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Antipyretic activity of cinnamyl derivatives and related compounds in influenza virus-infected mice.

Abstract：

:Kakkon-to is composed of seven medicinal herbs and exhibited novel antipyretic activity by suppressing interleukin-1alpha production responsive to interferon in a murine intranasal influenza virus infection model. Using this model, antipyretic compounds with such novel biological activities were characterized from the herbs. The organic solvent-extractable fractions of Cinnamomum cassia among the herbs showed antipyretic activity. We selected six antipyretic compounds from 48 cinnamyl derivatives and related compounds that may be mainly involved in the fractions. Their antipyretic activity was significantly correlated with interleukin-1alpha regulatory activity. Four of them suppressed interleukin-1alpha production to a basal level and showed different mode of antipyretic action from that of aspirin in interleukin-1alpha-injected mice. Structure-bioactivity relationship of the four suggested that an ester bond played an important role for both antipyretic and interleukin-1alpha regulatory activities. These compounds may be useful in analyzing interleukin-1alpha-producing cells in fever production and the mechanism of defervescence by suppressing interferon-induced interleukin-1alpha production.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Kurokawa M,Kumeda CA,Yamamura J,Kamiyama T,Shiraki K

doi

10.1016/s0014-2999(98)00121-6

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

45-51

issue

1

eissn

0014-2999

issn

1879-0712

pii

S0014299998001216

journal_volume

348

pub_type

杂志文章

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