Desensitization of neurokinin A receptors expressed by B82 fibroblasts.

abstract：:Evidence has shown that downstream signaling by mu opioid receptor (MOR) agonists that recruit β-arrestin2 may lead to the development of tolerance. Also, it has been suggested that opioid receptor desensitization and cyclic AMP overshoot contributes to the development of tolerance and occurrence of withdrawal, respec...

journal_title：European journal of pharmacology

authors： Obeng S,Yuan Y,Jali A,Selley DE,Zhang Y

更新日期：2018-05-15 00:00:00

abstract：:Membrane currents in response to the application of alpha, beta-methylene ATP (alpha,beta-meATP) were recorded by the whole-cell patch-clamp technique in human embryonic kidney 293 cells transfected with the human P2X3 receptor (HEK 293-hP2X3 cells). Trichloroethanol, the biologically active metabolite of chloral hydr...

journal_title：European journal of pharmacology

authors： Köles L,Wirkner K,Fürst S,Wnendt S,Illes P

更新日期：2000-12-15 00:00:00

abstract：:Malfunction of the serotonergic system and dysregulation of the hypothalamo-pituitary-adrenocortical axis have been implicated in the pathophysiology of depression. Several studies provide evidence for reciprocal influences between glucocorticoids and 5-HT receptors. The effect of repeated treatment with a high dose o...

journal_title：European journal of pharmacology

authors： Berendsen HH,Kester RC,Peeters BW,Broekkamp CL

更新日期：1996-07-18 00:00:00

abstract：:Clinical and experimental data indicate that the cerebral cortex plays an important role in pain perception and endogenous antinociceptive system function. Moreover, the enhancement of descending inhibitory cortical control may be involved in the mechanisms of analgetic effect of some agents. The present study was des...

journal_title：European journal of pharmacology

authors： Kharkevich DA,Churukanov VV

更新日期：1999-06-30 00:00:00

abstract：:Ulcerative colitis (UC), as an autoimmune disease, has been troubling human health for many years. Up to now, the available treatments remain unsatisfactory. Rhizoma Coptidis has been widely applied to treat gastrointestinal diseases in China for a long time, and coptisine (COP) is identified as one of its major activ...

journal_title：European journal of pharmacology

authors： Wang Y,Liu J,Huang Z,Li Y,Liang Y,Luo C,Ni C,Xie J,Su Z,Chen J,Li C

更新日期：2021-01-25 00:00:00

abstract：:Ellagic acid, a natural phenol compound found in numerous fruits and vegetables, causes various physiological effects in different cell models. However, the effect of this compound on Ca(2+) homeostasis in liver cells is unknown. This study examined the effect of ellagic acid on intracellular Ca(2+) concentration ([Ca...

journal_title：European journal of pharmacology

authors： Liang WZ,Chou CT,Cheng JS,Wang JL,Chang HT,Chen IS,Lu T,Yeh JH,Kuo DH,Shieh P,Chen FA,Kuo CC,Jan CR

更新日期：2016-06-05 00:00:00

abstract：:The present study investigated the effect of acidosis (reduction in pH of the Krebs' solution from 7.4 to 6.9) on responses to vasoconstrictors and vasodilators, with a focus on purines, in the rat isolated perfused mesenteric arterial bed. alpha,beta-Methylene ATP (alpha,beta-meATP) (10 microM), a selective P2X recep...

journal_title：European journal of pharmacology

authors： Ralevic V

更新日期：2000-10-06 00:00:00

abstract：:Prulifloxacin, a new thiazeto-quinoline derivative with antibiotic properties, was evaluated for cardiac risk both in vitro on the ether-à-go-go-related gene (HERG) K+ channel, and in vivo in the conscious dog monitored by telemetry. HERG current was measured from stably transfected human embryonic kidney (HEK) 293 ce...

journal_title：European journal of pharmacology

authors： Lacroix P,Crumb WJ,Durando L,Ciottoli GB

更新日期：2003-09-05 00:00:00

abstract：:Spinal glial activation contributes to the development and maintenance of chronic pain states, including neuropathic pain of diverse etiologies. Cannabinoid compounds have shown antinociceptive properties in a variety of neuropathic pain models and are emerging as a promising class of drugs to treat neuropathic pain. ...

journal_title：European journal of pharmacology

authors： Burgos E,Gómez-Nicola D,Pascual D,Martín MI,Nieto-Sampedro M,Goicoechea C

更新日期：2012-05-05 00:00:00

abstract：:The mesolimbic dopaminergic innervation is supposed to be involved in the mechanisms of central effects exerted by various classes of psychotropic drugs. Antidepressants have been found to interact with the brain dopaminergic system as well, although the precise central location of this interaction is unknown. Some da...

