Effect of azelastine on airway hyperresponsiveness mediated by stimulated macrophages.

abstract：:The effects of intracerebroventricular (i.c.v.), intravenous (i.v.) and oral (p.o.) administration of trimebutine on the gastric motor inhibition induced by acoustic stress were investigated in fasted dogs fitted with strain-gauge transducers on the antrum and proximal jejunum. Started 40-50 min after the last migrati...

journal_title：European journal of pharmacology

authors： Gué M,Pascaud X,Hondé C,Junien JL,Buéno L

更新日期：1988-01-27 00:00:00

abstract：:Right ventricular papillary muscles of the guinea-pig heart were electrically stimulated. Cromakalim 10-100 microM and Ro 31-6930 3 microM depressed the contractile force and shortened the duration of action potentials. Glibenclamide 0.3-3 microM, ATP 100 microM and alpha, beta-methylene ATP (alpha, beta-meATP) 30 mic...

journal_title：European journal of pharmacology

authors： Bott A,Eltze M,Illes P

更新日期：1992-03-17 00:00:00

abstract：:I.v. administration of McN-2378 appeared to preferentially increase cerebral blood flow as opposed to systemic (femoral) blood flow in two strains of monkeys. This cerebral vasodilation was not affected by theta-adrenergic blockade. In the anesthetized dog, the compound transiently lowered systemic arterial pressure w...

journal_title：European journal of pharmacology

authors： Hageman WE,Pruss TP

更新日期：1975-01-01 00:00:00

abstract：:The cellular localisation and distribution of mRNAs encoding beta-adrenoceptor subtypes in human lung were studied by in situ hybridisation and Northern blot analysis. The 851-bp SmaI/PvuII fragment of human beta 1-adrenoceptor cDNA, the 439-bp SmaI fragment of human beta 2-adrenoceptor cDNA and the 975-bp SmaI fragme...

journal_title：European journal of pharmacology

authors： Mak JC,Nishikawa M,Haddad EB,Kwon OJ,Hirst SJ,Twort CH,Barnes PJ

更新日期：1996-04-29 00:00:00

abstract：:Lipoprotein lipase (LPL) is the rate-controlling enzyme for the accumulation of triacylglycerol into adipocytes, which acts by digesting it into glycerol and fatty acids. In this study, we found that treatment with (+)-JQ1, an inhibitor of the bromodomain and extra-terminal (BET) family proteins, for 4 days from the e...

journal_title：European journal of pharmacology

authors： Inoue T,Hariya N,Imamochi Y,Dey A,Ozato K,Goda T,Kubota T,Mochizuki K

更新日期：2019-09-05 00:00:00

abstract：:Duration of heart rate corrected QT interval (QTc) is a crucial and critical factor in the assessment of repolarization changes considering safety of drugs and cardiac disorders. In rats, a validated approach to QT correction is lacking. In this study, we tested the normalization of QTc using normalization factor acco...

journal_title：European journal of pharmacology

authors： Kmecova J,Klimas J

更新日期：2010-09-01 00:00:00

abstract：:A brain slice preparation was used to examine the effects of galanin on the spontaneous firing rate of locus coeruleus noradrenergic neurons. Galanin (10(-9)-10(-7) M), added to the bath, inhibited the firing of 14 out of 19 neurons in a concentration-dependent manner. The observed effect was quite variable, ranging f...

journal_title：European journal of pharmacology

authors： Seutin V,Verbanck P,Massotte L,Dresse A

更新日期：1989-05-19 00:00:00

abstract：:The objective of the present studies was to investigate the effect of voluntary ethanol consumption for 21 days on the brain beta-endorphin system of C57BL/6 (alcohol-preferring) and DBA/2 (alcohol-avoiding) strains of mice. As expected, C57BL/6 mice consumed a significantly higher quantity of the 10% ethanol solution...

journal_title：European journal of pharmacology

authors： De Waele JP,Gianoulakis C

更新日期：1994-06-02 00:00:00

abstract：:The purpose of this study was to investigate whether the selective angiotensin AT2 receptor ligands, CGP 42112B (Nic-Tyr-(N alpha-benzoyloxycarbonyl-Arg)Lys-His-Pro-Ile-OH) and PD 123319 ((s)-1-[[4-(dimethylamino)-3-methyl-phenyl]methyl]-5-(diphenylacetyl+ ++)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]-pyridine-6-carboxylic...

journal_title：European journal of pharmacology

authors： Macari D,Whitebread S,Cumin F,De Gasparo M,Levens N

更新日期：1994-06-23 00:00:00

abstract：:This study investigates the possible protective effects of levocetirizine against fructose-induced insulin resistance, hepatic steatosis and vascular dysfunction, in comparison to pioglitazone, a standard insulin sensitizer. Male Sprague Dawley rats (150-200 g) were divided into 4 groups. Three groups were fed on high...

