Abstract:
:In guinea pig papillary muscle, the rate of electrical stimulation (0.1-2 Hz) strongly influenced the effects of the Anemonia sulcata toxin ATX II on action potential duration (APD) and contractile force. In the concentration range studied (10-8-10-7 M), ATX II always produced a larger prolongation in APD at low rates of stimulation. At 0.1 Hz there was a temporal dissociation between the onset of the APD-prolonging and the positive inotropic effect. However, under equilibrium conditions there was a positive relationship between the APD expressed as a fraction of the time during which the membrane was depolarized, and the contractile force irrespective of the change in experimental conditions being variation of stimulation frequency or the addition of ATX II. The results suggest that the positive inotropic effects of both ATX II and increased stimulation frequency could be induced by a similar mechanism, e.g. an increase in sodium of the heart muscle.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Beress L,Ritter R,Ravens Udoi
10.1016/0014-2999(82)90632-xsubject
Has Abstractpub_date
1982-04-23 00:00:00pages
265-72issue
3-4eissn
0014-2999issn
1879-0712pii
0014-2999(82)90632-Xjournal_volume
79pub_type
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