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Changes in naloxone and haloperidol effects during the development of captivity-induced jumping stereotypy in bank voles.

Abstract：

:Captivity-induced stereotypies in bank voles (Clethrionomys glareolus) were inhibited at the age of 1, 2, 4, 6, 8 and 10 months by 0.2 mg/kg haloperidol s.c., while 35 mg/kg naloxone s.c. only inhibited them at the age of 4-6 months. Other activities were not significantly inhibited. The change in the naloxone effect was not due to desensitization as animals treated only at 6 or 8 months reacted similarly. It is suggested that the expression of such stereotypies is influenced by endogeneous brain opioid peptides during an early stage of their development, but that thereafter only motoric automatisms remain, essentially under dopaminergic control.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Kennes D,Odberg FO,Bouquet Y,De Rycke PH

doi

10.1016/0014-2999(88)90583-3

subject

Has Abstract

pub_date

1988-08-09 00:00:00

pages

19-24

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(88)90583-3

journal_volume

153

pub_type

杂志文章

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