Somatostatin inhibition of VIP-induced somatostatin release, cyclic AMP accumulation and 45Ca2+ uptake in diencephalic cells.

abstract：:Only in the last few years has non-alcoholic steatohepatitis been recognized as an important and relatively common liver disease. To date, the therapeutic options are limited, vitamin E and metformin have been proposed for the treatment of this condition, although their mechanisms are not completely clarified as yet. ...

journal_title：European journal of pharmacology

authors： Raso GM,Esposito E,Iacono A,Pacilio M,Cuzzocrea S,Canani RB,Calignano A,Meli R

更新日期：2009-02-14 00:00:00

abstract：:(5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3 .2.1]octane (PTAC) is a potent muscarinic receptor ligand with high affinity for central muscarinic receptors and no or substantially less affinity for a large number of other receptors or binding sites including dopamine receptors. The ligand exhibits parti...

journal_title：European journal of pharmacology

authors： Bymaster FP,Shannon HE,Rasmussen K,Delapp NW,Mitch CH,Ward JS,Calligaro DO,Ludvigsen TS,Sheardown MJ,Olesen PH,Swedberg MD,Sauerberg P,Fink-Jensen A

更新日期：1998-09-04 00:00:00

abstract：:The physiological role of NPFF/FMRFa family of peptides appears to be complex and exact mechanism of action of these peptides is not yet completely understood. In same line of scrutiny, another analog of YGGFMKKKFMRFamide (YFa), a chimeric peptide of met-enkephalin and FMRFamide, was rationally designed and synthesize...

journal_title：European journal of pharmacology

authors： Vats ID,Chaudhary S,Sharma A,Nath M,Pasha S

更新日期：2010-07-25 00:00:00

abstract：:We employed an ex vivo [(3)H]rolipram binding experiment to elucidate the mechanism of emetic activity of phosphodiesterase 4 inhibitors. In Suncus murinus (an insectivore used for evaluation of emesis), emetic potential as well as ability to occupy the high-affinity rolipram binding site in brain membrane fraction in...

journal_title：European journal of pharmacology

authors： Hirose R,Manabe H,Nonaka H,Yanagawa K,Akuta K,Sato S,Ohshima E,Ichimura M

更新日期：2007-11-14 00:00:00

abstract：:Recent studies suggested the involvement of the endocannabinoid pathway on insulin secretion in RINm5F cells or rat islets. Animal and clinical studies have reported beneficial effects of the selective cannabinoid 1 receptor antagonist rimonabant on glucose homeostasis. The aim of this study was to investigate the in ...

journal_title：European journal of pharmacology

authors： Duvivier VF,Delafoy-Plasse L,Delion V,Lechevalier P,Le Bail JC,Guillot E,Pruniaux MP,Galzin AM

更新日期：2009-08-15 00:00:00

abstract：:Pulmonary and systemic hemodynamic effects of delta 9-tetrahydrocannabinol (delta 9-THC) in conscious dogs and in those anesthetized with morphine (3 mg/kg, i.m.) plus alpha-chloralose (100 mg/kg i.v.) were evaluated in this study. A decrease in the heart rate, cardiac output (PBF) and a concomitant increase in the pu...

journal_title：European journal of pharmacology

authors： Jandhyala BS,Hamed AT

更新日期：1978-12-15 00:00:00

abstract：:Reduced NO levels due to the deficiency of tetrahydrobiopterin (BH(4)) contribute to impaired vasodilation in pulmonary hypertension. Due to the chemically unstable nature of BH(4), it was hypothesised that oxidatively stable analogues of BH(4) would be able to support NO synthesis to improve endothelial dysfunction i...

journal_title：European journal of pharmacology

authors： Kunuthur SP,Milliken PH,Gibson CL,Suckling CJ,Wadsworth RM

更新日期：2011-01-10 00:00:00

abstract：:Three non-steroidal antiinflammatory agents were tested for their ability to antagonize bradykinin in the rabbit jugular vein, the dog carotid artery and the guinea pig trachea. The new agents were compared with indomethacin, as well as with [Thi5,8,D-Phe7] bradykinin and [Thi6,9,D-Phe8] kallidin, two B2 receptor anta...

journal_title：European journal of pharmacology

authors： Rhaleb NE,Dion S,D'Orléans-Juste P,Drapeau G,Regoli D,Browne RG

更新日期：1988-07-07 00:00:00

abstract：:The effect of diazoxide, verapamil and compound D600 on calcium and isoproterenol dose-response relationships was investigated in isolated rabbit atrial preparations. All three agents shifted calcium dose-force relationships parallel and to the right. D600 acted as a competitive antagonist of calcium, as a plot of log...

journal_title：European journal of pharmacology

authors： Bristow MR,Green RD

更新日期：1977-10-01 00:00:00

abstract：:Drugs known to interact with Na+ channels were compared as antagonists of Ca2+-induced contractions of K+-depolarized taenia preparations from guinea-pig caecum. Tetracaine (apparent pA2 5.3 +/- 0.2), quinidine (5.2 +/- 0.1) quinine (5.1 +/- 0.1), d-propranolol (4.7 +/- 0.1), 1-propranolol (4.7 +/- 0.1), lignocaine (4...