journal_title：European journal of pharmacology

authors： Shawky NM,Shehatou GS,Abdel Rahim M,Suddek GM,Gameil NM

更新日期：2014-10-05 00:00:00

abstract：:Rats isolated at 16--18 days of age showed after 10--12 months a complex behavioural syndrome in which locomotor activity was markedly increased when compared to that of group-housed controls. The hyperactivity of the socially deprived animals was selectively blocked by clinically effective antidepressants but not by ...

journal_title：European journal of pharmacology

authors： Garzón J,Fuentes JA,Del Rio J

更新日期：1979-11-16 00:00:00

abstract：:In type 1 diabetes, there is a rapid loss of glycemic control immediately after onset of the disease. We aimed to determine if the deterioration of glycemic control that occurs early after the onset of insulin-deficient diabetes could be blunted by treatment with recombinant fibroblast growth factor 21 (FGF21). Normal...

journal_title：European journal of pharmacology

authors： Andersen B,Omar BA,Rakipovski G,Raun K,Ahrén B

更新日期：2015-10-05 00:00:00

abstract：:Tracazolate (ICI 136,753) 4-butylamine-1-ethyl-6-methyl-1H-pyrazolo[3,4]pyridine-5-carboxylic acid ethyl ester is a non-benzodiazepine with anxiolytic-like activity in animal models. In contrast to the benzodiazepines, it enhances [3H]flunitrazepam binding in rat synaptic membrane fragments. The enhancement is potenti...

journal_title：European journal of pharmacology

authors： Meiners BA,Salama AI

更新日期：1982-03-12 00:00:00

abstract：:The release of endogenous aspartic acid (Asp), glutamic acid (Glu) and gamma-aminobutyric acid (GABA) was investigated in synaptosomes prepared from various regions of the rat brain. The basal release of Asp, Glu and GABA from various regions was 12-35, 24-107 and 15-43 pmol/min per mg protein, respectively. Exposure ...

journal_title：European journal of pharmacology

authors： Kamisaki Y,Hamahashi T,Hamada T,Maeda K,Itoh T

更新日期：1992-06-24 00:00:00

abstract：:The potency and site of action of Ro5-3663 as a GABA antagonist were investigated in the rat cuneate slice in vitro. A Schild plot for Ro5-3663 was clearly non-linear but enabled a pA2 value of 3.97 to be calculated. Combination studies using the 'classical' GABA antagonists bicuculline and picrotoxin indicated that R...

journal_title：European journal of pharmacology

authors： Harrison NL,Simmonds MA

更新日期：1983-01-28 00:00:00

abstract：:α1-Adrenoceptor stimulation of mouse aorta causes intracellular Ca(2+) release from sarcoplasmic reticulum Ca(2+) stores via stimulation of inositoltriphosphate (IP3) receptors. It is hypothesized that this Ca(2+) release from the contractile and IP3-sensitive Ca(2+) store is under the continuous dynamic control of ti...

journal_title：European journal of pharmacology

authors： Leloup AJ,Van Hove CE,De Meyer GR,Schrijvers DM,Fransen P

更新日期：2015-08-05 00:00:00

abstract：:The effects of an inhibitor of calmodulin, trifluoperazine (TFP), were determined on the electrical activity of cultured cell reaggregates derived from chick embryonic hearts (15-day-old). The cells exhibited naturally occurring slowly rising action potentials (APs) having a maximum rate of rise (+Vmax) of less than 3...

journal_title：European journal of pharmacology

authors： Bkaily G,Sperelakis N,Eldefrawi M

更新日期：1984-10-01 00:00:00

abstract：:Pulmonary arterial remodeling is a crucial cause of increased pulmonary artery pressure during pulmonary hypertension (PH). Recently, growing evidence has upheld the contribution of endothelial-mesenchymal transition (EndMT) to pulmonary arterial remodeling, but the underlying mechanisms remain largely unaddressed. mi...

journal_title：European journal of pharmacology

authors： Liu T,Zou XZ,Huang N,Ge XY,Yao MZ,Liu H,Zhang Z,Hu CP

更新日期：2019-11-15 00:00:00

abstract：:The effect of somatostatin (SRIF) on VIP induction of SRIF secretion, cyclic AMP accumulation and 45Ca2+ influx was investigated in cultured diencephalic cells. [D-Trp8]SRIF suppressed VIP-stimulated SRIF release and decreased VIP-stimulated cyclic AMP accumulation in a dose-dependent manner. SRIF-14 blocked basal and...

journal_title：European journal of pharmacology

authors： Pares-Herbute N,Diaz J,Astier H,Tapia-Arancibia L

更新日期：1989-02-28 00:00:00

abstract：:The effects of chronic continuous and intermittent administration of the dopamine D1 receptor agonist SKF 38393 or the D2 receptor agonist quinpirole on rotational behavior and dopamine receptor binding were examined in rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal pathway. Continuous and interm...

journal_title：European journal of pharmacology

authors： Engber TM,Marin C,Susel Z,Chase TN

更新日期：1993-06-04 00:00:00

abstract：:Antiarrhythmic drugs have been considered to be transported by the organic cation transport system. The purpose of this study was to elucidate the molecular mechanism underlying the transport of antiarrhythmic drugs using cells from the second segment of the proximal tubule (S2) cells of mice expressing human-organic ...

