Abstract:
:Previous functional studies with the rat jugular vein have shown alpha-adrenergically mediated contraction was minimal to nonexistent, yet this tissue relaxed in response to norepinephrine via beta 1 and to isoproterenol via beta 2-receptor activation. Unlike the rat jugular vein, the rat aorta markedly contracted to norepinephrine and relaxed to beta-adrenoceptor stimulation. This study qualitatively examined the alpha- and beta-receptor distributions in the rat jugular vein, as compared to the rat aorta, with autoradiographical methods. Cross-sections of blood vessels were labelled with the alpha-receptor ligand, [125I]HEAT ([beta-(4-hydroxy-3-iodophenyl)-ethyl-aminomethyl]-tetralone) and the beta-receptor ligand, [125I]ICYP (iodo-cyanopindolol), and subsequently were opposed to emulsion coated coverslips. Specific binding of both alpha- and beta-receptors was demonstrated in the rat aorta. While specific beta-receptor binding was demonstrated in the rat jugular vein, this tissue showed no detectable alpha-receptors. These autoradiographic studies indicate that the lack of alpha-adrenergically mediated contraction in the rat jugular vein is likely due to a virtual absence of alpha-receptor binding sites, rather than poor functional alpha-receptor coupling.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Killam AL,Cohen MLdoi
10.1016/0014-2999(92)90182-4keywords:
subject
Has Abstractpub_date
1992-08-06 00:00:00pages
295-301issue
2-3eissn
0014-2999issn
1879-0712pii
0014-2999(92)90182-4journal_volume
218pub_type
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