当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > The role of the mu 2-opioid receptor in the antitussive effect of morphine in mu 1-opioid receptor-deficient CXBK mice.

The role of the mu 2-opioid receptor in the antitussive effect of morphine in mu 1-opioid receptor-deficient CXBK mice.

Abstract：

:The effect of morphine on the capsaicin-induced cough reflex was studied in mu 1-opioid receptor-deficient CXBK mice. There was no significant difference between the morphine-induced antitussive effect in CXBK mice and C57BL/6 mice, a progenitor strain. Furthermore, the antitussive effects of morphine in both the CXBK and C57BL/6 mice were antagonized by pretreatment with either naloxone or beta-funaltrexamine, a mu-opioid receptor antagonist, whereas pretreatment with naltrexonazine, a selective mu 1-opioid receptor antagonist, had no effect. Moreover, naltrindole, a selective delta-receptor antagonist, also had no significant effect on the antitussive effects of morphine in either CXBK or C57BL/6 mice. These results support our previous hypothesis that mu 2- rather than mu 1-opioid receptors are involved in morphine-induced antitussive effects.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Kamei J,Iwamoto Y,Suzuki T,Misawa M,Nagase H,Kasuya Y

doi

10.1016/0014-2999(93)90553-t

subject

Has Abstract

pub_date

1993-08-10 00:00:00

pages

99-101

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(93)90553-T

journal_volume

240

pub_type

杂志文章

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