journal_title：European journal of pharmacology

authors： Spedding M,Berg C

更新日期：1985-01-22 00:00:00

abstract：:Administration of methyl-beta-carboline-3-carboxamide (FG 7142, 15 mg/kg i.p.) to rats has previously been shown to cause a selective increase in the levels of 3,4-dihydroxy-phenylacetic acid (DOPAC) in the prefrontal cortex and ventral tegmental area (VTA) via an interaction with benzodiazepine receptors. On withdraw...

journal_title：European journal of pharmacology

authors： Ida Y,Roth RH

更新日期：1987-06-04 00:00:00

abstract：:Osteoporosis is a reduction in skeletal mass due to an imbalance between bone resorption and bone formation. Bone morphogenetic protein (BMP) plays important roles in osteoblastic differentiation and bone formation. Therefore, components involved in BMP activation are good targets for the development of anti-osteoporo...

journal_title：European journal of pharmacology

authors： Tang CH,Yang RS,Chien MY,Chen CC,Fu WM

更新日期：2008-01-28 00:00:00

abstract：:Drug addiction shares brain mechanisms and molecular substrates with learning and memory processes, such as the stimulation of glutamate receptors and their downstream signalling pathways. In the present work we provide an up-to-date review of studies that have demonstrated the implication of the main memory-related c...

journal_title：European journal of pharmacology

authors： García-Pardo MP,Roger-Sanchez C,Rodríguez-Arias M,Miñarro J,Aguilar MA

更新日期：2016-06-15 00:00:00

abstract：:Many studies have shown that anti-inflammatory agents are effective in the treatment of endometriosis. β-Caryophyllene exerted a potent anti-inflammatory effect in vivo. However, its effect on endometriosis has not been investigated. This study aims at investigating the effect of β-caryophyllene on endometriosis and o...

journal_title：European journal of pharmacology

authors： Abbas MA,Taha MO,Zihlif MA,Disi AM

更新日期：2013-02-28 00:00:00

abstract：:Angiotensin-converting enzymes, ACE and ACE2, are key members of renin angiotensin system. Activation of ACE2/Ang-(1-7) pathway enhances cardiovascular protective functions of bone marrow-derived stem/progenitor cells. The current study evaluated the selectivity of ACE2 inhibitors, MLN-4760 and DX-600, and ACE and ACE...

journal_title：European journal of pharmacology

authors： Joshi S,Balasubramanian N,Vasam G,Jarajapu YP

更新日期：2016-03-05 00:00:00

abstract：:MPC-1304 is a novel Ca2+ entry blocker of the 1,4-dihydropyridine type. In the present study, the effect of oral administration of MPC-1304 on alpha-adrenoceptor-mediated pressor responses was examined in pithed rats and compared with that of nifedipine. Drugs were administered orally to conscious animals before pithi...

journal_title：European journal of pharmacology

authors： Ichihara K,Okumura K,Mori H,Nagasaka M

更新日期：1993-07-20 00:00:00

abstract：:beta-Funaltrexamine (beta-FNA) bound to mouse brain membranes in a reversible and an irreversible (not removed by washing of the membrane) manner, and a portion of each type of binding was opioid-specific. Addition of 100 mM NaCl to the incubating medium enhanced the binding of beta-FNA to membranes. Using membranes p...

journal_title：European journal of pharmacology

authors： Ward SJ,Fries DS,Larson DL,Portoghese PS,Takemori AE

更新日期：1985-01-08 00:00:00

abstract：:Painless myocardial infarction is a serious complication of diabetes. The present study examined whether cardiac nociception was altered in the streptozotocin-induced diabetic rat model by assessing intrapericardial capsaicin-evoked electromyography (EMG) responses in the spinotrapezius muscle. Somatic sensitivities t...

journal_title：European journal of pharmacology

authors： Liu XH,Qin C,Du JQ,Xu Y,Sun N,Tang JS,Li Q,Foreman RD

更新日期：2011-01-25 00:00:00

abstract：:The effects of caffeine (10 mM) on depolarization-activated, calcium-independent outward K+ currents were investigated in isolated rat ventricular myocytes, using whole-cell clamping. The external solution contained CoCl2 2 mM and the internal solution contained ethylene glycol-bis(-aminoethyl ether) N,N,N',N'-tetraac...

journal_title：European journal of pharmacology

authors： Sanchez-Chapula J

更新日期：1992-12-15 00:00:00

abstract：:Blood pressure responses to intrathecal (i.t.) injection of neurochemicals were examined in the fructose-fed rat, an experimental model of metabolic syndrome.Sprague-Dawley rats receiving either tap water or water containing 10% fructose during 8 weeks were anesthetized with sodium pentobarbital. The endocannabinoid a...