journal_title：European journal of pharmacology

authors： Hasannejad H,Takeda M,Narikawa S,Huang XL,Enomoto A,Taki K,Niwa T,Jung SH,Onozato ML,Tojo A,Endou H

更新日期：2004-09-19 00:00:00

abstract：:The treatment of rat thymocytes with 10 microM terfenadine resulted in a significant increase in DNA fragmentation. The DNA fragmentation induced by terfenadine was dependent on its concentration and incubation time. In terfenadine-treated cells, the translocation of phosphatidylserine from the inside of plasma membra...

journal_title：European journal of pharmacology

authors： Enomoto R,Komai T,Yoshida Y,Sugahara C,Kawaguchi E,Okazaki K,Kinoshita H,Komatsu H,Konishi Y,Lee E

更新日期：2004-08-02 00:00:00

abstract：:Cannabinoid CB(2) receptor is reported to be expressed in varying amounts in different human immune subpopulations. To examine the expression pattern of CB(2) in the mouse, immune cell subpopulations were purified and studied by semiquantitative Reverse Transcription-Polymerase Chain Reaction (RT-PCR). CB(2) mRNA was ...

journal_title：European journal of pharmacology

authors： Lee SF,Newton C,Widen R,Friedman H,Klein TW

更新日期：2001-07-06 00:00:00

abstract：:The pharmacological profile of a novel and newly discovered non-steroidal anti-inflammatory and analgesic compound, 3-(difluoromethyl)-1-(4-methoxyphenyl)-5-[4-(methylsulfinyl)phenyl]pyraz ole (FR140423), was investigated. In recombinant human cyclooxygenase enzyme assays, the inhibition of prostaglandin E2 formation ...

journal_title：European journal of pharmacology

authors： Ochi T,Jobo-Magari K,Yonezawa A,Matsumori K,Fujii T

更新日期：1999-01-22 00:00:00

abstract：:The peptides for-Met-Leu-Tyr-OMe, for-Met-Leu-Glu-OMe, for-Met-Leu-Asp-OMe and for-Met-Leu-Ser-OMe were synthesized to investigate the importance of a hydrophilic side chain of the residue at position 3 on biological activities of human neutrophils. A number of in vitro essays were carried out, including: chemotaxis, ...

journal_title：European journal of pharmacology

authors： Spisani S,Turchetti M,Varani K,Falzarano S,Cavicchioni G

更新日期：2003-05-23 00:00:00

abstract：:Three membrane preparations of rat cortex were used to examine the effects of GABA, bicuculline and bicucine on specific 3H-diazepam binding. In the crude synaptosomal fraction, GABA had no effect on either the maximal binding capacity (Bmax) or dissociation constant (KD) of 3H-diazepam binding. Bicuculline and bicuci...

journal_title：European journal of pharmacology

authors： Chiu TH,Rosenberg HC

更新日期：1979-07-01 00:00:00

abstract：:The effect of the non-selective antagonist of excitatory amino acid receptors kynurenic acid (50, 100 and 150 mg/kg, i.p.) on morphine-derived reward was studied in rats. Kynurenic acid dose dependently blocked the acquisition of morphine conditioned place preference when injected before conditioning. The expression o...

journal_title：European journal of pharmacology

authors： Bespalov A,Dumpis M,Piotrovsky L,Zvartau E

更新日期：1994-11-03 00:00:00

abstract：:The role of nitric oxide and cyclo-oxygenase products in the platelet-activating factor (PAF)-induced hyporesponsiveness to noradrenaline was investigated in pithed rats. Infusion of PAF (30 ng/kg/min) for 60 min reduced the mean arterial blood pressure and impaired the pressor responses to noradrenaline (10 ng/kg, 10...

journal_title：European journal of pharmacology

authors： Shiga T,Yoshikawa D

更新日期：1995-08-25 00:00:00

abstract：:The K562 cell line has been proposed as a useful experimental system to identify anti-tumor compounds acting by inducing terminal erythroid differentiation. K562 cells exhibit a low proportion of hemoglobin-synthesizing cells under standard cell growth conditions, but are able to undergo terminal erythroid differentia...

journal_title：European journal of pharmacology

authors： Brognara E,Lampronti I,Breveglieri G,Accetta A,Corradini R,Manicardi A,Borgatti M,Canella A,Multineddu C,Marchelli R,Gambari R

更新日期：2011-12-15 00:00:00

abstract：:[3H]Rauwolscine, a specific and potent alpha 2-antagonist radioligand, was used to characterize alpha 2-receptor binding in bovine cerebral cortex. [3H]Rauwolscine binding was reversible, stereospecific, and saturable. Association, dissociation, and saturation studies revealed one site interactions (k -1/k+1 = 1.2 nM,...

journal_title：European journal of pharmacology

authors： Perry BD,U'Prichard DC

更新日期：1981-12-17 00:00:00