Muscarinic receptor agonists decrease cocaine self-administration rates in drug-naive mice.

abstract：:The role of substance P in the cerebral parenchymal circulation was examined in 19 anesthetized cats. The local cerebral blood volume in the temporoparietal cortex was measured by our photoelectric method. Cerebral blood volume reflects the cumulative dimensions of the parenchymal microvessels. Intravenous injection o...

journal_title：European journal of pharmacology

authors： Kobari M,Tomita M,Tanahashi N,Yokoyama M,Takao M,Fukuuchi Y

更新日期：1996-12-19 00:00:00

abstract：:The endogenous cannabinoid system has been noted for its therapeutic potential, as well as the psychoactivity of cannabinoids such as Δ9-tetrahydrocannabinol (THC). However, less is known about the psychoactivity of anandamide (AEA), an endocannabinoid ligand. Thus, the goals of this study were to establish AEA as a d...

journal_title：European journal of pharmacology

authors： Walentiny DM,Gamage TF,Warner JA,Nguyen TK,Grainger DB,Wiley JL,Vann RE

更新日期：2011-04-10 00:00:00

abstract：:The aim of the study was to investigate whether diabetes mellitus modulated the function and expression of P-glycoprotein and the distribution of phenobarbital in the brain of 3-week streptozotocin-induced diabetic mice. P-glycoprotein function in blood-brain barrier was assessed by measuring the brain-to-plasma conce...

journal_title：European journal of pharmacology

authors： Liu H,Zhang D,Xu X,Liu X,Wang G,Xie L,Pang X,Liu L

更新日期：2007-04-30 00:00:00

abstract：:A neonatal cerebral cortical lesion was made in rats and the effects of diazepam on ultrasonic isolation calls in pups and footshock-elicited ultrasonic distress calls in young adult rats were assessed. There was no indication that the cortical lesion influenced the production of the ultrasonic distress calls in eithe...

journal_title：European journal of pharmacology

authors： Naito H,Arishima K,Tonoue T

更新日期：1995-01-16 00:00:00

abstract：:Recent studies show that 8-iso-prostaglandin F(2alpha), a member of F(2)-isoprostane family, acts as a vasoconstrictor via TP receptor activation; and its local release may contribute to an abnormal vasomotor tone associated with hypercholesterolemia. The purpose of this study was to examine whether ramatroban, a TP r...

journal_title：European journal of pharmacology

authors： Ishizuka T,Matsui T,Kurita A

更新日期：2003-05-02 00:00:00

abstract：:Activation of imidazoline receptors in the central nervous system has protective effect on several types of arrhythmias. We demonstrated that centrally administered rilmenidine, a selective imidazoline receptor agonist, prevented adrenaline-induced arrhythmias during halothane anaesthesia. However, detailed myocardial...

journal_title：European journal of pharmacology

authors： Yamanaka H,Hayashi Y,Iwasaki M,Kamibayashi T,Yamatodani A,Mashimo T

更新日期：2010-11-25 00:00:00

abstract：:The effect of dynorphin A-(1-13) on morphine-induced urine output was studied in the rat. The previous simultaneous intracerebroventricular (i.c.v.) injection of dynorphin (20 micrograms/rat) and morphine (20 micrograms/rat) altered the response of rat given morphine (20 micrograms/rat) 24 h later, producing a 3-fold ...

journal_title：European journal of pharmacology

authors： Hong O,Young GA,Khazan N

更新日期：1986-12-02 00:00:00

abstract：:The effects of a highly selective kappa antagonist, nor-binaltorphimine (nor-BNI), on the development of tolerance to morphine analgesia and physical dependence on morphine were examined. Pretreatment with nor-BNI (5 mg/kg s.c.) 2 h prior to injection of morphine or a selective kappa agonist, U-50,488H, significantly ...

journal_title：European journal of pharmacology

authors： Suzuki T,Narita M,Takahashi Y,Misawa M,Nagase H

更新日期：1992-03-17 00:00:00

abstract：:Striatal neurons in primary culture express a wide variety of adenylate cyclase-coupled receptors, and particularly dopamine (DA) D1 receptors, which are known to induce an increase in cyclic AMP production. To study desensitization of those receptor-mediated responses, neurons were incubated in the presence of satura...

journal_title：European journal of pharmacology

authors： Chneiweiss H,Glowinski J,Premont J

更新日期：1990-10-30 00:00:00

abstract：:Guanosine 3',5'-cyclic monophosphate (cGMP) is an important second messenger in many biological systems including vascular smooth muscle where it mediates relaxation. Cellular levels of cGMP are regulated primarily by three enzymes; nitric oxide (NO) synthase, soluble guanylate cyclase, and cGMP-phosphodiesterase. Bas...