journal_title：European journal of pharmacology

authors： García Mdel C,Godoy YC,Celuch SM

更新日期：2013-04-15 00:00:00

abstract：:The potency and site of action of Ro5-3663 as a GABA antagonist were investigated in the rat cuneate slice in vitro. A Schild plot for Ro5-3663 was clearly non-linear but enabled a pA2 value of 3.97 to be calculated. Combination studies using the 'classical' GABA antagonists bicuculline and picrotoxin indicated that R...

journal_title：European journal of pharmacology

authors： Harrison NL,Simmonds MA

更新日期：1983-01-28 00:00:00

abstract：:Natural purines like ATP, ADP and adenosine have crucial roles in platelet physiology. This knowledge has been significant in drug development and today ADP receptor antagonists are widely used for prevention of thrombotic events following myocardial infarction and ischaemic stroke. Recent studies have shown that a pu...

journal_title：European journal of pharmacology

authors： Kardeby C,Paramel GV,Pournara D,Fotopoulou T,Sirsjö A,Koufaki M,Fransén K,Grenegård M

更新日期：2019-08-15 00:00:00

abstract：:We investigated the effects of methylnaltrexone on morphine-induced inhibition of smooth muscle-strip contraction in isolated guinea-pig ileum and human small intestine. The longitudinal muscle-strip was immersed in a temperature-controlled (37 degrees C) bath containing a physiological solution of 95% O2 and 5% CO2 w...

journal_title：European journal of pharmacology

authors： Yuan CS,Foss JF,Moss J

更新日期：1995-03-24 00:00:00

abstract：:The authors investigated the effects of spinal and supraspinal administration of the benzodiazepine receptor agonist midazolam alone and with opioids on tests of nociception (tail-flick and hot-plate tests) and motor function (catalepsy) in rats. At the spinal level, the dose-response curves for peak effect and area u...

journal_title：European journal of pharmacology

authors： Luger TJ,Hayashi T,Weiss CG,Hill HF

更新日期：1995-03-06 00:00:00

abstract：:Recent studies show that 8-iso-prostaglandin F(2alpha), a member of F(2)-isoprostane family, acts as a vasoconstrictor via TP receptor activation; and its local release may contribute to an abnormal vasomotor tone associated with hypercholesterolemia. The purpose of this study was to examine whether ramatroban, a TP r...

journal_title：European journal of pharmacology

authors： Ishizuka T,Matsui T,Kurita A

更新日期：2003-05-02 00:00:00

abstract：:There has been a flurry of activity to develop agonists and antagonists for the member of the opioid receptor family, NOP receptor (also known as ORL1), in part to understand its role in pain. Modifications of a hexapeptide originally identified from a combinatorial library have led to the discovery of a high affinity...

journal_title：European journal of pharmacology

authors： Khroyan TV,Polgar WE,Orduna J,Zaveri NT,Judd AK,Tuttle DJ,Sanchez A,Toll L

更新日期：2007-03-29 00:00:00

abstract：:The loss of cholinergic neurons and synapses relates to the severity of dementia in several neurodegenerative pathologies; and the vesicular acetylcholine transporter (VAChT) provides a reliable biomarker of cholinergic function. We recently characterized and (11)C-labeled a new VAChT inhibitor, (-)-TZ659. Here we rep...

journal_title：European journal of pharmacology

authors： Liu H,Jin H,Li J,Zhang X,Kaneshige K,Parsons SM,Perlmutter JS,Tu Z

更新日期：2015-04-05 00:00:00

abstract：:Secondary hyperparathyroidism is a common complication in patients with chronic kidney disease and frequently persists after kidney transplantation. Paricalcitol, a selective vitamin D receptor activator, is indicated in the management of this disorder and recent evidences have suggested that this drug has other benef...

journal_title：European journal of pharmacology

authors： Pérez V,Sánchez-Escuredo A,Lauzurica R,Bayés B,Navarro-Muñoz M,Pastor MC,Cañas L,Bonet J,Romero R

更新日期：2013-06-05 00:00:00

abstract：:Minocycline functions as a therapeutic drug in different diseases because of its cytoprotective properties. In the present study, we examined the potential of minocycline to decrease the islet loss in pre-transplantation culture stage. Pancreatic islets were isolated from the deceased donors and treated by 0, 2, 10, a...

journal_title：European journal of pharmacology

authors： Kaviani M,Keshtkar S,Azarpira N,Aghdaei MH,Geramizadeh B,Karimi MH,Shamsaeefar A,Motazedian N,Nikeghbalian S,Al-Abdullah IH

更新日期：2019-09-05 00:00:00

abstract：:Spinal glial activation contributes to the development and maintenance of chronic pain states, including neuropathic pain of diverse etiologies. Cannabinoid compounds have shown antinociceptive properties in a variety of neuropathic pain models and are emerging as a promising class of drugs to treat neuropathic pain. ...

journal_title：European journal of pharmacology

authors： Burgos E,Gómez-Nicola D,Pascual D,Martín MI,Nieto-Sampedro M,Goicoechea C

更新日期：2012-05-05 00:00:00