journal_title：European journal of pharmacology

authors： Plaznik A,Kostowski W

更新日期：1987-03-31 00:00:00

abstract：:The purpose of this study was to delineate the distribution of beta-adrenoceptor density in the cat heart, with an emphasis on areas within the left ventricle. beta-Adrenoceptor densities, determined for hearts obtained from five cats, were not significantly different in the left and rights atria, i.e. 47.6 +/- 7.2 an...

journal_title：European journal of pharmacology

authors： Lathers CM,Levin RM,Spivey WH

更新日期：1986-10-14 00:00:00

abstract：:Induction of inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production is thought to have beneficial immunomodulatory effects in acute and chronic inflammatory disorders. In Raw 264.7 cells stimulated with lipopolysaccharide (LPS) to mimic inflammation, withaferin A inhibited LPS-induced expre...

journal_title：European journal of pharmacology

authors： Oh JH,Lee TJ,Park JW,Kwon TK

更新日期：2008-12-03 00:00:00

abstract：:This study investigated the involvement of the opioid system in the antidepressant-like effect of adenosine in the forced swimming test. The effect of adenosine (10 mg/kg, i.p.) was prevented by the pretreatment of mice with naloxone (1 mg/kg, i.p., a nonselective opioid receptor antagonist), naltrindole (3 mg/kg, i.p...

journal_title：European journal of pharmacology

authors： Kaster MP,Budni J,Santos AR,Rodrigues AL

更新日期：2007-12-08 00:00:00

abstract：:The influence of native low-density lipoprotein (LDL) on the inhibition of endothelium-dependent relaxation previously induced by oxidized LDL was investigated with intact rabbit aortic rings. We also tried to assess oxysterol involvement in the native lipoprotein effects. Lipoprotein fractions (1 mg protein/ml) were ...

journal_title：European journal of pharmacology

authors： Perségol L,Sementa V,Athias A,Lecerf J,Lallemant C,Gambert P

更新日期：2000-10-20 00:00:00

abstract：:The ability of the prostacyclin (IP) receptor agonist cicaprost to activate Gs-, Gq/11- and Gi-mediated cell signalling pathways has been examined in Chinese hamster ovary (CHO) cells and human embryonic kidney 293 (HEK 293) cells expressing the cloned human (hIP) or mouse (mIP) prostacyclin receptor, and compared wit...

journal_title：European journal of pharmacology

authors： Chow KB,Jones RL,Wise H

更新日期：2003-08-01 00:00:00

abstract：:Using isolated rabbit gastric glands, the H2-receptor antagonist MK-208 was investigated with respect to its effects on [14C]aminopyrine uptake as an index of gastric acid secretion. In addition to shifting the histamine concentration-response curve to the right in a parallel fashion, the antagonism produced by MK-208...

journal_title：European journal of pharmacology

authors： Shepherd-Rose AJ,Pendleton RG

更新日期：1984-11-13 00:00:00

abstract：:Captivity-induced stereotypies in bank voles (Clethrionomys glareolus) were inhibited at the age of 1, 2, 4, 6, 8 and 10 months by 0.2 mg/kg haloperidol s.c., while 35 mg/kg naloxone s.c. only inhibited them at the age of 4-6 months. Other activities were not significantly inhibited. The change in the naloxone effect ...

journal_title：European journal of pharmacology

authors： Kennes D,Odberg FO,Bouquet Y,De Rycke PH

更新日期：1988-08-09 00:00:00

abstract：:Inhibition of interleukin-6 (IL-6) holds significant promise as a therapeutic approach for triple negative breast cancer (TNBC). We previously reported that phenylmethimazole (C10) reduces IL-6 expression in several cancer cell lines. We have identified a more potent derivative of C10 termed COB-141. In the present wo...

journal_title：European journal of pharmacology

authors： Noori MS,O'Brien JD,Champa ZJ,Deosarkar SP,Lanier OL,Qi C,Burdick MM,Schwartz FL,Bergmeier SC,McCall KD,Goetz DJ

更新日期：2017-05-15 00:00:00

abstract：:In this study, the elevated zero-maze model of anxiety was used to investigate CCK receptor antagonist effects on the behaviour of male Lister-hooded rats and to demonstrate, by administering antagonists in the presence or absence of selective 5-hydroxytryptamine (5-HT) re-uptake inhibitors, the involvement of 5-HT in...

journal_title：European journal of pharmacology

authors： Bickerdike MJ,Marsden CA,Dourish CT,Fletcher A

更新日期：1994-12-27 00:00:00

abstract：:Pressor and bradycardiac responses induced by electrical stimulation of the mesencephalic reticular formation in urethane-anesthetized rats were used as model of neurogenic hypertension. Oxytocin (OXT) and prolyl-leucyl-glycinamide (OXT-(7-9] administered into the fourth cerebral ventricle markedly attenuated the magn...