journal_title：European journal of pharmacology

authors： Bina S,Hart JL,Sei Y,Muldoon SM

更新日期：1998-06-19 00:00:00

abstract：:Although cannabinoids are known to be more effective analgesics against chronic rather than acute pain, the mechanism underlying this phenomenon is still unclear. We report now that contralateral thalamic cannabinoid CB(1) receptors are upregulated after unilateral axotomy of the tibial branch of the sciatic nerve, a ...

journal_title：European journal of pharmacology

authors： Siegling A,Hofmann HA,Denzer D,Mauler F,De Vry J

更新日期：2001-03-09 00:00:00

abstract：:Kisspeptin (KP), the endogenous ligand of GPR54, is a mammalian amidated neurohormone, which belongs to the RF-amide peptide family. However, in contrast with the related members of the RF-amide family, little information is available regarding its role in the gastrointestinal motility. With regard to the recent data ...

journal_title：European journal of pharmacology

authors： Jiang J,Jin W,Peng Y,He Z,Wei L,Li S,Wang X,Chang M,Wang R

更新日期：2017-01-05 00:00:00

abstract：:The angiotensin II-induced vasodilatation was evaluated in rat middle cerebral artery, especially regarding endothelium-derived hyperpolarising factor (EDHF), by use of a pressurised arteriograph. The angiotensin II dilatation was partly antagonised by inhibitors of nitric oxide synthase and cyclo-oxygenase. The remai...

journal_title：European journal of pharmacology

authors： Wackenfors A,Vikman P,Nilsson E,Edvinsson L,Malmsjö M

更新日期：2006-02-15 00:00:00

abstract：:The effects of the long-term administration of diazepam on the potential difference and short-circuit current of the isolated skin of the toad Pleurodema thaul (P. thaul) were investigated. Diazepam applied in a concentration range of 4.6 x 10(-6) to 5.2 x 10(-5) M decreased both electrical parameters. This response w...

journal_title：European journal of pharmacology

authors： Norris B,Contreras E,Nunez G,Contreras G

更新日期：1995-07-04 00:00:00

abstract：:Na+-H+ exchange inhibitors may reduce myocardial damage after reperfusion. However, their effects on microvascular deterioration are not known. We examined the potency of a novel Na+-H+ exchange inhibitor, SM-20550 [ N-(Aminoiminomethyl)-1,4-dimethyl-1H-indole-2-carboxamide methanesulfonate], and its effects on microv...

journal_title：European journal of pharmacology

authors： Ito Y,Imai S,Ui G,Nakano M,Imai K,Kamiyama H,Naganuma F,Matsui K,Ohashi N,Nagai R

更新日期：1999-06-25 00:00:00

abstract：:The effect of vasoactive intestinal polypeptide (VIP) on in vitro ACTH release and adenylate cyclase activity was investigated in human ACTH-secreting pituitary adenomas from 4 patients with Cushing's disease and 2 patients with Nelson's syndrome. In all the tumors tested, VIP elicited a dose-dependent stimulation of ...

journal_title：European journal of pharmacology

authors： Oliva D,Nicosia S,Spada A,Giannattasio G

更新日期：1982-09-10 00:00:00

abstract：:Agelanthus dodoneifolius is one of the medicinal plants used in African pharmacopeia and traditional medicine for the treatment of cardiovascular diseases. A chemical analysis has identified one of the active principles: Dodoneine (Ddn). It is a new dihydropyranone which exerts hypotensive and vasorelaxant effects on ...

journal_title：European journal of pharmacology

authors： Carré G,Carreyre H,Ouedraogo M,Becq F,Bois P,Thibaudeau S,Vandebrouck C,Bescond J

更新日期：2014-04-05 00:00:00

abstract：:Glomeruli isolated from rat kidney cortex were incubated with adenosine in the presence or absence of verapamil and calcium and their change in cross-sectional area was recorded. Adenosine induced a 10% decrease in glomerular cross-sectional area. This decrease was blocked by verapamil or a calcium-free medium. The re...

journal_title：European journal of pharmacology

authors： López-Novoa JM,de Arriba G,Barrio V,Rodriguez-Puyol D

更新日期：1987-02-24 00:00:00

abstract：:We have examined the effects of intrathecally (i.t.) administered CP-96,345, a non-peptide NK1 receptor ligand, on the spinal nociceptive flexor reflex and on the facilitation of this reflex evoked by i.t. substance P (SP), neurokinin A (NKA) and electrical conditioning stimulation of cutaneous C-afferents. CP-96,345 ...

journal_title：European journal of pharmacology

authors： Xu XJ,Dalsgaard CJ,Wiesenfeld-Hallin Z

更新日期：1992-06-17 00:00:00

abstract：:Docetaxel is a first line chemotherapy agent, which stabilizes microtubules in metastatic prostate cancer (PCa). Resistance to Docetaxel and its side effects remain as obstacle for its efficacy in monotherapy. Recently, combination with novel adjuvants have been emerged as a beneficial alternative strategy, which targ...

