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Intracerebroventricular morphine produces diuresis 24 h after previous dynorphin/morphine treatment.

Abstract：

:The effect of dynorphin A-(1-13) on morphine-induced urine output was studied in the rat. The previous simultaneous intracerebroventricular (i.c.v.) injection of dynorphin (20 micrograms/rat) and morphine (20 micrograms/rat) altered the response of rat given morphine (20 micrograms/rat) 24 h later, producing a 3-fold increase in urine output. In contrast, previous injection of dynorphin or morphine alone had no effect.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Hong O,Young GA,Khazan N

doi

10.1016/0014-2999(86)90015-4

subject

Has Abstract

pub_date

1986-12-02 00:00:00

pages

83-5

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(86)90015-4

journal_volume

132

pub_type

杂志文章

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