accepted selectivity for the mesolimbic, vs. the nigrostriatal, dopaminergic system is postulated to underlie the existence of fewer or no extrapyramidal...

journal_title：European journal of pharmacology

authors： Melis M,Gessa GL,Diana M

更新日期：1998-12-18 00:00:00

abstract：:The localization of natriuretic peptide receptors was studied in LLC-PK1 cell monolayers grown on a micro-porous membrane filter. The addition of alpha-human atrial natriuretic peptide (alpha-hANP) to the apical side of the cells produced a concentration-dependent increase in cyclic GMP (cGMP) formation, the extent of...

journal_title：European journal of pharmacology

authors： Hashimoto Y,Ozaki J,Yasuhara M,Hori R,Suga S,Itoh H,Nakao K,Inui K

更新日期：1994-08-16 00:00:00

abstract：:Endothelins, 21-amino acid peptides involved in the pathogenesis of various diseases, bind to endothelin ET(A) and ET(B) receptors to initiate their effects. Here, we characterize the pharmacology of A-216546 ([2S-(2,2-dimethylpentyl)-4S-(7-methoxy-1,3-benzodioxol-5-yl )-1-(N,N-di(n-butyl) aminocarbonylmethyl)-pyrroli...

journal_title：European journal of pharmacology

authors： Wu-Wong JR,Dixon DB,Chiou WJ,Dayton BD,Novosad EI,Adler AL,Wessale JL,Calzadilla SV,Hernandez L,Marsh KC,Liu G,Szczepankiewicz B,von Geldern TW,Opgenorth TJ

更新日期：1999-02-05 00:00:00

abstract：:Bitter taste receptors (Tas2rs) initiate a bitter taste signaling involving the activation of taste-specific G protein gustducin and phosphodiesterases (PDEs); it leads to the decrease of cytosolic level of cyclic adenosine monophosphate (cAMP) in taste cells. Recent studies have identified the expression of Tas2rs in...

journal_title：European journal of pharmacology

authors： Liu M,Qian W,Subramaniyam S,Liu S,Xin W

更新日期：2020-04-05 00:00:00

abstract：:The involvement of a central mechanism in the antiemetic effect of AS-8112 ((R)-5-bromo-N-(1-ethyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-2-methoxy-6-methylamino-3-pyridinecarboxamide x 2 fumarate), a novel and potent dopamine D2, D3, and 5-HT(3) receptor antagonist, was investigated in ferrets. Intracerebroventricul...

journal_title：European journal of pharmacology

authors： Yoshikawa T,Yoshida N,Oka M

更新日期：2001-11-23 00:00:00

abstract：:The effects of gentamicin, an aminoglycoside antibiotic, on changes in the catecholamine levels in the rat striatum, hypothalamus, adrenal medulla and vas deferens were studied. When rats were i.v. injected with gentamicin (1.0 mg/kg), the catecholamine content of all tissues increased 2-4 h after injection. The incre...

journal_title：European journal of pharmacology

authors： Mikami M,Tachikawa E,Kashimoto T

更新日期：1992-01-07 00:00:00

abstract：:In the present work we evaluated the anticonvulsant effects of two novel antagonists of the glycine co-agonist site (glycineB receptor) within the N-methyl-D-aspartate (NMDA) receptor complex, MRZ 2/576 (a tricyclic pyrido-phtalazin dione derivative) and L-701,324 (7-chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(H)quinoline)...

journal_title：European journal of pharmacology

authors： Wlaź P,Löscher W

更新日期：1998-01-19 00:00:00

abstract：:The anti-ulcer activity of calcitonin gene-related peptide (CGRP) was inhibited, in a dose-dependent manner, by pretreatment with NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase. Our results suggest that endogenous nitric oxide is involved in the anti-ulcer activity of CGRP. ...

journal_title：European journal of pharmacology

authors： Clementi G,Caruso A,Prato A,De Bernardis E,Fiore CE,Amico-Roxas M

更新日期：1994-04-21 00:00:00

abstract：:Pleurisy was induced in rats by an intrapleural injection of 0.5 ml of 1% kaolin. The exudation of plasma into the pleural cavity showed two peaks at 20 min and 3-5 h after the kaolin injection. The volume of the pleural fluid increased gradually up to 5 h. The effects of treatment with mepyramine, methysergide, capto...

journal_title：European journal of pharmacology

authors： Hori Y,Jyoyama H,Yamada K,Takagi M,Hirose K,Katori M

更新日期：1988-08-02 00:00:00

abstract：:The present work is aimed at evaluating the protective effect of eugenol against in vitro nicotine-induced toxicity in murine peritoneal macrophages, compared with N-acetylcysteine. Eugenol was isolated from Ocimum gratissimum and characterized by HPLC, FTIR, (1)H NMR. To establish most effective protective support, w...

journal_title：European journal of pharmacology

authors： Kar Mahapatra S,Chakraborty SP,Majumdar S,Bag BG,Roy S

更新日期：2009-11-25 00:00:00

abstract：:In the present study we examined the effect of the cannabinoid receptor agonist, [[1 a,2-(R)-5-(1,1-dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyc lohexyl]-phenol; CP 55,940] on [14C]acetylcholine and [3H]norepinephrine release from hippocampal slices and on [14C]acetylcholine release from striatal slices. CP 55,...

journal_title：European journal of pharmacology

authors： Gifford AN,Samiian L,Gatley SJ,Ashby CR Jr

更新日期：1997-04-18 00:00:00

abstract：:The effect of the anti-allergic drug azelastine, 4-(p-chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepine-4-yl)-1-(2H)-phth alazione), on airway hyperresponsiveness induced by immunologically stimulated pulmonary alveolar macrophages was investigated in canine bronchial segments under isometric conditions in vitro. Macroph...

journal_title：European journal of pharmacology

authors： Tamaoki J,Takemura H,Tagaya E,Sakai A,Yamawaki I,Konno K

更新日期：1995-05-15 00:00:00

abstract：:In mice with acute dextran sulfate sodium colitis, we examined the effect of inducible nitric oxide synthase inhibition by (1S,5S,6R,7R)-7chloro-3-amino-5methyl-2-azabicyclo[4.1.0]heptane hydrochloride (ONO-1714) on colonic biochemistry, injury, and inflammation. Colonic luminal nitrate and nitrite were measured by th...

journal_title：European journal of pharmacology

authors： Naito Y,Takagi T,Ishikawa T,Handa O,Matsumoto N,Yagi N,Matsuyama K,Yoshida N,Yoshikawa T

更新日期：2001-01-19 00:00:00