journal_title：European journal of pharmacology

authors： Eftekhari S,Montazeri H,Tarighi P

更新日期：2020-07-05 00:00:00

abstract：:Indomethacin and ibuprofen inhibited adrenaline- and calcium ionophore A23187-stimulated 45Ca2+ uptake by isolated human platelets in a concentration-dependent manner. Mediation of these effects by thromboxane A2 (TXA2) inhibition was discounted since under the same experimental conditions, adrenaline did not stimulat...

journal_title：European journal of pharmacology

authors： Gill J,Dandona P,Jeremy JY

更新日期：1990-10-02 00:00:00

abstract：:Corticotropin-releasing factor (CRF) has been suggested to play an important role in the development of drug dependence and withdrawal. Based on the recent finding that CRF receptor antagonists inhibit the stress-induced relapse to opiate dependence and attenuate anxiety-like responses related to cocaine withdrawal, t...

journal_title：European journal of pharmacology

authors： Lu L,Liu D,Ceng X

更新日期：2001-03-01 00:00:00

abstract：:Piceatannol (3,3',4,5'-tetrahydroxy-trans-stilbene) is a polyphenol present in grapes and wine. By means of alkaline phosphatase activity and osteocalcin enzyme-linked immunosorbent assay (ELISA), we have shown that piceatannol exhibits a significant induction of differentiation in immortalized fetal osteoblasts (hFOB...

journal_title：European journal of pharmacology

authors： Chang JK,Hsu YL,Teng IC,Kuo PL

更新日期：2006-12-03 00:00:00

abstract：:There is now evidence from human studies to suggest that cardiac beta-adrenoceptor density and coupling to adenylate cyclase may be regulated in a subtype selective fashion. An animal model was used to investigate this further. Rats were infused for 6 days with the non-selective full agonist isoprenaline (n = 6) or th...

journal_title：European journal of pharmacology

authors： Arnold IR,Mistry R,Barnett DB

更新日期：1993-05-15 00:00:00

abstract：:Previous studies show that naringenin promotes insulin sensitivity in fructose-fed rats. This study investigates whether naringenin prevents oxidative events and apoptotic changes triggered in the rat liver by a high fructose diet. Male Wistar rats of body weight 150-180 g were fed either diet containing starch (60% c...

journal_title：European journal of pharmacology

authors： Kannappan S,Palanisamy N,Anuradha CV

更新日期：2010-10-25 00:00:00

abstract：:Vagal motor outflow from the dorsal vagal complex is important in the regulation of intestinal motility. The aim of our study was to test the hypothesis that within the dorsal vagal complex, tonic GABA(A)-receptor mediated neurotransmission modulates intestinal motility. The GABA(A) receptor antagonist, bicuculline (m...

journal_title：European journal of pharmacology

authors： Greenwood-Van Meerveld B,Barron KW

更新日期：1998-04-10 00:00:00

abstract：:The increases in activity of hepatic thymidylate synthetase and of thymidine kinase, which catalyze the formation of thymidylate via the de novo and salvage pathways, respectively, were significantly suppressed during liver regeneration in rats which had been given alpha-adrenoceptor antagonists (phenoxybenzamine and ...

journal_title：European journal of pharmacology

authors： Nakata R,Tsukamoto I,Nanme M,Makino S,Miyoshi M,Kojo S

更新日期：1985-08-27 00:00:00

abstract：:The activation of adenosine A(2B) receptors in human mast cells causes pro-inflammatory responses such as the secretion of interleukin-8. There is evidence for an inhibitory effect of benzodiazepines on mast cell mediated symptoms in patients with systemic mast cell activation disease. Therefore, we investigated the e...

journal_title：European journal of pharmacology

authors： Hoffmann K,Xifró RA,Hartweg JL,Spitzlei P,Meis K,Molderings GJ,von Kügelgen I

更新日期：2013-01-30 00:00:00

abstract：:A previous report showed that transforming growth factor-beta1 (TGF-beta1) can induce heme oxygenase-1 (HO-1) expression, attenuate cellular injury, and maintain tissue homeostasis. In this study, we investigated the involvement of phosphoinositide-3-OH-kinase (PI3K)/Akt and the nuclear factor-kappaB (NF-kappaB) signa...

journal_title：European journal of pharmacology

authors： Lin CC,Chiang LL,Lin CH,Shih CH,Liao YT,Hsu MJ,Chen BC

更新日期：2007-04-10 00:00:00

abstract：:The ability of the novel non-glucocorticoid 21-aminosteroid U74006F to protect against the development of hemorrhagic shock was examined in pentobarbital-anesthetized cats. The animals were hemorrhaged to a mean arterial blood pressure (MAP) of 45-50 mm Hg where they were held for 2 h. At the end of the hemorrhage per...

journal_title：European journal of pharmacology

authors： Hall ED,Yonkers PA,McCall JM

更新日期：1988-03-01 00:00:00