journal_title：European journal of pharmacology

authors： Versteeg CA,Cransberg K,De Jong W,Bohus B

更新日期：1983-10-14 00:00:00

abstract：:Detailed antagonist competition curves for [3H]prazosin-labelled binding sites in rat cerebral cortex membranes reveal anomalous binding characteristics. Dihydroergocryptine and indoramine compete in a steep, monophasic manner while WB4101 and phentolamine exhibit shallow competition curves. Computer-assisted analysis...

journal_title：European journal of pharmacology

authors： Morrow AL,Battaglia G,Norman AB,Creese I

更新日期：1985-02-26 00:00:00

abstract：:[3H]Indapamide bound to a single class of binding sites in pig renal cortex membranes with a dissociation constant Kd = 35 +/- 13 nM and a binding site density Bmax = 40 +/- 9 pmol/mg of protein. [3H]Indapamide binding was inhibited by the carbonic anhydrase inhibitor, acetazolamide, and by thiazide diuretics with the...

journal_title：European journal of pharmacology

authors： Schaeffer P,Vigne P,Frelin C,Lazdunski M

更新日期：1990-07-17 00:00:00

abstract：:Depression and cocaine use disorder represent frequent co-current diagnoses and the GABAB receptors are involved in both conditions. This research involved the application of the animal model of depression (bulbectomy, OBX) and cocaine use disorder (self-administration) to assess the efficiency of GABAB receptor agoni...

journal_title：European journal of pharmacology

authors： Gawlińska K,Jastrzębska J,Gamberini S,Gawliński D,Pieniążek R,Suder A,Wydra K,Frankowska M

更新日期：2020-09-15 00:00:00

abstract：:The aims were to test whether 2 weeks treatment with the beta2-adrenoceptor agonist, salbutamol, or the alpha1-adrenoceptor antagonist, doxazosin, could correct nerve blood flow and conduction velocity deficits in 8 week streptozotocin-diabetic rats and to examine neurovascular mechanisms using co-treatment with the n...

journal_title：European journal of pharmacology

authors： Cotter MA,Cameron NE

更新日期：1998-02-19 00:00:00

abstract：:Alterations in iron homeostasis are well described in obese patients. The effects of iron chelators on adipose tissue and other organs affected by obesity have been the interest of experimental studies, both in vivo and in vitro. The aim of this review was to update the available information indicating the potential o...

journal_title：European journal of pharmacology

authors： Rodrigues de Morais T,Gambero A

更新日期：2019-10-15 00:00:00

abstract：:Lithium, commonly used to treat bipolar disorder, potentiates the ability of the muscarinic agonist pilocarpine to induce seizures in rodents. As this potentiation by lithium is reversed by the administration of myo-inositol, the potentiation may be mediated by inhibition of inositol monophosphatase (IMPase), a known ...

journal_title：European journal of pharmacology

authors： Singh N,Serres F,Toker L,Sade Y,Blackburn V,Batra AS,Saiardi A,Agam G,Belmaker RH,Sharp T,Vasudevan SR,Churchill GC

更新日期：2020-09-15 00:00:00

abstract：:The effects of a serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) on serum leptin levels were investigated in mice. 5-HTP dose dependently increased serum leptin levels in mice. Pretreatment of the peripheral aromatic amino acid decarboxylase inhibitor carbidopa suppressed 5-HTP-induced hyperleptinemia. These re...

journal_title：European journal of pharmacology

authors： Yamada J,Sugimoto Y,Ujikawa M

更新日期：1999-10-21 00:00:00

abstract：:Toll-like receptors (TLRs) play an important role in the recognition of microbial pathogens and induce innate immune responses. The recognition of microbial components by TLRs triggers the activation of myeloid differential factor 88 (MyD88)- and toll-interleukin-1 receptor domain-containing adapter inducing interfero...

journal_title：European journal of pharmacology

authors： Gu GJ,Eom SH,Suh CW,Koh KO,Kim DY,Youn HS

更新日期：2013-12-05 00:00:00

abstract：:The antinociceptive profile of selected histamine H(2) and histamine H(3) receptor antagonists led to the discovery of improgan, a non-brain-penetrating analgesic agent which does not act on known histamine receptors. Because no chemical congener of improgan has yet been discovered which has both antinociceptive and b...

journal_title：European journal of pharmacology

authors： Hough LB,Nalwalk JW,Lu Q,Shan Z,Svokos K,Wentland MP,Montero MJ

更新日期：2005-10-17 00:00:00

abstract：:Dopamine (DA) is thought to have a neurotransmitter role in the spinal cord of the rat. Intrathecal administration of the DA receptor agonist apomorphine has previously been shown to reduce nocifensive responses. The present experiments investigated the site of action of apomorphine, and the mechanisms by which DA ago...

journal_title：European journal of pharmacology

authors： Barasi S,Duggal KN

更新日期：1985-11-19 00:00:00